Results 61 to 70 of about 145,378 (214)

Association of Cerebral Amyloid-beta Aggregation With Cognitive Functioning in Persons Without Dementia [PDF]

, 2018
Importance: Cerebral amyloid-beta aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the ...
Fagan, A.M., Madsen, K., Alcolea, D., Nordberg, A., Spiru, L., Waldemar, G., Alexander, M., Scheltens, P., Rodríguez-Rodríguez, E., Zboch, M., Drzezga, A., Leon, M., Freund-Levi, Y., Herukka, S.K., Sarazin, M., Hellwig, S., Kohler, S., Chetelat, G., Aalten, P., Ivanoiu, A., Johannsen, P., Teunissen, C.E., Forster, S., Novak, G.P., Sanchez-Juan, P., Blennow, K., Verhey, F.R.J., van Buchem, M.A., Chipi, E., Gkatzima, O., Klunk, W.E., Meulenbroek, O., Mroczko, B., Almdahl, I.S., Fladby, T., Stomrud, E., Møllergård, H.M., Struyfs, H., van Waalwijk van Doorn, LJC, Camus, V., Lleo, A., Frederiksen, K.S., van der Flier, W.M., Baldeiras, I., Hildebrandt, H., Froelich, L., Chen, K., Koglin, N., Lisetti, V., Rowe, C.C., Gordon, M.F., Kornhuber, J., Mollergard, H.M., Cavedo, E., Vos, SJB, Newberg, A., Wolk, D.A., Aarsland, D., Hampel, H., Roe, C.M., Vandenberghe, R., Parnetti, L., Peters, O., Verhey, FRJ, Verbeek, M.M., Tijms, B.M., Mintun, M.A., Kramberger, M.G., Rot, U., Zetterberg, H., Villemagne, V.L., Mattsson, N., Morris, J.C., Soininen, H., Laere, K. Van, Brooks, D.J., Ossenkoppele, R., de Mendonça, A., Wallin, Å.K., Grimmer, T., Landau, S.M., Sabri, O., Na, D.L., Rinne, J.O., Rüther, E., Fleisher, A.S., Kapaki, E., Buchem, M.A. van, Meyer, P.T., Hausner, L., Schröder, J., Rabinovici, G.D., Berckel, B.N. van, Frisoni, G.B., Ramakers, I., et al., Ramakers, IHGB, Rami, L., Gabryelewicz, T., Mendonca, A. de, Fortea, J., Flier, W.M. van der, Wallin, A., Jansen, W.J., Visser, P.J., Maier, W., Hansson, O., Cohen, A.D., Lee, D.Y., van Laere, K., van Berckel, BNM, Wiltfang, J., Paraskevas, G.P., Mok, V., Arnold, S.E., Marcusson, J., Tsolaki, M., Oliveira, C. de, Barthel, H., Santana, I., Klimkowicz-Mrowiec, A., Molinuevo, J.L., Engelborghs, S., Resende de Oliveira, C., Nordlund, A., Perera, G., de Leon, M., Popp, J., Jagust, W.J., Seo, S.W.   +128 more
core   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model

Cells, 2019
Neuroglobin is a heme protein of which increased levels provide neuroprotection against amyloid proteinopathy and hemorrhagic damage. These cellular stressors involve the promotion of ferroptosis—an iron-dependent, lipid peroxide-accreting form of ...
Zoë P. Van Acker, Geert A. Van Raemdonck, Emilie Logie, Sara I. Van Acker, Geert Baggerman, Wim Vanden Berghe, Peter Ponsaerts, Sylvia Dewilde   +7 more
doaj   +1 more source

Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization

, 2013
Inflammatory processes are important in the pathogenesis of Alzheimer's disease and in response to amyloid-β immunotherapy. We investigated the expression of multiple inflammatory markers in the brains of 28 non-immunized patients with Alzheimer's ...
Cheaveau, M., Morgan, William, Cheaveau, Matthew, Boche, Delphine, Bharambe, V., Holmes, C., Love, S., Nicoll, James A R, Harris, Scott, Bharambe, Viraj, Neal, James W, Love, Seth, Nicoll, J.A.R., Zotova, E., Boche, D., Morgan, W., Neal, J.W., Holmes, Clive, Zotova, Elina   +18 more
core   +1 more source

Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH. [PDF]

, 2002
BACKGROUND: One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Abeta, in the brain. Abeta arises from cleavage of the Amyloid Precursor protein by beta and gamma secretases, which present attractive candidates
Brian Austen, Liu, C, Austen, B, Chibuu Liu, Sidera, C, Christina Sidera   +5 more
core   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Breast cancer and amyloid bodies: is there a role for amyloidosis in cancer-cell dormancy?

Breast Cancer: Targets and Therapy, 2017
Gerald J Mizejewski Wadsworth Center, New York State Department of Health, Albany, NY, USA Abstract: Breast cancer and Alzheimer’s disease (AD) are major causes of death in older women.
Mizejewski GJ
doaj  

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

40 years of CEPARM: transforming amyloidosis related to transthyretin from neglect to recognition

Arquivos de Neuro-Psiquiatria
Variant transthyretin amyloidosis with polyneuropathy (ATTRv-PN) and cardiomyopathy (ATTRv-CM), formerly known as familial amyloidotic polyneuropathy (FAP), is a severe, progressive disorder caused by mutations in the transthyretin (TTR) gene ...
Marcia Waddington Cruz, Marleide da Mota Gomes   +1 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source