Results 61 to 70 of about 216,547 (314)

Evaluation of Weight Change During Carboplatin Therapy in Dogs With Appendicular Osteosarcoma. [PDF]

, 2017
BackgroundThe prevalence of cancer cachexia in veterinary medicine has not been studied widely, and as of yet, no definitive diagnostic criteria effectively assess this syndrome in veterinary patients.Objectives(1) To determine the patterns of weight ...
Boston, SE, Culp, WTN, Kilkenny, JJ, Lu, X, Singh, A, Skorupski, KA, Story, AL, Woods, JP   +7 more
core   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Comparing the mechanical energetics of walking among individuals with unilateral transfemoral limb loss using socket and osseointegrated prosthetic interfaces

Scientific Reports
Osseointegration (OI), or bone-anchoring, of a prosthesis is a transformative procedure for addressing issues of socket fit among individuals with lower limb loss. Mechanically, the removal of the socket interface substantially alters the transmission of
Pawel R. Golyski, Benjamin K. Potter, Jonathan A. Forsberg, Brad D. Hendershot   +3 more
doaj   +1 more source

The clinical, radiological, microbiological, and molecular profile of the skin-penetration site of transfemoral amputees treated with bone-anchored prostheses. [PDF]

, 2017
The breach of the skin barrier is a critical issue associated with the treatment of individuals with transfemoral amputation (TFA) using osseointegrated, percutaneous titanium implants.
Berlin, Örjan, Brånemark, Rickard, Lennerås, Maria, Omar, Omar, Palmquist, Anders, Thomsen, Peter, Trobos, Margarita, Tsikandylakis, Georgios, Vazirisani, Forugh   +8 more
core   +1 more source

Promotion of DFU Wound Healing via BRG1–COL16A1 Axis in Fibroblasts

Advanced Science, EarlyView.
In normal wound healing, transcription factor BRG1 is upregulated and binds the COL16A1 promoter to enhance its expression, promoting fibroblast proliferation, migration, contraction, extracellular matrix deposition, and granulation tissue formation, thus accelerating wound closure.
Penghui Wang, Jiaming Sun, Ying Wang, Bichen Ren, Yuxin Liu, Yunhan Liu, Liang Chen, Lu Yu, Tao Dai, Li Yu, Zhihui Dong   +10 more
wiley   +1 more source

Disparities in Health and Health Care Among Medicare Beneficiaries [PDF]

, 2008
Compares disparities in treatments and health outcomes -- diabetes-related leg amputations, mammograms, diabetes management, primary care, and hospitalization rates -- by race/ethnicity and state or ...
Amitabh Chandra, David C. Goodman, Elliott S. Fisher   +2 more
core  

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Characterizing Everyday Locomotion Behaviors in Persons with Lower Limb Loss: A Month-Long Wearable Sensor Study

Applied Sciences
Monitoring mobility outcomes in real-world environments can provide a distinct perspective compared to traditional outcome measures obtained in laboratory or clinical settings, which may be limited by environmental factors or behavioral modification ...
Julian C. Acasio, Yisen Wang, Katherine Heidi Fehr, Brad D. Hendershot, Peter G. Adamczyk   +4 more
doaj   +1 more source

The oldest amputation on a Neolithic human skeleton in France [PDF]

, 2007
While 'surgical' practices such as trepanations are well attested since the first stages of the European Neolithic, the amputation of limbs in Prehistoric periods has not been well-documented until the case presented here. The particularly well-
Cecile Buquet-Marcon, Charlier Philippe, Samzun Anaick   +2 more
core   +1 more source

A Photothermal‐Responsive PRP‐Loaded Hydrogel Engineered With Composite Nanobottle for Controllable Delivery of Growth Factors and Multifunctional Therapy of Diabetic Wounds

Advanced Science, EarlyView.
A photothermal‐responsive engineered platelet‐rich plasma hydrogel (CNB‐ePRP) incorporated with thrombin‐functionalized composite nanobottle was developed, which enables in situ PRP activation, on‐demand growth factor release, multifunctionality, and personalized antimicrobial loading for treatment of diabetic wounds. The CNB‐ePRP hydrogel demonstrated
Wen‐Qiang Qu, Hui‐Yun Gu, Si‐Min Zeng, Chang‐Jiang Liu, Xiao Yan, Ting Pan, Chao Jian, Xian‐Zheng Zhang, Ai‐Xi Yu   +8 more
wiley   +1 more source