Results 221 to 230 of about 736,868 (299)

Calprotectin levels in Crohn's perianal fistula scraping are associated with fistula outcomes after surgical closure. [PDF]

Colorectal Dis
Pronk AJM, Beek KJ, Becker MAJ, Stoker J, Vlug MS, Bemelman WA, Wildenberg ME, Buskens CJ.   +7 more
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

An Optimized Diagnostic Approach for Adults With Suspected Inherited Metabolic Disorders. [PDF]

J Inherit Metab Dis
Oud MM, Ferreira EA, van Karnebeek CDM, Wijngaard R, Wolf NI, Engelen M, Datema M, Ferdinandusse S, van Kuilenburg ABP, Steinbusch L, van der Crabben SN, Langeveld M, ZOEMBA Study Group.   +12 more
europepmc   +1 more source

Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average‐Risk Populations, and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome and is characterized by an accelerated adenoma‐carcinoma sequence, a relatively higher prevalence of flat and subtle CRC precursor lesions, and exceptionally high adenoma miss rates despite intensive colonoscopy surveillance.
Robert Hüneburg, Querijn N. E. van Bokhorst, Evelien Dekker, Jacob Nattermann   +3 more
wiley   +1 more source

Innervation of the anal canal revisited through micro-CT imaging. [PDF]

J Anat
Docter D, Visser SC, Benninga MA, Hanemaaijer-van der Veer J, DeRuiter MC, Roelofs JJTH, Derikx JPM, de Jong JR, de Bakker BS, Gorter RR.   +9 more
europepmc   +1 more source

Colorectal Cancer Screening in Hereditary and Familial High‐Risk Populations: Best Practices and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related morbidity and mortality worldwide yet is largely preventable through effective screening and surveillance. While most CRC cases are sporadic, a substantial proportion occur in individuals at increased risk due to hereditary cancer syndromes or family history who require tailored
Ophir Gilad, Francesc Balaguer, Elizabeth E. Half, Kevin J. Monahan, Elena M. Stoffel, Sonia S. Kupfer   +5 more
wiley   +1 more source

Impact of Adopting the Race/Ethnicity-Free 2021 CKD-EPI Equation on Cardiovascular Risk Stratification in a Multiethnic European Population: Results from the HELIUS Study. [PDF]

Glob Heart
Huisman BJMV, Vosters TG, Agyemang C, van den Born BH, van Valkengoed IGM, Vogt L.   +5 more
europepmc   +1 more source

Association Between Socioeconomic Position and Diagnosis, Treatment and Survival of Patients With Stage I–III Rectal Cancer in the Netherlands

International Journal of Cancer, EarlyView.
ABSTRACT Socioeconomic position (SEP) influences cancer care and outcomes, even in countries with government‐funded healthcare. This population‐based study examined associations between SEP, rectal cancer care and survival of patients in the Netherlands.
Suzanne E. N. de Vries, Felice N. van Erning, Mieke J. Aarts, Alice M. Couwenberg, Laskarina J. K. Galanos, Irene E. G. van Hellemond, Ignace H. J. T. de Hingh, Robin Lurvink, Iris D. Nagtegaal, Johannes H. W. de Wilt, Marloes A. G. Elferink   +10 more
wiley   +1 more source

Splenic hilum nodal involvement in resected left-sided pancreatic cancer: meta-analysis. [PDF]

BJS Open
Bruna CL, Baggerman van Houweninge CE, Jamaludin FS, Malleo G, Abu Hilal M, Besselink MG, van Hilst J.   +6 more
europepmc   +1 more source

Tolerability of Adjuvant Nivolumab in Esophageal or Gastroesophageal Junction Cancer: A Real‐World Study

International Journal of Cancer, EarlyView.
ABSTRACT Adjuvant nivolumab is approved for esophageal or gastroesophageal junction cancer after neoadjuvant chemoradiotherapy and resection. In the CheckMate‐577 trial, Grade 3–5 nivolumab‐related adverse events (AEs) occurred in 5% of patients, with early discontinuation due to toxicity in 9%. However, real‐world data on immunotherapy‐related adverse
Michelle Koops van ’t Jagt, Anniek Strijdhorst, Tamara Jessica Huizer, Esther Albertien Kleibeuker, Sarah Derks, Bianca Mostert, Hanneke van Laarhoven, Jacco Juri de Haan   +7 more
wiley   +1 more source