Results 221 to 230 of about 466,481 (267)

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Recent Insights Into Alzheimer's Disease: Advances in Pathophysiology and Therapeutic Strategies

Brain Health, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a complex neurodegenerative disorder driven by interplay among amyloid‐β (Aβ) plaques, tau neurofibrillary tangles, inflammation and comorbid pathologies. Recent advances in biomarkers and therapeutic approvals have reshaped our understanding of its pathophysiology and treatment landscape.
Jiong Shi, Jeffery Cummings, Jacques Touchon, Bruno Vellas   +3 more
wiley   +1 more source

A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice. [PDF]

Gut Microbes
Connell E, Le Gall G, McArthur S, Lang L, Breeze B, Liaquat M, Pontifex MG, Sami S, Pourtau L, Gaudout D, Müller M, Vauzour D.   +11 more
europepmc   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Neuroinflammation demonstrated by ¹¹C-ER176 PET with amyloid and tau pathology. [PDF]

Alzheimers Dement
Kandimalla M, Lim S, Jacobson DN, Lee J, Min PH, Nycklemoe ME, Lee SB, Lundt ES, Botha H, Graff-Radford J, Jones DT, Cogswell PM, Vemuri P, Kantarci K, Knopman DS, Jack CR, Petersen RC, Lowe VJ.   +17 more
europepmc   +1 more source

Sequence‐Dependent Heterotypic Assemblies of Intrinsically Disordered Peptides

ChemistryEurope, EarlyView.
Two oppositely charged intrinsically disordered peptides (IDPs) coassemble into heterotypic nanofibers. Homochiral mixtures (L/L IDPs) form homogeneous, aligned bundles with the more positive IDP. Heterochiral mixtures (L/D IDPs) yield heterogeneous, twisted bundles as positive‐IDP content increases.
Yuchen Qiao, Matthew Chu, Grace Wu, Zhiyu Liu, Bing Xu   +4 more
wiley   +1 more source

Modulation of islet amyloid polypeptide induced β-cell toxicity and amyloid formation by serum albumin proteins. [PDF]

Biophys Chem
Zhyvoloup A, Ridgway Z, Prashanth A, Raleigh DP.   +3 more
europepmc   +1 more source

Cu(I) Is a Game Changer in the Arrest of Cu(Aβ)‐Induced ROS Production in the Presence of Competing Zn(II) Ions

Chemistry – A European Journal, EarlyView.
ABSTRACT ROS production due to Cu(amyloid‐β) redox cycling is proposed to contribute to the oxidative stress observed in Alzheimer's disease brains. We previously reported on a nitrogen and sulfur‐containing ligand, L, able to arrest Cu(Aβ)‐induced ROS production [Chem. Eur. J. 2023, 29,].
Marielle Drommi, Kyangwi Patrick Malikidogo, Elena Atrián‐Blasco, Charlène Esmieu, Christelle Hureau   +4 more
wiley   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, EarlyView.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Form follows function: morphology as a map of mechanisms in neurodegenerative disease pathology. [PDF]

Free Neuropathol
Lee EB.
europepmc   +1 more source