Results 101 to 110 of about 384,012 (260)

Therapeutic Efficacy and Safety Profile of Eplontersen in Hereditary Transthyretin‐Mediated Amyloidosis: A Systematic Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Hereditary transthyretin‐mediated amyloidosis (hATTR) is a disorder that affects several body systems and can result in life‐threatening conditions like cardiomyopathy and polyneuropathy. For treatment of hATTR in the new medical realm, there is a breakthrough discovery of a medicine called Eplontersen, which targets the underlying ...
Zeel Vishnubhai Patel, Verkha Kumari, Paras, Bethineedi Lakshmi Deepak, Priyadarshi Prajjwal, Kolanu Nikhil Deep, Rakhi Bai, Serene Sara John, Omniat Amir Hussin   +8 more
wiley   +1 more source

Rationale, application and clinical qualification for NT-proBNP as a surrogate end point in pivotal clinical trials in patients with AL amyloidosis [PDF]

, 2016
Amyloid light-chain (LC) amyloidosis (AL amyloidosis) is a rare and fatal disease for which there are no approved therapies. In patients with AL amyloidosis, LC aggregates progressively accumulate in organs, resulting in organ failure that is ...
Ando, Y, Comenzo, RL, Dispenzieri, A, Gertz, MA, Grogan, M, Lousada, I, Maurer, MS, Merlini, G, Palladini, G, Sanchorawala, V, Wechalekar, A   +10 more
core   +1 more source

Breakthrough advances enhancing care in ATTR amyloid cardiomyopathy.

European journal of internal medicine
Transthyretin amyloid cardiomyopathy (ATTR-CM) has been traditionally considered a rare and inexorably fatal condition. ATTR-CM now is an increasingly recognized cause of heart failure (HF) and mortality worldwide with effective pharmacological ...
A. Porcari, G. Sinagra, J. Gillmore, M. Fontana, P. Hawkins   +4 more
semanticscholar   +1 more source

Atrial cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 727-729, April 2025.
Wojciech Kosmala, Monika Przewłocka‐Kosmala   +1 more
wiley   +1 more source

Conservative Management of Bilateral Spontaneous Pneumothorax

Respirology Case Reports, Volume 14, Issue 3, March 2026.
Bilateral simultaneous spontaneous pneumothorax is a rare occurrence that generally requires prompt intervention. We report a case of simultaneous bilateral spontaneous pneumothorax that was conservatively managed. ABSTRACT Bilateral simultaneous spontaneous pneumothorax is a rare occurrence that generally requires prompt intervention. We report a case
Hanson Siu, Chuan T. Foo
wiley   +1 more source

Cardiac Resynchronization Therapy, Remodeling, and Outcome in Patients With Amyloid Transthyretin Cardiomyopathy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Transthyretin amyloid cardiomyopathy (ATTR‐CM) has a specific pathophysiology, with myocardial stiffening and systolic dysfunction only in advanced stages. We aimed to investigate the response to cardiac resynchronization therapy (CRT) in ATTR‐
Alberto Aimo, Martina Nesti, Giuseppe Vergaro, Ammar M. Killu, Dimitrios Bampatsias, Daniela Tomasoni, Cinzia Forleo, Francesco Musca, Matteo Serenelli, Julie Rosenthal, Sergio L. Teruya, Nader J. Al‐Shakarchi, Mariel S. Tameze, Vincenzo Castiglione, Alessio Nicolai, Giorgia Panichella, Riccardo Saro, Aldostefano Porcari, Giulio Sinigiani, Vera Fico, Elisa Frau, Reem Matar, Andrea I. Guaricci, Giacomo Tini, Alberto Cipriani, Maria B. Musumeci, Simone Longhi, Cristina Chimenti, Marco Metra, Martha Grogan, Federico Perfetto, Francesco Cappelli, Marco Merlo, Gianfranco Sinagra, Mathew S. Maurer, Ahmad Masri, Michele Emdin   +36 more
doaj   +1 more source

A simple voltage/mass index increases the suspicion of amyloidotic cardiomyopathy: an electrocardiographic and echocardiographic study of 767 patients with increased left ventricular wall thickness due to different causes [PDF]

, 2015
Background-Amyloidotic cardiomyopathy (AC) can mimic true left ventricular hypertrophy (LVH), including hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD).
Quarta, Candida Cristina <1981>
core   +1 more source

Leveraging the ADAM10 prodomain for selective inhibition to enhance recovery after myocardial infarction

British Journal of Pharmacology, Volume 183, Issue 5, Page 990-1008, March 2026.
Background and Purpose Inflammation plays a crucial role in the development and progression of numerous acute and chronic diseases such as myocardial infarction (MI) and heart failure. Targeting ADAM proteases, particularly ADAM10, holds promise for fine‐tuning inflammatory responses.
Erik Klapproth, Johanna Marks, Patrick Diaba‐Nuhoho, Sören Grell, Paul Leubauer, Susanne Kämmerer, Johannes R. Soltwedel, Fred Rasmussen, Felix Mejia, Marcia L. Moss, Christopher Prince, Peter Mirtschink, Ben Wielockx, Paul Saftig, Michael Wagner, Kristina Lorenz, Ali El‐Armouche   +16 more
wiley   +1 more source

AMPK in the central nervous system: physiological roles and pathological implications [PDF]

, 2016
5′ AMP-activated protein kinase (AMPK) is considered the master metabolic regulator in all eukaryotes, as it maintains cellular energy homeostasis in a variety of tissues, including the brain.
Fioramonti, Marco, Fracassi, Anna, Marangoni, Martina, Rosso, Pamela, Segatto, Marco, Siteni, Silvia, Taglietti, Valentina   +6 more
core   +1 more source

Diagnostic Utility of Relative Apical Sparing Index in Cardiac Amyloidosis Subtypes: A Comparative Study of Immunoglobulin Light Chain and Transthyretin Amyloid Cardiomyopathy

Echocardiography
Speckles tracking echocardiography imaging enables clinicians to detect subtle systolic dysfunction. The aim of the present study was to elucidate the differences in speckle tracking echocardiographic findings between immunoglobulin light chain amyloid ...
Y. Saijo, H. Yamada, N. Yamaguchi, S. Nishio, R. Zheng, Tomonori Takahashi, T. Hara, M. Kadota, Y. Kawabata, R. Ueno, T. Matsuura, T. Ise, K. Yamaguchi, S. Yagi, T. Soeki, T. Wakatsuki, Masataka Sata   +16 more
semanticscholar   +1 more source