Results 1 to 10 of about 112,225 (161)

The amyloid precursor protein: beyond amyloid

Molecular Neurodegeneration, 2006
The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and ...
Zheng Hui, Koo Edward H
doaj   +3 more sources

Biology and pathophysiology of the amyloid precursor protein [PDF]

Molecular Neurodegeneration, 2011
The amyloid precursor protein (APP) plays a central role in the pathophysiology of Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in the generation of β-amyloid peptides (Aβ).
Koo Edward H, Zheng Hui
doaj   +5 more sources

Tagged and untagged amyloid precursor protein E2 domain have comparable thermal stability and metal-ion binding propensity [PDF]

BMC Research Notes
Objective The amyloid precursor protein, central to the pathology of several disease including Alzheimer’s disease, cancer and obesity, represents a therapeutic target.
Zamaxasibe Nxele, Sphamandla Ndlovu, Candice Ngubane, Raymond Hewer, Alexandré Delport   +4 more
doaj   +2 more sources

Valosin-containing protein is cargo in Amyloid Precursor Protein extracellular vesicles [PDF]

Cell Communication and Signaling
The Amyloid Precursor Protein (APP), a genetic cause of Alzheimer’s disease (AD), is a type-I transmembrane protein that is metabolized by proteolysis in the endolysomal system. APP and its metabolites are secreted by cells in extracellular vesicles (EVs)
Yue Lu, Mohammad Abdullah, Liam R. Healy, Tao Yin, Metin Yesiltepe, Luciano D’Adamio, Marc D. Tambini   +6 more
doaj   +2 more sources

The Amyloid Precursor Protein Controls PIKfyve Function. [PDF]

PLoS ONE, 2015
While the Amyloid Precursor Protein (APP) plays a central role in Alzheimer's disease, its cellular function still remains largely unclear. It was our goal to establish APP function which will provide insights into APP's implication in Alzheimer's ...
Zita Balklava, Christian Niehage, Heather Currinn, Laura Mellor, Benjamin Guscott, Gino Poulin, Bernard Hoflack, Thomas Wassmer   +7 more
doaj   +4 more sources

The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein.

PLoS ONE, 2022
The amyloid cascade hypothesis proposes that excessive accumulation of amyloid beta-peptides is the initiating event in Alzheimer's disease. These neurotoxic peptides are generated from the amyloid precursor protein via sequential cleavage by β- and γ ...
Edward T Parkin, Jessica E Hammond, Lauren Owens, Matthew D Hodges   +3 more
doaj   +1 more source

Altered processing of amyloid precursor protein in cells undergoing apoptosis. [PDF]

PLoS ONE, 2013
Altered proteolysis of amyloid precursor protein is an important determinant of pathology development in Alzheimer's disease. Here, we describe the detection of two novel fragments of amyloid precursor protein in H4 neuroglioma cells undergoing apoptosis.
Tina Fiorelli, Lisa Kirouac, Jaya Padmanabhan   +2 more
doaj   +1 more source

Secretases Related to Amyloid Precursor Protein Processing

Membranes, 2021
Alzheimer’s disease (AD) is a common neurodegenerative disease whose prevalence increases with age. An increasing number of findings suggest that abnormalities in the metabolism of amyloid precursor protein (APP), a single transmembrane aspartic protein ...
Xiaoling Liu, Yan Liu, Shangrong Ji
doaj   +1 more source

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers [PDF]

Journal of Biological Chemistry, 2009
The amyloid precursor protein (APP) is implied both in cell growth and differentiation and in neurodegenerative processes in Alzheimer disease. Regulated proteolysis of APP generates biologically active fragments such as the neuroprotective secreted ectodomain sAPPalpha and the neurotoxic beta-amyloid peptide.
Gralle, Matthias, Botelho, Michelle Gralle, Wouters, Fred S.   +2 more
openaire   +5 more sources

Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin.

PLoS ONE, 2013
Dysregulation of the proteolytic processing of amyloid precursor protein by γ-secretase and the ensuing generation of amyloid-β is associated with the pathogenesis of Alzheimer's disease.
Nina Stemmer, Elena Strekalova, Nevena Djogo, Frank Plöger, Gabriele Loers, David Lutz, Friedrich Buck, Marek Michalak, Melitta Schachner, Ralf Kleene   +9 more
doaj   +1 more source