Results 11 to 20 of about 86,542 (275)
Turning the tide on Alzheimer’s disease: modulation of γ-secretase
Cell & Bioscience, 2022 Alzheimer’s disease (AD) is the most common type of neurodegenerative disorder. Amyloid-beta (Aβ) plaques are integral to the “amyloid hypothesis,” which states that the accumulation of Aβ peptides triggers a cascade of pathological events leading to ...
Joanna E. Luo, Yue-Ming Li
semanticscholar +2 more sources
γ-Secretase in Alzheimer’s disease
Experimental & Molecular Medicine, 2022 Alzheimer’s disease (AD) is caused by synaptic and neuronal loss in the brain. One of the characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ).
J. Hur
semanticscholar +3 more sources
Recognition of the amyloid precursor protein by human γ-secretase
Science, 2019 Rui Zhou, Guanghui Yang, Xuefei Guo
exaly +2 more sources
Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions
Cell, 2017 Maria Szaruga +2 more
exaly +2 more sources
Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors.
New England Journal of Medicine, 2023 BACKGROUND Desmoid tumors are rare, locally aggressive, highly recurrent soft-tissue tumors without approved treatments. METHODS We conducted a phase 3, international, double-blind, randomized, placebo-controlled trial of nirogacestat in adults with ...
M. Gounder +40 more
semanticscholar +1 more source
Neuron, 2023 Presenilin mutations that alter γ-secretase activity cause familial Alzheimer's disease (AD), whereas ApoE4, an apolipoprotein for cholesterol transport, predisposes to sporadic AD. Both sporadic and familial AD feature synaptic dysfunction.
Sofia Essayan-Perez, T. Südhof
semanticscholar +1 more source
Secretases Related to Amyloid Precursor Protein Processing
Membranes, 2021 Alzheimer’s disease (AD) is a common neurodegenerative disease whose prevalence increases with age. An increasing number of findings suggest that abnormalities in the metabolism of amyloid precursor protein (APP), a single transmembrane aspartic protein ...
Xiaoling Liu, Yan Liu, Shangrong Ji
doaj +1 more source
EMBO Journal, 2021 Inflammation plays an important role in the pathogenesis of Alzheimer's disease (AD). Some evidence suggests that misfolded protein aggregates found in AD brains may have originated from the gut, but the mechanism underlying this phenomenon is not fully ...
Chun Chen +8 more
semanticscholar +1 more source
Proteolytic Cleavage of Receptor Tyrosine Kinases
Biomolecules, 2021 The receptor tyrosine kinases (RTKs) are a large family of cell-surface receptors, which are essential components of signal transduction pathways. There are more than fifty human RTKs that can be grouped into multiple RTK subfamilies.
Hao Huang
doaj +1 more source
Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage
Frontiers in Molecular Neuroscience, 2023 Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder and the most common cause of dementia in the elderly. The presence of large numbers of senile plaques, neurofibrillary tangles, and cerebral atrophy is the characteristic feature ...
Yuji Kamikubo +6 more
doaj +1 more source