Cellular functions of gamma-secretase-related proteins [PDF]
, 2006 Amyloid-beta pepticle (A beta) is generated by gamma-secretase, a membrane protein complex with an unusual aspartyl protease activity consisting of the four components presenilin, nicastrin, APH-1 and PEN-2. Presenilin is considered the catalytic subunit
Haass, Christian, Haffner, Christof
core +1 more source
Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer’s disease
Translational Psychiatry, 2020 Rivastigmine (or Exelon) is a cholinesterase inhibitor, currently used as a symptomatic treatment for mild-to-moderate Alzheimer’s disease (AD). Amyloid-β peptide (Aβ) generated from its precursor protein (APP) by β-secretase (or BACE1) and γ-secretase ...
B. Ray +6 more
semanticscholar +1 more source
Gamma Secretase Modulators [PDF]
ACS Medicinal Chemistry Letters, 2013 Notes The authors declare no competing financial interest. Title: Gamma Secretase Modulators Application Number: WO 2013066740A1 Publication date: 10 May 2013 Priority Application: 61/553,384 Priority date: 31 October 2011 Inventors: W. Greenlee, D. Pissarnitski, Z. Zhao, Z.
openaire +2 more sources
The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease [PDF]
, 2016 Alzheimer’s disease (AD) is a highly complex, progressive, age-related neurodegenerative human disease entity. The genetic basis of AD is strictly connected with occurrence of mutations in Amyloid Precursor (APP) gene on chromosome 21.
Diehl, J. Alan +5 more
core +2 more sources
γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors
Frontiers in Aging Neuroscience, 2020 Described as the “proteasome of the membrane” or the “scissors in the membrane,” γ-secretase has notoriously complicated biology, and even after decades of research, the full extent of its regulatory mechanism remains unclear.
Eitan Wong +2 more
doaj +1 more source
Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo. [PDF]
PLoS ONE, 2011 Increase in the generation and deposition of amyloid-β (Aβ) plays a central role in the development of Alzheimer's Disease (AD). Elevation of the activity of γ-secretase, a key enzyme required for the generation for Aβ, can thus be a potential risk ...
Tong Li +5 more
doaj +1 more source
Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]
, 2009 The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core +1 more source
he amyloid hypothesis of Alzheimer's disease: past and present, hopes and disappointments
Неврология, нейропсихиатрия, психосоматика, 2019 In 1887, S.A. Belyakov, a physician of the Imperial Medical and Surgical Academy, first described amyloid deposits in the brain of patients with dementia. Later, in 1906, A.
I. V. Litvinenko +7 more
doaj +1 more source
BACE1 activity impairs neuronal glucose oxidation:rescue by beta-hydroxybutyrate and lipoic acid [PDF]
, 2015 Glucose hypometabolism and impaired mitochondrial function in neurons have been suggested to play early and perhaps causative roles in Alzheimer's disease (AD) pathogenesis. Activity of the aspartic acid protease, beta-site amyloid precursor protein (APP)
Arsenian +108 more
core +6 more sources
Gender- and age-dependent gamma-secretase activity in mouse brain and its implication in sporadic Alzheimer disease. [PDF]
PLoS ONE, 2009 Alzheimer disease (AD) is an age-related disorder. Aging and female gender are two important risk factors associated with sporadic AD. However, the mechanism by which aging and gender contribute to the pathogenesis of sporadic AD is unclear.
Lisa Placanica, Lei Zhu, Yue-Ming Li
doaj +1 more source