Results 11 to 20 of about 28,237 (223)
Pseudomonas aeruginosaAmpR: an acute-chronic switch regulator [PDF]
Pathogens and Disease, 2014 Pseudomonas aeruginosa is one of the most intractable human pathogens that pose serious clinical challenge due to extensive prevalence of multidrug-resistant clinical isolates. Armed with abundant virulence and antibiotic resistance mechanisms, it is a major etiologic agent in a number of acute and chronic infections. A complex and intricate network of
Deepak Balasubramanian +2 more
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Identification of Bacterial Membrane Selectivity of Romo1-Derived Antimicrobial Peptide AMPR-22 via Molecular Dynamics [PDF]
International Journal of Molecular Sciences, 2022 The abuse or misuse of antibiotics has caused the emergence of extensively drug-resistant (XDR) bacteria, rendering most antibiotics ineffective and increasing the mortality rate of patients with bacteremia or sepsis. Antimicrobial peptides (AMPs) are proposed to overcome this problem; however, many AMPs have attenuated antimicrobial activities with ...
Hana Kim, Young Do Yoo, Gi Young Lee
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Structural and Functional Characterization of Pseudomonas aeruginosa Global Regulator AmpR [PDF]
Journal of Bacteriology, 2014 ABSTRACTPseudomonas aeruginosais a dreaded pathogen in many clinical settings. Its inherent and acquired antibiotic resistance thwarts therapy. In particular, derepression of the AmpC β-lactamase is a common mechanism of β-lactam resistance among clinical isolates.
Olivier Caille +10 more
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Nucleotide sequence of the ampC-ampR region from the chromosome of Yersinia enterocolitica [PDF]
Antimicrobial Agents and Chemotherapy, 1992 The nucleotide sequence of a 3.1-kb region from the chromosome of the Yersinia enterocolitica O:5b strain IP97 containing the gene for an inducible chromosomal cephalosporinase has been determined. The cephalosporinase gene was homologous to other enterobacterial chromosomal cephalosporinase genes, and it was accompanied by a gene homologous to the ...
Asunción Seoane +2 more
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Infection and Drug Resistance, 2020 Min Zhang,1,* Jinyong Zhang,2,* Jia Li,3 Xianglin Wu,4 Lihua Xiao,4 Xueyan Liu,5 Xiyao Yang,6 Liqi Yang,7 Quanming Zou,2 Wei Huang1 1Bacteriology & Antibacterial Resistance Surveillance Laboratory, Shenzhen Institute of Respiratory Diseases, Shenzhen
M Zhang +9 more
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Pseudomonas Aeruginosa AmpR Transcriptional Regulatory Network
, 2013 Deepak Balasubramanian
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ACS Chemical Biology, 2020 Gram-negative bacteria have evolved an elaborate pathway to sense and respond to exposure to β-lactam antibiotics. The β-lactam antibiotics inhibit penicillin-binding proteins, whereby the loss of their activities alters/damages the cell-wall peptidoglycan. Bacteria sense this damage and remove the affected peptidoglycan into complex recycling pathways.
David A. Dik +5 more
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Genome Sequence of Stenotrophomonas maltophilia S028, an Isolate Harboring the AmpR-L2 Resistance Module [PDF]
Journal of Bacteriology, 2012 ABSTRACT Multidrug-resistant Stenotrophomonas maltophilia has emerged as an important cause of nosocomial infections, which is attributable mainly to the production of diverse β-lactamases by S. maltophilia .
Shiping Song +9 more
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Overproduction, solubilization, purification and DNA‐binding properties of AmpR from Citrobacter freundii [PDF]
European Journal of Biochemistry, 1993 AmpR belongs to the LysR family of prokaryotic DNA‐binding transcriptional regulators and controls induction of the enterobacterial ampCβ‐lactamase gene. The ampR gene of Citrobacter freundii was deregulated by employing the polymerase chain reaction to introduce an efficient ribosome‐binding sequence and suitable restriction enzyme sites for cloning ...
Russell E. Bishop, Joël H. Weiner
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Deep sequencing analyses expands the Pseudomonas aeruginosa AmpR regulon to include small RNA-mediated regulation of iron acquisition, heat shock and oxidative stress response [PDF]
, 2013 Pathogenicity of Pseudomonas aeruginosa, a major cause of many acute and chronic human infections, is determined by tightly regulated expression of multiple virulence factors.
Deepak Balasubramanian +8 more
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