Results 11 to 20 of about 288,605 (343)
PLoS ONE, 2014 Amyloid fibrils are associated with many maladies, including Alzheimer's disease (AD). The isolation of amyloids from natural materials is very challenging because the extreme structural stability of amyloid fibrils makes it difficult to apply ...
Erin R Greiner +2 more
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Cytochrome Display on Amyloid Fibrils
Journal of the American Chemical Society, 2006 Protein amyloid fibrils can be functionalized by coating the core protofilament with high concentrations of proteins and enzymes. This can be done elegantly by appending a functional domain to an amyloidogenic protein monomer, then assembling the monomers into a fibril. To display an array of biologically functional porphyrins on the surface of protein
Baldwin, A +5 more
openaire +4 more sources
Pathway Dependence of the Formation and Development of Prefibrillar Aggregates in Insulin B Chain
Molecules, 2022 Amyloid fibrils have been an important subject as they are involved in the development of many amyloidoses and neurodegenerative diseases. The formation of amyloid fibrils is typically initiated by nucleation, whereas its exact mechanisms are largely ...
Yuki Yoshikawa +10 more
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bioRxiv, 2022 Understanding of the molecular mechanisms underlying the maturation of protein condensates into amyloid fibrils associated with neurodegenerative diseases has so far remained elusive. Now it has been shown that in condensates formed by the low-complexity
Miriam Linsenmeier +9 more
semanticscholar +1 more source
Endocytosed 2-Microglobulin Amyloid Fibrils Induce Necrosis and Apoptosis of Rabbit Synovial Fibroblasts by Disrupting Endosomal/Lysosomal Membranes: A Novel Mechanism on the Cytotoxicity of Amyloid Fibrils. [PDF]
PLoS ONE, 2015 Dialysis-related amyloidosis is a major complication in long-term hemodialysis patients. In dialysis-related amyloidosis, β2-microglobulin (β2-m) amyloid fibrils deposit in the osteoarticular tissue, leading to carpal tunnel syndrome and destructive ...
Tadakazu Okoshi +4 more
doaj +1 more source
Self-Assembly of Amyloid Fibrils into 3D Gel Clusters versus 2D Sheets
Biomolecules, 2023 The deposition of dense fibril plaques represents the pathological hallmark for a multitude of human disorders, including many neurodegenerative diseases.
Kanchana Karunarathne +7 more
doaj +1 more source
Small molecule targeting amyloid fibrils inhibits Streptococcus mutans biofilm formation
AMB Express, 2021 Amyloid fibrils are important scaffold in bacterial biofilms. Streptococcus mutans is an established cariogenic bacteria dwelling within biofilms, and C123 segment of P1 protein is known to form amyloid fibrils in S.
Yuanyuan Chen +4 more
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Amyloid Fibril Solubility [PDF]
The Journal of Physical Chemistry B, 2015 It is well established that amyloid fibril solubility is protein specific, but how solubility depends on the interactions between the fibril building blocks is not clear. Here we use a simple protein model and perform Monte Carlo simulations to directly measure the solubility of amyloid fibrils as a function of the interaction between the fibril ...
Rizzi, LG, Auer, S
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Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes. [PDF]
PLoS ONE, 2015 Light chain (AL) amyloidosis is the most common form of systemic amyloid disease, and cardiomyopathy is a dire consequence, resulting in an extremely poor prognosis.
Helen P McWilliams-Koeppen +12 more
doaj +1 more source
Plasticity of Amyloid Fibrils [PDF]
Biochemistry, 2006 In experiments designed to characterize the basis of amyloid fibril stability through mutational analysis of the Abeta (1-40) molecule, fibrils exhibit consistent, significant structural malleability. In these results, and in other properties, amyloid fibrils appear to more resemble plastic materials generated from synthetic polymers than globular ...
Ronald, Wetzel +2 more
openaire +2 more sources