Results 81 to 90 of about 140,954 (249)

Multipathway modulation of neuroinflammation and oxidative stress by hesperidin in a rat single prolonged stress model of post‐traumatic stress disorder

Animal Models and Experimental Medicine, EarlyView.
Single prolonged stress (SPS) induces post‐traumatic stress disorder (PTSD)‐like neuropathology characterized by oxidative stress, neuroinflammation, astrocytic reactivity, neuronal damage, and reduced neurotrophic support in the hippocampus, amygdala, and prefrontal cortex. Hesperidin counteracts these effects by attenuating lipid peroxidation and pro‐
Godson Emeka Anyanwu, Ogan Christopher Akanaku, Augustine Oviosun, Precious E. Ekwueme, Paul Anyiom Odey, Chima Paul Okechukwu Ugwu, Chinyere Nkemjika Anyanwu   +6 more
wiley   +1 more source

The amygdala [PDF]

Current Biology, 2007
openaire   +3 more sources

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu, Weifeng Guo, Jianxiang Li, Tiange Zhang, Dan Xu   +4 more
wiley   +1 more source

Gut–Brain Axis Modulation by Short‐Chain Fatty Acids Exerts Disease‐Modifying Effects in a Murine Model of Drug‐Resistant Epilepsy

Annals of Neurology, EarlyView.
Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera, Rossella Di Sapia, Greta Volpedo, Sneha Anand, Eray Sahin, Pasquale Baldassarre, Francesca Buffelli, Andrea Petretto, Chiara Lavarello, James D. Mills, Gabriele Cattaneo, Ilaria Craparotta, Eleonora Aronica, Antonella Riva, Pasquale Striano, Annamaria Vezzani, Teresa Ravizza   +16 more
wiley   +1 more source

Comparative distribution of relaxin-3 inputs and calcium-binding protein-positive neurons in rat amygdala

Frontiers in Neuroanatomy, 2016
The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerful anatomical and molecular techniques, providing insights into the neural basis for anxiety disorders, depression, addiction,
Fabio N Santos, Celia W Pereira, Ana M Sanchez-perez, Marcos eOtero, Sherie K Ma, Andrew L Gundlach, Andrew L Gundlach, Francisco E Olucha-Bordonau   +7 more
doaj   +1 more source

Blood Biomarkers of Alzheimer's Disease and Patterns of Structural Brain Changes in the Community

Annals of Neurology, EarlyView.
Objective We aimed to investigate the associations between Alzheimer's disease (AD)‐related blood biomarkers and changes in brain volumes and cerebrovascular burden in community‐dwelling older adults. Methods We included 361 dementia‐free participants with a Mini‐Mental State Examination (MMSE) score ≥ 27 and without prior cerebrovascular events from a
Martina Valletta, Davide Liborio Vetrano, Erika J. Laukka, Grégoria Kalpouzos, Javier Oltra, Debora Rizzuto, Marco Canevelli, Claudia Fredolini, Chengxuan Qiu, Bengt Winblad, Laura Fratiglioni, Giulia Grande   +11 more
wiley   +1 more source

Associations between early trajectories of amygdala development and later school-age anxiety in two longitudinal samples

Developmental Cognitive Neuroscience
Amygdala function is implicated in the pathogenesis of autism spectrum disorder (ASD) and anxiety. We investigated associations between early trajectories of amygdala growth and anxiety and ASD outcomes at school age in two longitudinal studies: high ...
Catherine A. Burrows, Carolyn Lasch, Julia Gross, Jessica B. Girault, Joshua Rutsohn, Jason J. Wolff, Meghan R. Swanson, Chimei M. Lee, Stephen R. Dager, Emil Cornea, Rebecca Stephens, Martin Styner, Tanya St. John, Juhi Pandey, Meera Deva, Kelly N. Botteron, Annette M. Estes, Heather C. Hazlett, John R. Pruett, Jr., Robert T. Schultz, Lonnie Zwaigenbaum, John H. Gilmore, Mark D. Shen, Joseph Piven, Jed T. Elison   +24 more
doaj   +1 more source

Show Me the Brain!!: A modern approach to neuroanatomy education

Anatomical Sciences Education, EarlyView.
Abstract Show Me the Brain!! (SMtB) is a digital system for interactive graphics that is designed to support instruction in neuroanatomy and neuroscience. It will soon be made open‐source and freely available. SMtB bridges medical and traditional neuroanatomy instruction with the computational systems and representational conventions common in ...
Nicholas C. Hindy, Anthony J. Bishara, Ellie Lovellette, John R. Pani   +3 more
wiley   +1 more source

Tau-PET pathology in the subregions of the amygdala and its associations with cognitive performance and neuropsychiatric symptoms in autosomal dominant Alzheimer’s disease

Alzheimer’s Research & Therapy
Background The amygdala plays a role in behavior and emotional response and is vulnerable to Alzheimer’s disease (AD) pathology, yet little is known about amygdala tau accumulation before clinical symptom onset.
Catarina Tristão-Pereira, Stephanie Langella, Justin S. Sanchez, Vincent Malotaux, Bing He, Jorge Alcina, Jairo E. Martinez, Zoe Rubinstein, Ana Baena, Clara Vila-Castelar, Averi Giudicessi, Liliana Ramirez Gomez, Claudia Ramos, Daniel Vasquez, David Aguillon, Heidi I. L. Jacobs, Reisa A. Sperling, Keith Johnson, Jennifer R. Gatchel, Yakeel T. Quiroz   +19 more
doaj   +1 more source

Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Heterogeneity is a critical factor in understanding inter‐individual brain and behavioral variability in autism spectrum disorder (ASD). Since individuals with ASD exhibit atypical communication and social interaction skills closely linked to brain lateralization, this study investigated ASD heterogeneity using an asymmetry index that captures
Chae Yeon Kim, Sunghun Kim, Bo‐yong Park   +2 more
wiley   +1 more source