Results 41 to 50 of about 140,954 (249)

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Angst and the amygdala

Dialogues in Clinical Neuroscience, 2006
Fear is an adaptation to danger, but excessive fear underlies diverse forms of mental anguish and pathology. One neural site linked to a sense of adversity is the amygdala, and one neuropeptide, corticotropin-releasing hormone (CRH), is localized within the central nucleus of the amygdala. Glucocorticoids enhance the production of CRH in this region of
openaire   +3 more sources

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Primate Amygdalo-Nigral Pathway for Boosting Oculomotor Action in Motivating Situations

iScience, 2020
Summary: A primary function of the primate amygdala is to modulate behavior based on emotional cues. To study the underlying neural mechanism, we first inactivated the amygdala locally and temporarily by injecting a GABA agonist.
Kazutaka Maeda, Ken-ichi Inoue, Jun Kunimatsu, Masahiko Takada, Okihide Hikosaka   +4 more
doaj   +1 more source

Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Epilepsy affects > 50 million people worldwide and is associated with a disproportionate burden of cognitive impairment. Emerging evidence suggests that neurodegenerative proteinopathies, particularly hyperphosphorylated tau (p‐tau) and amyloid‐β (Aβ), may contribute to cognitive dysfunction in people with epilepsy (PWE), even in the absence ...
Syeda Amrah Hashmi, Aleksander Luniewski, Vanessa Smith, Matthew McCord, Jaideep Kapur, Mark Quigg, Catherine Joshua, Ifrah Zawar   +7 more
wiley   +1 more source

Sustained, not habituated, activity in the human amygdala: A pilot fMRI dot-probe study of attentional bias to fearful faces

Cogent Psychology, 2016
The human amygdala consciously and nonconsciously processes facial expressions and directs spatial attention to them. Research has shown that amygdala activity habituates after repeated exposure to emotionally salient stimuli during passive viewing tasks.
Millicent A. Weber, Kelly A. Morrow, Will S. Rizer, Keara J. Kangas, Joshua M. Carlson   +4 more
doaj   +1 more source

Maternal cortisol is associated with neonatal amygdala microstructure and connectivity in a sexually dimorphic manner

eLife, 2020
The mechanisms linking maternal stress in pregnancy with infant neurodevelopment in a sexually dimorphic manner are poorly understood. We tested the hypothesis that maternal hypothalamic-pituitary-adrenal axis activity, measured by hair cortisol ...
David Q Stoye, Manuel Blesa, Gemma Sullivan, Paola Galdi, Gillian J Lamb, Gill S Black, Alan J Quigley, Michael J Thrippleton, Mark E Bastin, Rebecca M Reynolds, James P Boardman   +10 more
doaj   +1 more source

Afraid of the dark: Light acutely suppresses activity in the human amygdala.

PLoS ONE, 2021
Light improves mood. The amygdala plays a critical role in regulating emotion, including fear-related responses. In rodents the amygdala receives direct light input from the retina, and light may play a role in fear-related learning.
Elise M McGlashan, Govinda R Poudel, Sharna D Jamadar, Andrew J K Phillips, Sean W Cain   +4 more
doaj   +1 more source

Hippocampal and amygdala volumetry by MRI in elderly with normal or mildly impaired cognition using FreeSurfer software

Journal of the Mexican Federation of Radiology and Imaging, 2023
Introduction. Decreased hippocampal and amygdala volume has been associated with cognitive impairment. This study compared hippocampal and amygdala volumes in older adults with normal cognition and mild cognitive impairment (MCI) using magnetic resonance
Paloma F. Vazquez-Jimenez, Monica Rios-Silva, Efren Murillo-Zamora, Jaime A. Bricio-Barrios, Oscar R. Marrufo-Melendez, Miguel Huerta   +5 more
doaj   +1 more source

Claustrum Involvement in New Onset Refractory Status Epilepticus: A Systematic Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The claustrum sign is a distinctive neuroimaging finding characterized by bilateral T2/FLAIR hyperintensity of the claustrum, one of the most interconnected regions of the human brain. It was first described in new‐onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES).
Margherita Burani, Lorenzo Muccioli, Giada Giovannini, Niccolò Orlandi, Francesca Bisulli, Stefano Meletti   +5 more
wiley   +1 more source