Results 71 to 80 of about 319,403 (201)

Amyloid neuropathy in multiple myeloma and other plasma cell dyscrasias : a hypothesis of the pathogenesis of amyloid neuropathies

, 1983
The development of amyloid neuropathy is an uncommon complication of multiple myeloma. The clinical, electrophysiological and pathological features of 3 such patients are described.
K. P. McAdam, Verghese, Jacob P, McAdam, Keith P.W.J, Bradley, Walter G, R. Nemni, Nemni, Raffaello, J. P. Verghese, W. G. Bradley   +7 more
core   +1 more source

Consequences of the interaction of amyloid beta with amyloid binding alcohol dehydrogenase and the receptor for advanced glycation end products [PDF]

, 2008
Amyloid beta (Aβ) has been postulated to be the principle initiator of the pathogenesis of Alzheimer’s disease (AD). Therefore, understanding the underlying mechanisms of Aβ induced neurotoxicity in the early stages of AD would be essential for finding ...
Ren, Yimin
core   +2 more sources

Quality of Life Following Liver Transplantation in Patients With Familial Amyloid Neuropathy: A Prospective Controlled Study

Psychology, Community & Health, 2014
Aim: The present study aimed to evaluate the change in quality of life 12 months following liver transplantation in patients with Familial Amyloid Polyneuropathy (FAP). Method: In this study 150 transplant candidates, attending the outpatient clinic of a Liver Transplantation Centre in Lisbon, were assessed between March 1, 2006 and December 1, 2007 ...
Telles-Correia, Diogo, Barbosa, António, Mega, Inês, Monteiro, Estela, Barroso, Eduardo   +4 more
openaire   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, Volume 15, Issue 36, 25 September 2026.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, Volume 13, Issue 51, 14 September 2026.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Brain‐derived plasma p‐tau217 shows enhanced dynamic range for Alzheimer's disease neuropathological change

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Plasma phosphorylated tau (p‐tau), particularly p‐tau217, is a highly specific biomarker of Alzheimer's disease (AD) pathology. However, plasma p‐tau217 can be elevated in rare non‐AD conditions. Brain‐derived (BD) p‐tau217 may reduce these off‐target effects, but its performance against neuropathology has not been evaluated ...
Marisa N. Denkinger, Wagner S. Brum, Antoine Leuzy, Alpana Singh, Taina M. Marques, Valentina Ghisays, Hillary Protas, Yi Su, Ali Atri, Thomas G. Beach, Geidy E. Serrano, Kinal Bhatt, Corey M. Carlson, Katharine Hoffmann, Eric M. Reiman, Nicholas J. Ashton   +15 more
wiley   +1 more source

Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia‐related ...
Rachel K. Morgan, Evelyn K. Matei, Junru Pan, Tomoko Ishikawa, Katelyn M. Polemi, Ingrid Bergin, Sean P. Ferris, Hao Wang, Dana C. Dolinoy, Kelly M. Bakulski, Justin A. Colacino   +10 more
wiley   +1 more source

Retinal microvascular changes are related to indicators of glymphatic dysfunction and small vessel disease in frontotemporal dementia

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Retinal vascular alterations have been associated with cerebral small vessel disease (SVD) in frontotemporal dementia (FTD), but their relationship with magnetic resonance imaging (MRI)‐derived glymphatic‐related diffusion markers remains unclear.
William Robert Kwapong, Yufei Chen, Xu Chen, Jiahui Hou, Hua Lu, Yuxuan Xu, Qianqian He, Yuan Gao, Ruoyu Jiao, Liyong Wu, Xuxiang Zhang, Min Chu   +11 more
wiley   +1 more source

Mechanistic Pathways of Wound Healing: From Hemostasis to Scar‐Free Regeneration

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Wound healing is the critical process regulated through a harmonious coordination of cellular, molecular, pathological, and systemic communications. Normally, healing occurs in four overlapping phases, which are modified and controlled by various growth factor interactions and signaling pathways.
Devadass Jessy Mercy, Koyeli Girigoswami, Agnishwar Girigoswami   +2 more
wiley   +1 more source

P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
P7C3 activates NAMPT, the rate‐limiting enzyme in the NAD+ salvage pathway, elevating NAD+ levels in neurons. This engages SIRT1‐dependent nuclear signaling and SIRT3‐dependent mitochondrial regulation, enhancing mitochondrial quality control, reducing oxidative stress, and promoting neuronal survival.
Yajing Chen, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Zengyan Zhu, Mei Wang, Chao Gu   +7 more
wiley   +1 more source