Results 11 to 20 of about 40,728 (191)

The γ-secretase complex: from structure to function [PDF]

Frontiers in Cellular Neuroscience, 2014
One of the most critical pathological features of Alzheimer’s disease (AD) is the accumulation of β-amyloid (Aβ) peptides that form extracellular senile plaques in the brain. Aβ is derived from β-amyloid precursor protein through sequential cleavage by β-
Xian eZhang, Yanfang eLi, Huaxi eXu, Huaxi eXu, Yun-Wu eZhang   +4 more
doaj   +3 more sources

Hair Cell Generation in Cochlear Culture Models Mediated by Novel γ-Secretase Inhibitors [PDF]

Frontiers in Cell and Developmental Biology, 2021
Sensorineural hearing loss is prevalent within society affecting the quality of life of 460 million worldwide. In the majority of cases, this is due to insult or degeneration of mechanosensory hair cells in the cochlea. In adult mammals, hair cell loss is irreversible as sensory cells are not replaced spontaneously.
Silvia T. Erni, Silvia T. Erni, Silvia T. Erni, Silvia T. Erni, John C. Gill, Carlotta Palaferri, Carlotta Palaferri, Carlotta Palaferri, Gabriella Fernandes, Gabriella Fernandes, Gabriella Fernandes, Michelle Buri, Michelle Buri, Michelle Buri, Katherine Lazarides, Denis Grandgirard, Denis Grandgirard, Albert S. B. Edge, Albert S. B. Edge, Albert S. B. Edge, Stephen L. Leib, Stephen L. Leib, Marta Roccio, Marta Roccio, Marta Roccio, Marta Roccio   +25 more
openaire   +5 more sources

Complex regulation of γ-secretase: from obligatory to modulatory subunits [PDF]

Frontiers in Aging Neuroscience, 2015
γ-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid precursor protein (APP), catalyzing the formation of amyloid beta (Aβ) peptides that form amyloid plaques, which contribute to Alzheimer's disease (AD) pathogenesis. γ-Secretase also cleaves Notch, among many other type I transmembrane substrates.
Gertsik, Natalya, Chiu, Danica, Li, Yue-Ming   +2 more
openaire   +3 more sources

β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease [PDF]

Frontiers in Aging Neuroscience, 2014
Alzheimer's disease (AD) and vascular dementia are responsible for up to 90% of dementia cases. According to the World Health Organization (WHO), a staggering number of 35.6 million people are currently diagnosed with dementia. Blocking disease progression or preventing AD altogether is desirable for both social and economic reasons and recently focus ...
Menting, K.W., Claassen, J.A.H.R.
openaire   +3 more sources

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression [PDF]

Frontiers in Aging Neuroscience, 2015
Alzheimer's disease (AD) is characterized by an accumulation of Amyloid-β (Aβ), released by sequential proteolytic processing of the amyloid precursor protein (APP) by β - and γ-secretase. Aβ peptides can aggregate, leading to toxic Aβ oligomers and amyloid plaque formation.
Grimm, Marcus O. W., Mett, Janine, Stahlmann, Christoph P., Grösgen, Sven, Haupenthal, Viola J., Blümel, Tamara, Hundsdörfer, Benjamin, Zimmer, Valerie C., Mylonas, Nadine T., Tanila, Heikki, Müller, Ulrike, Grimm, Heike S., Hartmann, Tobias   +12 more
openaire   +3 more sources

Turning the tide on Alzheimer’s disease: modulation of γ-secretase

Cell & Bioscience, 2022
Alzheimer’s disease (AD) is the most common type of neurodegenerative disorder. Amyloid-beta (Aβ) plaques are integral to the “amyloid hypothesis,” which states that the accumulation of Aβ peptides triggers a cascade of pathological events leading to ...
Joanna E. Luo, Yue-Ming Li
doaj   +1 more source

γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors

Frontiers in Aging Neuroscience, 2020
Described as the “proteasome of the membrane” or the “scissors in the membrane,” γ-secretase has notoriously complicated biology, and even after decades of research, the full extent of its regulatory mechanism remains unclear.
Eitan Wong, Georgia R. Frost, Yue-Ming Li   +2 more
doaj   +1 more source

Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells

Biosensors, 2021
Presenilin (PS)/γ-secretase is an aspartyl protease that processes a wide range of transmembrane proteins such as the amyloid precursor protein (APP) and Notch1, playing essential roles in normal biological events and diseases.
Mei C. Q. Houser, Yuliia Turchyna, Florian Perrin, Lori Chibnik, Oksana Berezovska, Masato Maesako   +5 more
doaj   +1 more source

Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]

, 2009
L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Riedle, Svenja, Kiefel, Helena, Gast, Daniela, Bondong, Sandra, Wolterink, Silke, Gutwein, Paul, Altevogt, Peter   +6 more
core   +2 more sources

γ-secretase inhibitors and modulators induce distinct conformational changes in the active sites of γ-secretase and signal peptide peptidase [PDF]

, 2015
γ-Secretase inhibitors (GSIs) and modulators (GSMs) are at the frontline of cancer and Alzheimer’s disease research, respectively. While both are therapeutically promising, not much is known about their interactions with proteins other than γ-secretase ...
Chau, De Ming, Gertsik, Natalya, Li, Yue Ming   +2 more
core   +1 more source