Results 11 to 20 of about 14,107 (263)

Secretases Related to Amyloid Precursor Protein Processing [PDF]

Membranes, 2021
Alzheimer’s disease (AD) is a common neurodegenerative disease whose prevalence increases with age. An increasing number of findings suggest that abnormalities in the metabolism of amyloid precursor protein (APP), a single transmembrane aspartic protein ...
Xiaoling Liu, Yan Liu, Shangrong Ji
doaj   +7 more sources

Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol [PDF]

Cell & Bioscience, 2023
Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating the effect of statins on lowering cholesterol suggest that there may be a link between cholesterol levels and AD pathology ...
Vladimir Rudajev, Jiri Novotny
doaj   +4 more sources

Interactions between APP secretases and inflammatory mediators [PDF]

Journal of Neuroinflammation, 2008
There is now a large body of evidence linking inflammation to Alzheimer's disease (AD). This association manifests itself neuropathologically in the presence of activated microglia and astrocytes around neuritic plaques and increased levels of ...
Gentleman Steve M, Walter Jochen, Sastre Magdalena   +2 more
doaj   +6 more sources

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. [PDF]

Nat Med, 2009
Amyloid-beta (Abeta) peptides, found in Alzheimer's disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either beta- or gamma-secretase, enzymes required for production of Abeta from amyloid precursor protein (APP), can ameliorate motor and cognitive deficits and reduce cell loss ...
Loane DJ, Pocivavsek A, Moussa CE, Thompson R, Matsuoka Y, Faden AI, Rebeck GW, Burns MP.   +7 more
europepmc   +6 more sources

Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury. [PDF]

Brain Res, 2014
Amyloid-β (Aβ) is produced through the enzymatic cleavage of amyloid precursor protein (APP) by β (Bace1) and γ-secretases. The accumulation and aggregation of Aβ as amyloid plaques is the hallmark pathology of Alzheimer׳s disease and has been found in other neurological disorders, such as traumatic brain injury and multiple sclerosis.
Pajoohesh-Ganji A, Burns MP, Pal-Ghosh S, Tadvalkar G, Hokenbury NG, Stepp MA, Faden AI.   +6 more
europepmc   +6 more sources

A synapse perspective on the function of the amyloid precursor protein [PDF]

Science Progress
The amyloid precursor protein (APP) is a transmembrane protein widely expressed throughout the brain, where it plays critical roles in both physiological and pathological states.
Pia Kruse, Amelie Eichler, Larissa Klukas, Maximilian Lenz   +3 more
doaj   +2 more sources

Secretase promotes AD progression: simultaneously cleave Notch and APP [PDF]

Frontiers in Aging Neuroscience
Alzheimer’s disease (AD) involves complex pathological mechanisms. Secretases include membrane protein extracellular structural domain proteases and intramembrane proteases that cleave the topology to type I or type II.
Ke-Fan Yang, Jing-Yi Zhang, Mei Feng, Kuo Yao, Yue-Yang Liu, Ming-Sheng Zhou, Hui Jia, Hui Jia   +7 more
doaj   +2 more sources

A perspective: PLA2G4A as drug target for vascular inflammation in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract Anti‐amyloid therapies for Alzheimer's disease (AD) modestly slow cognitive decline but carry significant risk of amyloid‐related imaging abnormalities (ARIAs), brain swelling, and hemorrhage, particularly in apolipoprotein E ε4 carriers. Cerebral amyloid angiopathy (CAA) and vascular inflammation drive this vulnerability, highlighting the ...
Kanwal A, Kerman BE, Wang S, Camey K, Li B, Flores-Aguilar L, Ali N, McIntire LB, Shu CA, Louie SG, Head E, Arvanitakis Z, Yassine HN.   +12 more
europepmc   +2 more sources

lncRNAs: key player in Aβ deposition [PDF]

RNA Biology
Alzheimer’s disease (AD) is a typical neurodegenerative disorder, characterized by the deposition of β-amyloid (Aβ) plaques. β- and γ-secretases generate Aβ by cleaving amyloid precursor protein.
Ruo-Mei Wang, Zi-Qiang Wang
doaj   +2 more sources

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation [PDF]

Nature Communications, 2012
In sporadic age-related forms of Alzheimer's disease (AD), it is unclear why amyloid-β (Aβ) peptides accumulate. Here we show that soluble amyloid precursor protein-α (sAPP-α) decreases Aβ generation by directly associating with β-site APP-converting enzyme (BACE)1, thereby modulating APP processing.
Demian Obregon, Huayan Hou, Juan Deng, Brian Giunta, Jun Tian, Donna Darlington, Md Shahaduzzaman, Yuyuan Zhu, Takashi Mori, Mark P. Mattson, Jun Tan   +10 more
openalex   +3 more sources