Results 1 to 10 of about 26,551 (120)

Liraglutide improves cognition function in streptozotocin-induced diabetic rats by downregulating β-secretase and γ-secretase and alleviating oxidative stress in HT-22 cells. [PDF]

Endocr J
Ma LY, Liu SF, Ma ZQ, Guo YG, Li M, Gao Y, Wen YT, Niu Y, Sui HX, Li BS, Li Y, Lv YL, Huang Y, Zhai JJ.   +13 more
europepmc   +1 more source

Conformational Changes and Unfolding of β-Amyloid Substrates in the Active Site of γ-Secretase. [PDF]

Int J Mol Sci
Jakowiecki J, Orzeł U, Miszta P, Młynarczyk K, Filipek S.   +4 more
europepmc   +1 more source

Single-cell analysis of the multiple myeloma microenvironment after γ-secretase inhibition and CAR T-cell therapy.

Blood
Coffey DG, Ataca Atilla P, Atilla E, Landgren O, Cowan AJ, Simon S, Pont MJ, Comstock ML, Hill GR, Riddell SR, Green DJ.   +10 more
europepmc   +1 more source

γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome. [PDF]

Ann Neurol
Chen XQ, Becker A, Albay R, Nguyen PD, Karachentsev D, Roberts AJ, Rynearson KD, Tanzi RE, Mobley WC.   +8 more
europepmc   +1 more source

Melatonin Supplementation Alleviates Impaired Spatial Memory by Influencing Aβ_1-42 Metabolism via γ-Secretase in the icvAβ_1-42 Rat Model with Pinealectomy. [PDF]

Int J Mol Sci
Georgieva I, Tchekalarova J, Nenchovska Z, Kortenska L, Tzoneva R.   +4 more
europepmc   +1 more source

Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1 , PSEN2 and APP causal genes

Gutiérrez Fernández S, Gan Oria C, Annaert W, Ringman JM, Fox NC, Ryan NS, Chávez-Gutiérrez L.   +6 more
europepmc   +1 more source

Structural basis of γ-secretase inhibition and modulation by small molecule drugs

Cell, 2021
Guanghui Yang, Rui Zhou, Xuefei Guo
exaly