Results 1 to 10 of about 40,728 (191)
Endogenous γ-Secretase Is Linked to Phagocytic Activity in Microglial Cells [PDF]
Sensorsγ-Secretase has primarily been studied in neurons, whereas increasing evidence highlights its importance in microglia. Previous research has shown that the pharmacological inhibition of γ-secretase impairs microglial phagocytic activity.
Emily Williams +6 more
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Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates [PDF]
Molecular Neurodegeneration, 2006 Background The mammalian Vps10p sorting receptor family is a group of 5 type I membrane homologs (Sortilin, SorLA, and SorCS1-3). These receptors bind various cargo proteins via their luminal Vps10p domains and have been shown to mediate a variety of ...
Nyborg Andrew C +4 more
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Recording γ-secretase activity in living mouse brains [PDF]
eLifeγ-Secretase plays a pivotal role in the central nervous system. Our recent development of genetically encoded Förster resonance energy transfer (FRET)-based biosensors has enabled the spatiotemporal recording of γ-secretase activity on a cell-by-cell ...
Steven S Hou +8 more
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Emerging structures and dynamic mechanisms of γ-secretase for Alzheimer’s disease [PDF]
Neural Regeneration Researchγ-Secretase, called “the proteasome of the membrane,” is a membrane-embedded protease complex that cleaves 150+ peptide substrates with central roles in biology and medicine, including amyloid precursor protein and the Notch family of cell-surface ...
Yinglong Miao, Michael S. Wolfe
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Charting γ-secretase substrates by explainable AI [PDF]
Nature CommunicationsProteases recognize substrates by decoding sequence information—an essential cellular process elusive when recognition motifs are absent. Here, we unravel this problem for γ-secretase, an intramembrane-cleaving protease associated with Alzheimer’s ...
Stephan Breimann +11 more
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Molecules, 2021 γ-Secretase is an intramembrane aspartyl protease that is important in regulating normal cell physiology via cleavage of over 100 transmembrane proteins, including Amyloid Precursor Protein (APP) and Notch family receptors.
Alicia Ioppolo +4 more
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Human Papillomavirus L2 Capsid Protein Stabilizes γ-Secretase during Viral Infection
Viruses, 2022 Intracellular trafficking of human papillomavirus (HPV) during virus entry requires γ-secretase, a cellular protease consisting of a complex of four cellular transmembrane (TM) proteins. γ-secretase typically cleaves substrate proteins but it plays a non-
Mac Crite, Daniel DiMaio
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BMC Research Notes, 2021 Objective NGFR/p75NTR and NRADD/NRH proteins are closely related structurally and are encoded by genes that arose from a duplication event early in vertebrate evolution.
Tanya Jayne +3 more
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eLife, 2020 γ-Secretase is a multi-subunit enzyme whose aberrant activity is associated with Alzheimer’s disease and cancer. While its structure is atomically resolved, γ-secretase localization in the membrane in situ relies mostly on biochemical data.
Abril Angélica Escamilla-Ayala +12 more
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Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo. [PDF]
PLoS ONE, 2011 Increase in the generation and deposition of amyloid-β (Aβ) plays a central role in the development of Alzheimer's Disease (AD). Elevation of the activity of γ-secretase, a key enzyme required for the generation for Aβ, can thus be a potential risk ...
Tong Li +5 more
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