Results 81 to 90 of about 145,378 (214)
The Role Of Serum Amyloid A In Inflammatory Disease - Proinflammatory Mediator Or Inert Biomarker? [PDF]
, 2010 : Neutrophils are phagocytes of the innate immune system with prominent roles in host defense and are also believed to be important in autoimmune diseases such as rheumatoid arthritis (RA) by accumulating in inflamed joints and contribute to tissues ...
Björkman, Lena
core +1 more source
Brain DisordersMagnolol (MG) is a lignan compound isolated from Magnolia officinalis, renowned for its significant neuroprotective properties include the reduction of amyloid-beta toxicity and the inhibition of apoptotic pathways in neuronal cells.
Nasrin Sultana +6 more
doaj +1 more source
POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management
American Journal of Hematology, Volume 101, Issue 10, Page 2632-2651, October 2026.ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley +1 more source
Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels [PDF]
, 2013 The objective of this study was to investigate the effects of modulating brain amyloid-b (Ab) levels at different stages of amyloid pathology on synaptic function, inflammatory cell changes and hippocampal neurogenesis, i.e.
Nordberg, A, +29 more
core +2 more sources
The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli +3 more
wiley +1 more source
Advanced Science, Volume 13, Issue 51, 14 September 2026.CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas +13 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract INTRODUCTION Plasma phosphorylated tau (p‐tau), particularly p‐tau217, is a highly specific biomarker of Alzheimer's disease (AD) pathology. However, plasma p‐tau217 can be elevated in rare non‐AD conditions. Brain‐derived (BD) p‐tau217 may reduce these off‐target effects, but its performance against neuropathology has not been evaluated ...
Marisa N. Denkinger +15 more
wiley +1 more source
Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia‐related ...
Rachel K. Morgan +10 more
wiley +1 more source
P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.P7C3 activates NAMPT, the rate‐limiting enzyme in the NAD+ salvage pathway, elevating NAD+ levels in neurons. This engages SIRT1‐dependent nuclear signaling and SIRT3‐dependent mitochondrial regulation, enhancing mitochondrial quality control, reducing oxidative stress, and promoting neuronal survival.
Yajing Chen +7 more
wiley +1 more source
Dementia Risk After Glaucoma Surgery and Medical Therapy: A Multicentre Real‐World Cohort Study
International Journal of Geriatric Psychiatry, Volume 41, Issue 9, September 2026.ABSTRACT Background and Purpose Glaucoma, a neurodegenerative optic neuropathy and leading cause of irreversible vision loss, shares vascular and neurodegenerative mechanisms with dementia. The 2024 Lancet Commission newly identified visual impairment as a modifiable dementia risk factor.
Lee‐Yuan Lin +7 more
wiley +1 more source