Results 21 to 30 of about 14,107 (263)
γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing [PDF]
Journal of Cellular and Molecular Medicine, 2021 AbstractThe aggregation of β‐amyloid peptide 42 results in the formation of toxic oligomers and plaques, which plays a pivotal role in Alzheimer's disease pathogenesis. Aβ42 is one of several Aβ peptides, all of Aβ30 to Aβ43 that are produced as a result of γ‐secretase–mediated regulated intramembrane proteolysis of the amyloid precursor protein.
Tobias A. Weber +15 more
openaire +3 more sources
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease [PDF]
Alzheimer's Research & Therapy, 2010 Abstract Introduction Inhibition of gamma-secretase presents a direct target for lowering Aβ production in the brain as a therapy for Alzheimer's disease (AD). However, gamma-secretase is known to process multiple substrates in addition to amyloid precursor protein (APP), most notably Notch, which has ...
Guriqbal S. Basi +51 more
openalex +4 more sources
PLoS ONE, 2022 The amyloid cascade hypothesis proposes that excessive accumulation of amyloid beta-peptides is the initiating event in Alzheimer's disease. These neurotoxic peptides are generated from the amyloid precursor protein via sequential cleavage by β- and γ ...
Edward T Parkin +3 more
doaj +1 more source
A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase [PDF]
Communications Biology, 2022 AbstractHuman γ-secretase cleaves the transmembrane domains (TMDs) of amyloid precursor protein (APP) into pathologically relevant amyloid-β peptides (Aβs). The detailed mechanisms of the unique endoproteolytic cleavage by the presenilin 1 domain (PS1) of γ-secretase are still poorly understood.
Xiaoli Lu, Jing Huang
openalex +4 more sources
Cholesterol Modulates α-Secretase Cleavage of Amyloid Precursor Protein [PDF]
Journal of Biological Chemistry, 1996 Amyloid precursor protein (APP) and cholesterol metabolism are genetically linked to Alzheimer's disease, the latter through apolipoprotein E, a lipid and cholesterol transport protein. We have examined the hypothesis that the processing of APP is disrupted by elevated cholesterol, which is known to modulate the activity of several transmembrane ...
S, Bodovitz, W L, Klein
openaire +2 more sources
BMC Research Notes, 2021 Objective NGFR/p75NTR and NRADD/NRH proteins are closely related structurally and are encoded by genes that arose from a duplication event early in vertebrate evolution.
Tanya Jayne +3 more
doaj +1 more source
β-Amyloid Precursor Protein Mutants Respond to γ-Secretase Modulators [PDF]
Journal of Biological Chemistry, 2010 Pathogenic generation of the 42-amino acid variant of the amyloid beta-peptide (Abeta) by beta- and gamma-secretase cleavage of the beta-amyloid precursor protein (APP) is believed to be causative for Alzheimer disease (AD). Lowering of Abeta(42) production by gamma-secretase modulators (GSMs) is a hopeful approach toward AD treatment. The mechanism of
Page, Richard M +5 more
openaire +2 more sources
GDE2-RECK controls ADAM10 α-secretase–mediated cleavage of amyloid precursor protein [PDF]
Science Translational Medicine, 2021 GDE2 controls surface amounts of the metalloprotease inhibitor RECK to promote ADAM10 α-secretase activity and prevent Aβ production and synapse loss.
Nakamura, Mai +7 more
openaire +4 more sources
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source
Brain Ischemia as a Prelude to Alzheimer's Disease
Frontiers in Aging Neuroscience, 2021 Transient ischemic brain injury causes massive neuronal death in the hippocampus of both humans and animals. This was accompanied by progressive atrophy of the hippocampus, brain cortex, and white matter lesions.
Ryszard Pluta +2 more
doaj +1 more source