Results 111 to 120 of about 288,605 (343)

Amyloid-like fibrils labeled with magnetic nanoparticles

Biomolecular Concepts, 2013
A number of human diseases are associated with the formation of insoluble protein aggregates commonly known as amyloid fibrils or amyloid plaques. Similar materials can be prepared in vitro resulting in so-called amyloid-like fibrils. Herein is discussed
Solin Niclas
doaj   +1 more source

[Transthyretin amyloid cardiomyopathy].

Ugeskrift for læger
Transthyretin amyloidosis (ATTR-CM) is an infiltrative cardiomyopathy caused by the deposition of amyloid fibrils, leading to heart failure, arrhythmias, and increased mortality. ATTR-CM prevalence is rising.
S. Fensman, Ale Hussein Jaber Mejren, T. Clemmensen, S. H. Poulsen   +3 more
semanticscholar   +1 more source

Amyloid plaque structure and cell surface interactions of β-amyloid fibrils revealed by electron tomography

Scientific Reports, 2017
The deposition of amyloid fibrils as plaques is a key feature of several neurodegenerative diseases including in particular Alzheimer’s. This disease is characterized, if not provoked, by amyloid aggregates formed from Aβ peptide that deposit inside the ...
Shen Han, M. Kollmer, D. Markx, S. Claus, P. Walther, M. Fändrich   +5 more
semanticscholar   +1 more source

Structural analysis of ex vivo amyloid fibrils from AL amyloidosis

, 2023
The disease AL amyloidosis is caused by the misfolding of immunoglobulin light chains (LC). Due to an underlying plasma cell dyscrasia, amyloidogenic LCs are overproduced and their high serum concentrations lead to aggregation and amyloid fibril ...
Radamaker, Lynn
core   +1 more source

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source

Thermodynamic Characterisation of Amyloid Fibrils

, 2022
Amyloid fibril related diseases include dementia, Alzheimer’s disease and Parkinsons disease and pose an increasingly large burden to global healthcare, due to the presence of an ageing population.

core   +2 more sources

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

The question of strains in AA amyloidosis

Scientific Reports
The existence of transmissible amyloid fibril strains has long intrigued the scientific community. The strain theory originates from prion disorders, but here, we provide evidence of strains in systemic amyloidosis.
Gunilla T. Westermark, Ebba Nyström, Sofie Nyström, K. Peter R. Nilsson, Per Hammarström, Per Westermark   +5 more
doaj   +1 more source

Toxic species in amyloid disorders: Oligomers or mature fibrils

Annals of Indian Academy of Neurology, 2015
Protein aggregation is the hallmark of several neurodegenerative disorders. These protein aggregation (fibrillization) disorders are also known as amyloid disorders. The mechanism of protein aggregation involves conformation switch of the native protein,
Meenakshi Verma, Abhishek Vats, Vibha Taneja   +2 more
doaj   +1 more source

Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia

, 2001
Familial British dementia (FBD), pathologically characterized by cerebral amyloid angiopathy (CAA), amyloid plaques, and neurofibrillary degeneration, is associated with a stop codon mutation in the BRI gene resulting in the production of an ...
Tammaryn Lashley, Ghiso, J, Vidal, R, Ayling, H., Gibb, G, Anderton, B H, Hilary Ayling, Rostagno, A., Anderton, B.H., Plant, G., Janice L. Holton, Tamas Revesz, Revesz, T, Martinian, L, Henry Houlden, Ruben Vidal, Nicholas W. Wood, Lashley, T, Revesz, T., Frangione, B., Jorge Ghiso, Ayling, H, Holton, J.L., Christopher J. Guerin, Houlden, H, Plant, G, Holton, J L, Gordon Plant, Rostagno, A, Lashle, T., Gibb, G., Lillian Martinian, Ghiso, J., Graham Gibb, Martinian, L., Brian H. Anderton, Agueda Rostagno, Houlden, H., Wood, N.W., Frangione, B, Vidal, R., Guerin, C J, Wood, N W, Guerin, C.J., Blas Frangione   +44 more
core   +1 more source