Results 11 to 20 of about 38,664 (219)
Membrane protein secretases [PDF]
Biochemical Journal, 1997 A diverse range of membrane proteins of Type I or Type II topology also occur as a circulating, soluble form. These soluble forms are often derived from the membrane form by proteolysis by a group of enzymes referred to collectively as ‘secretases‘ or ‘sheddases’.
N M, Hooper, E H, Karran, A J, Turner
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Intramembrane Proteolysis by γ-Secretase [PDF]
Journal of Biological Chemistry, 2008 Gamma-secretase mediates the final proteolytic cleavage, which liberates amyloid beta-peptide (Abeta), the major component of senile plaques in the brains of Alzheimer disease patients. Therefore, gamma-secretase is a prime target for Abeta-lowering therapeutic strategies.
Steiner, Harald +2 more
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eLife, 2020 γ-Secretase is a multi-subunit enzyme whose aberrant activity is associated with Alzheimer’s disease and cancer. While its structure is atomically resolved, γ-secretase localization in the membrane in situ relies mostly on biochemical data.
Abril Angélica Escamilla-Ayala +12 more
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BMC Research Notes, 2021 Objective NGFR/p75NTR and NRADD/NRH proteins are closely related structurally and are encoded by genes that arose from a duplication event early in vertebrate evolution.
Tanya Jayne +3 more
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Frontiers in Molecular Neuroscience, 2018 The competitive ectodomain shedding of amyloid-β precursor protein (APP) by α-secretase and β-secretase, and the subsequent regulated intramembrane proteolysis by γ-secretase are the key processes in amyloid-β peptides (Aβ) generation.
Xin Wang, Gang Pei, Gang Pei
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Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease
Frontiers in Molecular Neuroscience, 2020 Alzheimer’s disease (AD) is the most common type of senile dementia, characterized by neurofibrillary tangle and amyloid plaque in brain pathology. Major efforts in AD drug were devoted to the interference with the production and accumulation of amyloid ...
Jing Zhao +7 more
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γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors
Frontiers in Aging Neuroscience, 2020 Described as the “proteasome of the membrane” or the “scissors in the membrane,” γ-secretase has notoriously complicated biology, and even after decades of research, the full extent of its regulatory mechanism remains unclear.
Eitan Wong +2 more
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Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo. [PDF]
PLoS ONE, 2011 Increase in the generation and deposition of amyloid-β (Aβ) plays a central role in the development of Alzheimer's Disease (AD). Elevation of the activity of γ-secretase, a key enzyme required for the generation for Aβ, can thus be a potential risk ...
Tong Li +5 more
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Gamma Secretase Modulators [PDF]
ACS Medicinal Chemistry Letters, 2013 Notes The authors declare no competing financial interest. Title: Gamma Secretase Modulators Application Number: WO 2013066740A1 Publication date: 10 May 2013 Priority Application: 61/553,384 Priority date: 31 October 2011 Inventors: W. Greenlee, D. Pissarnitski, Z. Zhao, Z.
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he amyloid hypothesis of Alzheimer's disease: past and present, hopes and disappointments
Неврология, нейропсихиатрия, психосоматика, 2019 In 1887, S.A. Belyakov, a physician of the Imperial Medical and Surgical Academy, first described amyloid deposits in the brain of patients with dementia. Later, in 1906, A.
I. V. Litvinenko +7 more
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