Results 41 to 50 of about 120,581 (311)

Amyloid precursor protein in peripheral granulocytes as a potential biomarker for Alzheimer’s disease

Bangladesh Journal of Pharmacology, 2016
The aim of this study was to assess the potential of amyloid precursor protein in peripheral granulocytes as a diagnostic biomarker for early detection of Alzheimer’s disease.
Xiaonan Wang, Xihai Li, Jie Yang, Ming Yu, Jinmei Wu   +4 more
doaj   +2 more sources

Neuregulin-1 Exerts Protective Effects Against Neurotoxicities Induced by C-Terminal Fragments of APP via ErbB4 Receptor

Journal of Pharmacological Sciences, 2012
Neuregulin-1 (NRG1) plays important roles in the development and plasticity of the brain, and it is also reported to have potent neuroprotective properties.
Junghwa Ryu, Ha-Nul Yu, Harim Cho, Hye-Sun Kim, Tai-Kyoung Baik, Soo-Joo Lee, Ran-Sook Woo   +6 more
doaj   +1 more source

AMYPdb: A database dedicated to amyloid precursor proteins [PDF]

BMC Bioinformatics, 2008
Abstract Background Misfolding and aggregation of proteins into ordered fibrillar structures is associated with a number of severe pathologies, including Alzheimer's disease, prion diseases, and type II diabetes. The rapid accumulation of knowledge about the sequences and structures of these proteins allows using of ...
Sandrine Pawlicki, Antony Le Béchec, Christian Delamarche   +2 more
openaire   +5 more sources

Analysis of Toxic Amyloid Fibril Interactions at Natively Derived Membranes by Ellipsometry [PDF]

, 2015
There is an ongoing debate regarding the culprits of cytotoxicity associated with amyloid disorders. Although small pre-fibrillar amyloid oligomers have been implicated as the primary toxic species, the fibrillar amyloid material itself can also induce ...
Smith, Rachel A. S., Xue, Wei-Feng, Blakeman Ben J. F., Blakeman, Ben J. F., Smith, David P., Benjamin Abell (769585), Rachel A S Smith, David P. Smith (131751), Benjamin Abell, Wei-Feng Xue (610029), Ben J F Blakeman, Aleksey Nabok, David P Smith, Rachel A. S. Smith (769582), Smith Rachel A. S., Xue Wei-Feng, Nabok Aleksey, Abell Benjamin, Wei-Feng Xue, Ben J. F. Blakeman (769584), Abell, Benjamin, Aleksey Nabok (769583), Smith David P., Nabok, Aleksey, Leonenko, Zoya   +24 more
core   +1 more source

Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice

Neurobiology of Disease, 2005
Even though the idea that amyloid β peptide accumulation is the primary event in the pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link between aberrant amyloid precursor protein processing and tau alterations in this ...
Elena M. Ribé, Mar Pérez, Berta Puig, Ignasi Gich, Filip Lim, Mar Cuadrado, Teresa Sesma, Silvia Catena, Belén Sánchez, María Nieto, Pilar Gómez-Ramos, M.Asunción Morán, Felipe Cabodevilla, Lluis Samaranch, Lourdes Ortiz, Alberto Pérez, Isidro Ferrer, Jesús Avila, Teresa Gómez-Isla   +18 more
doaj   +1 more source

Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1 [PDF]

Journal of Biological Chemistry, 2004
Site-specific proteolysis of the amyloid-beta precursor protein (APP) by BACE 1 and gamma-secretase, a central event in Alzheimer disease, releases a large secreted extracellular fragment (called APP(S)), peptides of 40-43 residues derived from extracellular and transmembrane sequences (Abeta), and a short intracellular fragment (APP intracellular ...
Qiming, Li, Thomas C, Südhof
openaire   +2 more sources

Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH.

, 2002
BACKGROUND: One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Abeta, in the brain. Abeta arises from cleavage of the Amyloid Precursor protein by beta and gamma secretases, which present attractive candidates
Brian Austen, Liu, C, Austen, B, Chibuu Liu, Sidera, C, Christina Sidera   +5 more
core   +1 more source

Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage [PDF]

Proceedings of the National Academy of Sciences, 2004
Amyloid-β precursor protein (APP), a type I membrane protein, is physiologically processed by α- or β-secretases that cleave APP N-terminal to the transmembrane region. Extracellular α-/β-cleavage of APP generates a large secreted N-terminal fragment, and a smaller cellular C-terminal fragment.
Angela, Ho, Thomas C, Südhof
openaire   +2 more sources

Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression

Neural Regeneration Research, 2016
Rosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic and acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to up-regulate caveolin-1, inhibit ...
Yong-lin Zhao, Jin-ning Song, Xu-dong Ma, Bin-fei Zhang, Dan-dong Li, Hong-gang Pang   +5 more
doaj   +1 more source

Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models

Scientific Reports, 2021
Individuals who have Down syndrome (caused by trisomy of chromosome 21), have a greatly elevated risk of early-onset Alzheimer’s disease, in which amyloid-β accumulates in the brain. Amyloid-β is a product of the chromosome 21 gene APP (amyloid precursor
Justin L. Tosh, Elena R. Rhymes, Paige Mumford, Heather T. Whittaker, Laura J. Pulford, Sue J. Noy, Karen Cleverley, LonDownS Consortium, Matthew C. Walker, Victor L. J. Tybulewicz, Rob C. Wykes, Elizabeth M. C. Fisher, Frances K. Wiseman   +12 more
doaj   +1 more source