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Biomolecular mechanisms of cardiac amyloidosis and its cardiovascular pathological basis. [PDF]
Front ImmunolZhang L, Jiao Y, Guo J.
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Differential A-to-I editing of SINE B2 RNAs unveils an epitranscriptome response to Aβ neurotoxicity. [PDF]
Life Sci AllianceMitchell L +9 more
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Heart, Lung and Circulation, 2020
Amyloid cardiomyopathy is emerging as an important and under-recognised cause of heart failure and cardiac arrhythmias, especially in older adults. This disorder is characterised by extracellular deposition of amyloid fibrils that form due to misfolding of secreted light chains (AL) or transthyretin protein (ATTR). In ATTR, amyloid aggregates typically
Nicole K. Bart +5 more
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Amyloid cardiomyopathy is emerging as an important and under-recognised cause of heart failure and cardiac arrhythmias, especially in older adults. This disorder is characterised by extracellular deposition of amyloid fibrils that form due to misfolding of secreted light chains (AL) or transthyretin protein (ATTR). In ATTR, amyloid aggregates typically
Nicole K. Bart +5 more
openaire +5 more sources
Function of amyloid and amyloid protein precursor
Clinical Neurology and Neurosurgery, 1992A short review is given of the functions of amyloid (beta/A4) and its precursor protein (APP). The possible relationship between amyloid deposition and dementia is discussed.
R A, Roos, J, Haan
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Degradation of Serum Amyloid A in Amyloid‐Susceptible and Amyloid‐Resistant Mouse Strains
Scandinavian Journal of Immunology, 1996Degradation of serum amyloid A (apoSAA) by resident peritoneal cells (RPCS) and conditioned medium (CDM), prepared with RPCS, from amyloid‐susceptible CBA/J mice, amyloid‐resistant CE/J mice and their amyloid‐resistant CBA/J × CE/J F1 progeny was investigated in vitro.
R, Elliott-Bryant +3 more
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Digestive Diseases, 2008
The systemic amyloidoses are serious and potentially fatal disorders caused by deposition of autologous proteins in an abnormal fibrilllar from. The clinical features are highly variable but gut involvement is common and random gastrointestinal biopsies are diagnostic in 80% of patients.
L B, Lovat, M B, Pepys, P N, Hawkins
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The systemic amyloidoses are serious and potentially fatal disorders caused by deposition of autologous proteins in an abnormal fibrilllar from. The clinical features are highly variable but gut involvement is common and random gastrointestinal biopsies are diagnostic in 80% of patients.
L B, Lovat, M B, Pepys, P N, Hawkins
openaire +2 more sources
Current Cardiology Reports, 2019
While morbidity and mortality remain high for amyloid cardiomyopathy (AC), increased awareness, earlier diagnosis, and advances in treatment have improved patient outcomes. This review will discuss the pathophysiology, contemporary diagnostic strategies, and novel and investigational therapeutic strategies for light-chain (AL) and transthyretin (ATTR ...
Aaron M, Wolfson +2 more
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While morbidity and mortality remain high for amyloid cardiomyopathy (AC), increased awareness, earlier diagnosis, and advances in treatment have improved patient outcomes. This review will discuss the pathophysiology, contemporary diagnostic strategies, and novel and investigational therapeutic strategies for light-chain (AL) and transthyretin (ATTR ...
Aaron M, Wolfson +2 more
openaire +2 more sources