Results 21 to 30 of about 175,143 (304)

Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions

Molecules, 2022
The amyloid hypothesis of Alzheimer’s disease has long been the predominant theory, suggesting that Alzheimer’s disease is caused by the accumulation of amyloid beta protein (Aβ) in the brain, leading to neuronal toxicity in the central nervous system ...
Chen Ma, Fenfang Hong, Shulong Yang
doaj   +1 more source

Interactions between amyloid, amyloid precursor protein, and mitochondria

Biochemical Society Transactions, 2023
Mitochondrial dysfunction and Aβ accumulation are hallmarks of Alzheimer's disease (AD). Decades of research describe a relationship between mitochondrial function and Aβ production. Amyloid precursor protein (APP), of which Aβ is generated from, is found within mitochondria.
openaire   +2 more sources

Amyloid precursor protein induces reactive astrogliosis

Acta Physiologica, 2023
AbstractAimAstrocytes respond to stressors by acquiring a reactive state characterized by changes in their morphology and function. Molecules underlying reactive astrogliosis, however, remain largely unknown. Given that several studies observed increase in the Amyloid Precursor Protein (APP) in reactive astrocytes, we here test whether APP plays a role
Gretsen Velezmoro Jauregui, Dragana Vukić, Isaac G. Onyango, Carlos Arias, Jan S. Novotný, Kateřina Texlová, Shanshan Wang, Kristina Locker Kovačovicova, Natalie Polakova, Jana Zelinkova, Maria Čarna, Valentina Lacovich Strašil, Brian P. Head, Daniel Havas, Martin Mistrik, Robert Zorec, Alexei Verkhratsky, Liam Keegan, Mary O’Connel, Robert Rissman, Gorazd B. Stokin   +20 more
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Amyloid precursor protein modulates β-catenin degradation

Journal of Neuroinflammation, 2007
Background The amyloid precursor protein (APP) is genetically associated with Alzheimer's disease (AD). Elucidating the function of APP should help understand AD pathogenesis and provide insights into therapeutic designs against this devastating ...
Chen Yuzhi, Bodles Angela M
doaj   +1 more source

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype.

PLoS ONE, 2016
The cellular prion protein (PrPC) has been proposed to play an important role in the pathogenesis of Alzheimer's disease. In cellular models PrPC inhibited the action of the β-secretase BACE1 on wild type amyloid precursor protein resulting in a ...
Isobel J Whitehouse, Deborah Brown, Herbert Baybutt, Abigail B Diack, Katherine A B Kellett, Pedro Piccardo, Jean C Manson, Nigel M Hooper   +7 more
doaj   +1 more source

A common beta-sheet architecture underlies in vitro and in vivo beta(2)-microglobulin amyloid fibrils [PDF]

, 2008
Misfolding and aggregation of normally soluble proteins into amyloid fibrils and their deposition and accumulation underlies a variety of clinically significant diseases.
Jahn, T.R., Radford, S.E., Tennent, G.A.
core   +2 more sources

Amyloid precursor protein and neural development [PDF]

Development, 2014
Interest in the amyloid precursor protein (APP) has increased in recent years due to its involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and biochemical work has focused on the role of APP in the pathogenesis of this disease. Thus far, however, these studies have failed to deliver successful therapies. This suggests
Maya, Nicolas, Bassem A, Hassan
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Regressive Autism Spectrum Disorder: High Levels of Total Secreted Amyloid Precursor Protein and Secreted Amyloid Precursor Protein-α in Plasma

Frontiers in Psychiatry, 2022
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication difficulties, repetitive behaviors, and parochial interests.
Xiaoli Li, Xiaoli Li, Xiaoli Li, Xiaoli Li, Xiaoli Li, Ping Zhou, Ping Zhou, Ping Zhou, Ping Zhou, Ping Zhou, Qiu Li, Qiu Li, Qiu Li, Qiu Li, Bin Peng, Yupeng Cun, Yupeng Cun, Yupeng Cun, Ying Dai, Ying Dai, Ying Dai, Ying Dai, Ying Dai, Hua Wei, Hua Wei, Hua Wei, Hua Wei, Hua Wei, Xiao Liu, Xiao Liu, Xiao Liu, Xiao Liu, Xiao Liu, Yang Yu, Yang Yu, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Qiongli Fan, Yuping Zhang, Ting Yang, Ting Yang, Ting Yang, Ting Yang, Ting Yang, Jie Chen, Jie Chen, Jie Chen, Jie Chen, Jie Chen, Qian Cheng, Qian Cheng, Qian Cheng, Qian Cheng, Qian Cheng, Tingyu Li, Tingyu Li, Tingyu Li, Tingyu Li, Tingyu Li, Li Chen, Li Chen, Li Chen, Li Chen, Li Chen   +66 more
doaj   +1 more source

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. [PDF]

, 2015
Deposition of potentially neurotoxic Aβ fragments derived from amyloid precursor protein (APP) at synapses may be a key contributor to Alzheimer's disease.
Goldstein, Lawrence SB, Niederst, Emily D, Reyna, Sol M   +2 more
core   +1 more source

Amyloid precursor protein processing and bioenergetics [PDF]

Brain Research Bulletin, 2017
The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form Aβ, and how Aβ generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to influence APP processing. Existing
Heather M. Wilkins, Russell H. Swerdlow
openaire   +2 more sources