Results 31 to 40 of about 28,237 (223)

<p>AmpR Increases the Virulence of Carbapenem-Resistant <em>Klebsiella pneumoniae</em> by Regulating the Initial Step of Capsule Synthesis</p>

open access: goldInfection and drug resistance, 2020
Non-hypermucoviscous carbapenem-resistant Klebsiella pneumoniae with enhanced virulence lacking hvKP-specific virulence factors is uncommon, and the virulence mechanisms of this organism are not understood.Following a retrospective study of carbapenem-resistant K. pneumoniae based on core genome multilocus sequence typing (cgMLST), isolates that caused
Min Zhang   +9 more
openalex   +6 more sources

An Efficient, Counter-Selection-Based Method for Prophage Curing in Pseudomonas aeruginosa Strains

open access: yesViruses, 2021
Prophages are bacteriophages in the lysogenic state, where the viral genome is inserted within the bacterial chromosome. They contribute to strain genetic variability and can influence bacterial phenotypes. Prophages are highly abundant among the strains
Esther Shmidov   +5 more
doaj   +1 more source

Molecular mechanisms of ceftazidime resistance in Pseudomonas aeruginosa isolates from canine and human infections

open access: yesVeterinární Medicína, 2010
Sixty-six clinical P. aeruginosa isolates, 17 obtained from canine otitis specimens and 49 received from human patients with bloodstream infections, were collected between February 2007 and January 2008.
S.-J. Du   +5 more
doaj   +1 more source

Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa [PDF]

open access: greenJournal of the American Chemical Society, 2017
A complex link exists between cell-wall recycling/repair and the manifestation of resistance to β-lactam antibiotics in many Enterobacteriaceae and Pseudomonas aeruginosa. This process is mediated by specific cell-wall-derived muropeptide products. These muropeptides are internalized into the cytoplasm and bind to the transcriptional regulator AmpR ...
David A. Dik   +10 more
openalex   +4 more sources

Mechanisms of ceftolozane/tazobactam resistance in Pseudomonas aeruginosa isolates from South Korea [PDF]

open access: yesPrecision and Future Medicine
Purpose This study aimed to identify ceftolozane/tazobactam (C/T)-resistant Pseudomonas aeruginosa isolates in Korea and to investigate the resistance mechanism.
Yu Mi Wi, So Yeon Kim, Kwan Soo Ko
doaj   +1 more source

Defining an optimal control for RNAi experiments with adult Schistosoma mansoni

open access: yesScientific Reports, 2023
In parasites such as Schistosoma mansoni, gene knockdown by RNA interference (RNAi) has become an indispensable tool for functional gene characterization. To distinguish target-specific RNAi effects versus off-target effects, controls are essential.
Max F. Moescheid   +4 more
doaj   +1 more source

Functional plasticity of antibacterial EndoU toxins. [PDF]

open access: yes, 2018
Bacteria use several different secretion systems to deliver toxic EndoU ribonucleases into neighboring cells. Here, we present the first structure of a prokaryotic EndoU toxin in complex with its cognate immunity protein.
Eschenfeldt, William H   +11 more
core   +1 more source

Single or in combination antimicrobial resistance mechanisms of Klebsiella pneumoniae contribute to varied susceptibility to different carbapenems. [PDF]

open access: yesPLoS ONE, 2013
Resistance to carbapenems has been documented by the production of carbapenemase or the loss of porins combined with extended-spectrum β-lactamases or AmpC β-lactamases.
Yu-Kuo Tsai   +4 more
doaj   +1 more source

Application of nitroarene dioxygenases in the design of novel strains that degrade chloronitrobenzenes. [PDF]

open access: yes, 2009
Widespread application of chloronitrobenzenes as feedstocks for the production of industrial chemicals and pharmaceuticals has resulted in extensive environmental contamination with these toxic compounds, where they pose significant risks to the health ...
Ju, Kou-San, Parales, Rebecca E
core   +1 more source

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