Results 1 to 10 of about 14,107 (263)

Pharmacokinetics in Rat of P8, a Peptide Drug Candidate for the Treatment of Alzheimer’s Disease: Stability and Delivery to the Brain

Journal of Alzheimer's Disease Reports, 2018
Strategies to achieve a therapy for Alzheimer’s disease (AD) aimed at reducing the effects of amyloid-β (Aβ) have largely involved inhibiting or modifying the activities of the β- or γ -secretases or by the use of monoclonal antibodies (MAb).
Nazneen N. Dewji, Marc R. Azar, Leah R. Hanson, William H. Frey II, Bruce H. Morimoto, David Johnson   +5 more
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Identification and characterization of Aβ peptide interactors in Alzheimer’s disease by structural approaches

Frontiers in Aging Neuroscience, 2014
Currently, there are very limited pharmaceutical interventions for Alzheimer’s disease (AD) to alleviate the amyloid burden implicated in the pathophysiology of the disease.
Keith D Philibert, Robert A Marr, Eric M Norstrom, Marc J Glucksman   +3 more
doaj   +1 more source

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein [PDF]

, 2008
Vivian Hook, Mark S. Kindy, Gregory Hook
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Decrease in p3‐Alcβ37 and p3‐Alcβ40, products of Alcadein β generated by γ‐secretase cleavages, in aged monkeys and patients with Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019
Introduction Neuronal p3‐Alcβ peptides are generated from the precursor protein Alcadein β (Alcβ) through cleavage by α‐ and γ‐secretases of the amyloid β (Aβ) protein precursor (APP).
Saori Hata, Chiori Omori, Ayano Kimura, Haruka Saito, Nobuyuki Kimura, Veer Gupta, Steve Pedrini, Eugene Hone, Pratishtha Chatterjee, Kevin Taddei, Kensaku Kasuga, Takeshi Ikeuchi, Masaaki Waragai, Masaki Nishimura, Anqi Hu, Tadashi Nakaya, Laurent Meijer, Masahiro Maeda, Tohru Yamamoto, Colin L. Masters, Chris C. Rowe, David Ames, Kazuo Yamamoto, Ralph N. Martins, Sam Gandy, Toshiharu Suzuki   +25 more
doaj   +1 more source

Neuroprotective role of MMP-9 overexpression in the brain of Alzheimer's 5xFAD mice

Neurobiology of Disease, 2014
Accumulation of amyloid-β (Αβ) peptide is believed to play a central role in the pathogenesis of Alzheimer's disease (AD). Lowering Aβ levels in the brain may thus improve synaptic and cognitive deficits observed in AD patients.
Apostolia Fragkouli, Effie C. Tsilibary, Athina K. Tzinia   +2 more
doaj   +1 more source

Genetic Targeting Aromatase in Male Amyloid Precursor Protein Transgenic Mice Down-Regulates β-Secretase (BACE1) and Prevents Alzheimer-Like Pathology and Cognitive Impairment [PDF]

, 2010
Carrie McAllister, Jiangang Long, Adrienne Bowers, Aaron Walker, Philip Cao, Shin-Ichiro Honda, Nobuhiro Harada, Matthias Staufenbiel, Yong Shen, Rena Li   +9 more
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Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation [PDF]

, 2023
István Hajdú, Barbara M. Végh, András Szilágyi, Péter Závodszky   +3 more
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Loss of Function of ATXN1 Increases Amyloid β-Protein Levels by Potentiating β-Secretase Processing of β-Amyloid Precursor Protein [PDF]

, 2010
Can Zhang, Andrew Browne, Daniel D. Child, Jason DiVito, Jesse A. Stevenson, Rudolph E. Tanzi   +5 more
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Constitutive α‐secretase cleavage of the β‐amyloid precursor protein in the furin‐deficient LoVo cell line: involvement of the pro‐hormone convertase 7 and the disintegrin metalloprotease ADAM10 [PDF]

, 2001
Elvira Lopez‐Perez, Yue Zhang, Stuart J. Frank, John W.M. Creemers, Nabil G. Seidah, Frédéric Checler   +5 more
openalex   +1 more source

Secretory phospholipase A2 type III enhances α-secretase-dependent amyloid precursor protein processing through alterations in membrane fluidity

Journal of Lipid Research, 2010
In the non-amyloidogenic pathway, amyloid precursor protein (APP) is cleaved by α-secretases to produce α-secretase-cleaved soluble APP (sAPPα) with neuroprotective and neurotrophic properties; therefore, enhancing the non-amyloidogenic pathway has been ...
Xiaoguang Yang, Wenwen Sheng, Yan He, Jiankun Cui, Mark A. Haidekker, Grace Y. Sun, James C-M. Lee   +6 more
doaj   +1 more source