Results 1 to 10 of about 38,560 (119)
Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains
Neurobiology of Disease, 2002 Buoyant membrane fractions containing presenilin 1 (PS1), an essential component of the γ-secretase complex, and APP CTFβ, a γ-secretase substrate, can be isolated from cultured cells and brain by several different fractionation procedures that are ...
Andrew C Nyborg +2 more
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Secretases Related to Amyloid Precursor Protein Processing
Membranes, 2021 Alzheimer’s disease (AD) is a common neurodegenerative disease whose prevalence increases with age. An increasing number of findings suggest that abnormalities in the metabolism of amyloid precursor protein (APP), a single transmembrane aspartic protein ...
Xiaoling Liu, Yan Liu, Shangrong Ji
doaj +1 more source
Proteolytic Cleavage of Receptor Tyrosine Kinases
Biomolecules, 2021 The receptor tyrosine kinases (RTKs) are a large family of cell-surface receptors, which are essential components of signal transduction pathways. There are more than fifty human RTKs that can be grouped into multiple RTK subfamilies.
Hao Huang
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Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage
Frontiers in Molecular Neuroscience, 2023 Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder and the most common cause of dementia in the elderly. The presence of large numbers of senile plaques, neurofibrillary tangles, and cerebral atrophy is the characteristic feature ...
Yuji Kamikubo +6 more
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Microorganism-Derived Molecules as Enzyme Inhibitors to Target Alzheimer’s Diseases Pathways
Pharmaceuticals, 2023 Alzheimer’s disease (AD) is the most common form of dementia. It increases the risk of other serious diseases and causes a huge impact on individuals, families, and socioeconomics.
Thi Hanh Nguyen +2 more
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Synaptic and endosomal localization of active gamma-secretase in rat brain. [PDF]
PLoS ONE, 2010 A key player in the development of Alzheimer's disease (AD) is the gamma-secretase complex consisting of at least four components: presenilin, nicastrin, Aph-1 and Pen-2.
Susanne Frykman +7 more
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Frontiers in Neuroscience, 2018 The overwhelming majority of dominant mutations causing early onset familial Alzheimer’s disease (EOfAD) occur in only three genes, PSEN1, PSEN2, and APP.
Amanda L. Lumsden +7 more
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Molecules, 2021 γ-Secretase is an intramembrane aspartyl protease that is important in regulating normal cell physiology via cleavage of over 100 transmembrane proteins, including Amyloid Precursor Protein (APP) and Notch family receptors.
Alicia Ioppolo +4 more
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Human Papillomavirus L2 Capsid Protein Stabilizes γ-Secretase during Viral Infection
Viruses, 2022 Intracellular trafficking of human papillomavirus (HPV) during virus entry requires γ-secretase, a cellular protease consisting of a complex of four cellular transmembrane (TM) proteins. γ-secretase typically cleaves substrate proteins but it plays a non-
Mac Crite, Daniel DiMaio
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Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein
Cell Reports, 2016 Development of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides produced by β- and γ-secretase-mediated cleavage of the amyloid precursor protein (APP).
Saoussen Ben Halima +10 more
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