Results 91 to 100 of about 279,658 (282)

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

Amygdala fMRI—A Critical Appraisal of the Extant Literature

Neuroscience Insights
Even before the advent of fMRI, the amygdala occupied a central space in the affective neurosciences. Yet this amygdala-centred view on emotion processing gained even wider acceptance after the inception of fMRI in the early 1990s, a landmark that ...
Tim Varkevisser, Elbert Geuze, Jack van Honk   +2 more
doaj   +1 more source

Visual search for basic emotional expressions in autism: impaired processing of anger, fear and sadness, but a typical happy face advantage [PDF]

, 2010
Facial expression recognition was investigated in 20 males with high functioning autism (HFA) or Asperger syndrome (AS), compared to typically developing individuals matched for chronological age (TD CA group) and verbal and non-verbal ability (TD V/NV ...
Abell, Adolphs, Amanda Branson, American Psychiatric Association, Annaz, Ashwin, Ashwin, Ashwin, Baird, Baron-Cohen, Baron-Cohen, Ben J. King, Boraston, Calvo, Calvo, Castelli, Critchley, Deruelle, Dunn, Eastwood, Ekman, Emily K. Farran, Fox, Frischen, Fusar-Poli, Grice, Hansen, Happé, Hobson, Hobson, Horstmann, Humphreys, Juth, Krysko, Leppanen, Njiokiktjien, Ozonoff, O’Riordan, Purcell, Raven, Sroufe, Vanger, Wallace   +42 more
core   +3 more sources

Amygdala

, 2007
The amygdala is made up of several heterogeneous nuclei in the medial temporal lobe. It is anatomically situated to receive a wide variety of processed sensory information from both the environment and body. It also has the requisite projections to influence virtually all the behavioral, autonomic and hormonal components of stress.
Fanselow, MS, Ponnusamy, R
openaire   +2 more sources

Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression [PDF]

, 2015
The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD.
Argibay, Pablo, Bassi, Sabrina Cecilia, Seney, Marianne L., Sibille, Etienne   +3 more
core   +1 more source

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

Associations between early trajectories of amygdala development and later school-age anxiety in two longitudinal samples

Developmental Cognitive Neuroscience
Amygdala function is implicated in the pathogenesis of autism spectrum disorder (ASD) and anxiety. We investigated associations between early trajectories of amygdala growth and anxiety and ASD outcomes at school age in two longitudinal studies: high ...
Catherine A. Burrows, Carolyn Lasch, Julia Gross, Jessica B. Girault, Joshua Rutsohn, Jason J. Wolff, Meghan R. Swanson, Chimei M. Lee, Stephen R. Dager, Emil Cornea, Rebecca Stephens, Martin Styner, Tanya St. John, Juhi Pandey, Meera Deva, Kelly N. Botteron, Annette M. Estes, Heather C. Hazlett, John R. Pruett, Jr., Robert T. Schultz, Lonnie Zwaigenbaum, John H. Gilmore, Mark D. Shen, Joseph Piven, Jed T. Elison   +24 more
doaj   +1 more source

Exploring Age-Related Changes in Resting State Functional Connectivity of the Amygdala: From Young to Middle Adulthood

Frontiers in Aging Neuroscience, 2018
Functional connectivities of the amygdala support emotional and cognitive processing. Life-span development of resting-state functional connectivities (rsFC) of the amygdala may underlie age-related differences in emotion regulatory mechanisms.
Ting Xiao, Ting Xiao, Sheng Zhang, Lue-En Lee, Herta H. Chao, Herta H. Chao, Christopher van Dyck, Christopher van Dyck, Christopher van Dyck, Chiang-Shan R. Li, Chiang-Shan R. Li, Chiang-Shan R. Li, Chiang-Shan R. Li   +12 more
doaj   +1 more source

Multi‐voxel pattern analysis of amygdala functional connectivity at rest predicts variability in posttraumatic stress severity

Brain and Behavior, 2020
Introduction Resting state functional magnetic resonance imaging (rsfMRI) studies demonstrate that individuals with posttraumatic stress disorder (PTSD) exhibit atypical functional connectivity (FC) between the amygdala, involved in the generation of ...
Jacklynn M. Fitzgerald, Emily L. Belleau, Tara A. Miskovich, Walker S. Pedersen, Christine L. Larson   +4 more
doaj   +1 more source