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Abstract This chapter presents the case of a 61-year-old man with painful, asymmetric, sensory-predominant polyneuropathy; clinicians ultimately diagnose AL amyloid neuropathy through nerve biopsy. It traces the historical and molecular understanding of amyloidosis, emphasizing its heterogeneity and classifying major subtypes—AA, AL ...
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Primary Systemic Amyloid Neuropathy
2010Primary systemic amyloidosis (PSA) is a plasma cell dyscrasia. Organ damage is caused by deposition of amyloid, derived from monoclonal light chains, in tissues including nerves. PSA damages tissues and leads to combinations of neuropathy and renal, cardiac, and liver failure.
Harman P. S. Bajwa, John J. Kelly
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Amyloid neuropathy mimicking chronic inflammatory demyelinating polyneuropathy
Muscle & Nerve, 2011AbstractIntroduction: Amyloid neuropathy is a rare peripheral neuropathy that classically presents as a progressive sensory neuropathy with prominent autonomic involvement. Methods: We describe 5 patients with amyloid neuropathy (familial amyloid polyneuropathy or acquired amyloidosis) who were initially mistaken to have chronic inflammatory ...
Stephane, Mathis +4 more
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Rinsho shinkeigaku = Clinical neurology, 1991
Primary amyloidosis and myeloma associated amyloidosis causes neuropathy in 10% of the cases, and hemodialysis associated amyloidosis causes carpal tunnel syndrome. However, most severe amyloid neuropathy is observed in familial amyloidotic polyneuropathy (FAP).
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Primary amyloidosis and myeloma associated amyloidosis causes neuropathy in 10% of the cases, and hemodialysis associated amyloidosis causes carpal tunnel syndrome. However, most severe amyloid neuropathy is observed in familial amyloidotic polyneuropathy (FAP).
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[Familial amyloid neuropathies].
Revue neurologique, 1994Recent advances in molecular biology have given improved knowledge of familial amyloidotic polyneuropathies (FAP). FAP, originally described in Portuguese patients have been observed in many countries. These neuropathies are characterized by a sensory motor deficit beginning in the lower limbs and associated with autonomic nervous system involvement ...
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Immunohistochemistry of amyloid-related neuropathies.
Clinical neuropathology, 1992Studying eight sural nerve biopsy specimens of a biopsied trigeminal ganglions and peripheral nerves from eight autopsies, some of them retrieved 30 years ago, with a panel of antibodies against several types of amyloid revealed the presence of AF, AL of the lambda type, AA and ASs in peripheral nerve specimens while AB, AE, ASc, ASb, ACc, APrP could ...
U, Horn +6 more
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The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
Nature Reviews Drug Discovery, 2022Eric Karran, Bart De Strooper
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Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future
Signal Transduction and Targeted Therapy, 2023Weihong Song
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