The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells [PDF]
, 2015 INTRODUCTION: The A673T mutation in the amyloid precursor protein (APP) protects against Alzheimer’s disease by reducing β-amyloid protein (Aβ) production.
Asuka Kokawa +6 more
core +1 more source
The Alzheimer’s disease γ-secretase generates higher 42:40 ratios for β-amyloid than for p3 peptides [PDF]
, 2017 Alzheimer’s disease is characterized by intracerebral deposition of β-amyloid (Aβ). While Aβ40 is the most abundant form, neurotoxicity is mainly mediated by Aβ42.
Bruestle, Oliver +5 more
core +2 more sources
An exo-cell assay for examining real-time γ-secretase activity and inhibition
Molecular Neurodegeneration, 2009 γ-Secretase is an aspartyl protease that cleaves multiple substrates that are involved in broad biological processes ranging from stem cell development to neurodegeneration.
Tian Yuan +3 more
doaj +1 more source
Neurobiology of Disease, 2007 γ-Secretase is a protease complex, which catalyzes the final of two subsequent cleavages of the β-amyloid precursor protein (APP) to release the amyloid-β peptide (Aβ) implicated in Alzheimer’s disease (AD) pathogenesis.
Keiro Shirotani +4 more
doaj +1 more source
Visualization of PS/γ-Secretase Activity in Living Cells
iScience, 2020 Summary: A change in Presenilin (PS)/γ-secretase activity is linked to essential biological events as well as to the progression of many diseases. However, not much is known about how PS/γ-secretase activity is spatiotemporally regulated in cells. One of
Masato Maesako +5 more
doaj +1 more source
Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes. [PDF]
, 2015 BackgroundDendritic simplification, a key feature of the neurodegenerative triad of Alzheimer's disease (AD) in addition to spine changes and neuron loss, occurs in a region-specific manner.
Bakota, Lidia +5 more
core +1 more source
Inhibition of γ-secretase in adipocytes leads to altered IL-6 secretion and adipose inflammation
Adipocyte, 2020 Adipocyte-mediated inflammatory signalling has been proposed to alter adipose physiology in obesity and Type 2 diabetes mellitus. Novel targets for alteration of inflammatory signalling are needed to improve obesity-related outcomes.
David P. Sparling +3 more
doaj +1 more source
An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity. [PDF]
PLoS ONE, 2016 γ-secretase mediates the intramembranous proteolysis of amyloid precursor protein (APP) and determines the generation of Aβ which is associated with Alzheimer's disease (AD). Here we identified that an anti-Parkinson's disease drug, Istradefylline, could
Jing Lu +8 more
doaj +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Modulators of γ-secretase activity can facilitate the toxic side-effects and pathogenesis of Alzheimer's disease. [PDF]
PLoS ONE, 2013 BACKGROUND: Selective modulation of different Aβ products of an intramembrane protease γ-secretase, could be the most promising strategy for development of effective therapies for Alzheimer's disease.
Željko M Svedružić +2 more
doaj +1 more source