Results 61 to 70 of about 230,812 (335)
Advanced Science, EarlyView.Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen +14 more
wiley +1 more source
Ontological theory for ontological engineering: Biomedical systems information integration [PDF]
, 2004 Software application ontologies have the potential to become the keystone in state-of-the-art information management techniques. It is expected that these ontologies will support the sort of reasoning power required to navigate large and complex ...
Ceusters, Werner +3 more
core +1 more source
The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration. [PDF]
, 2015 The control of proliferation and differentiation by tumor suppressor genes suggests that evolution of divergent tumor suppressor repertoires could influence species regenerative capacity.
Ahituv, Nadav +3 more
core +1 more source
Advanced Science, EarlyView.Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou +15 more
wiley +1 more source
Stable fixation of an osseointegated implant system for above-the-knee amputees: titel RSA and radiographic evaluation of migration and bone remodeling in 55 cases. [PDF]
, 2012 Background and purposeRehabilitation of patients with transfemoral amputations is particularly difficult due to problems in using standard socket prostheses.
Antonellis, Anne +5 more
core +2 more sources
Scientific ReportsOsseointegration (OI), or bone-anchoring, of a prosthesis is a transformative procedure for addressing issues of socket fit among individuals with lower limb loss. Mechanically, the removal of the socket interface substantially alters the transmission of
Pawel R. Golyski +3 more
doaj +1 more source
AN AMPUTATION RETRACTOR. [PDF]
JAMA: The Journal of the American Medical Association, 1907 For years in doing amputations I have felt the need of some sort of efficient retractor to take the place of the two-tailed or three-tailed cloth retractor commonly used. The cloth sometimes holds the soft parts away from the saw, but frequently does not, the consequence being that the muscles are shredded or bruised enough to cause sloughing, or, on ...
openaire +3 more sources
Advanced Science, EarlyView.The mechanism diagram reveals that the formation of trauma‐induced heterotopic ossification (HO) is accompanied by the polarization of macrophages toward the M1 phenotype. Additionally, the extracellular vesicles secreted by M1 macrophages, which contain periostin (POSTN), directly bind to PTK7 in tendon‐derived stem cells (TDSCs).
Hang Liu +9 more
wiley +1 more source
Neurotrauma ReportsThe purpose of this study was to examine the relationship between sleep duration and clinical concussion assessments across concussion management timepoints in service academy cadets and midshipmen.
Michael J. Aderman +17 more
doaj +1 more source