Results 241 to 250 of about 36,206 (272)

γ‐Secretase‐dependent cleavage of amyloid precursor protein regulates osteoblast behavior

The FASEB Journal, 2009
ABSTRACT γ‐Secretase cleaves amyloid precursor protein (APP) to generate amyloid‐β (Aβ) peptides, which aggregate in the brain in Alzheimer's disease (AD). γ‐Secretase also cleaves molecules that regulate osteoblast activity, such as Notch and ephrinB2. However, the role of APP in bone is unknown.
Curtis, Neil, Fagan, Michael J., McLeod, Jane, Lewis, Huw D., Good, Mark A., Genever, Paul G.   +5 more
openaire   +3 more sources

Role of Amyloid Precursor Protein, Amyloid-β and γ-Secretase in Cholesterol Maintenance

Neurodegenerative Diseases, 2006
Lipids play an important part as risk factors for Alzheimer’s disease. This article summarizes the current understanding of the molecular mechanism by which amyloid-β (Aβ) peptides regulate cholesterol and sphingomyelin metabolism, and how in return cholesterol and sphingomyelin regulate Aβ peptide production.
openaire   +2 more sources

Role of presenilin in γ-secretase cleavage of amyloid precursor protein

Experimental Gerontology, 2000
Cerebral accumulation of the amyloid beta-protein (Abeta) is an early and invariant event in the pathogenesis of Alzheimer's disease (AD). Mutations in the presenilin (PS) 1 and 2 genes that increase production of the highly amyloidogenic Abeta(42) are the most common cause of familial AD.
openaire   +2 more sources

Alzheimer's disease amyloid precursor protein (ApPP): proteolytic processing, secretases and βA4 amyloid production

Amyloid, 1994
The major component of Alzheimer's disease amyloid is the 4 kDa peptide βA4 which is produced from an integral membrane protein (amyloid beta precursor protein, AβPP) by proteolytic processing. Cleavage of the βA4 domain from the precursor protein is part of a complex process which results in the release of AβPP from the membrane.
Genevieve Evin, Konrad Beyreuther, Colin L. Masters   +2 more
openaire   +1 more source

Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and Presenilin

Experimental Brain Research, 2011
Alzheimer's disease causing mutations in the amyloid precursor protein (APP) or in the Presenilin 1 (PS1) or Presenilin 2 (PS2) genes increase the production of amyloid peptides (Aβ) that precipitate in amyloid plaques. Since amyloid plaques are also a prominent feature of sporadic Alzheimer's disease (AD), abnormal proteolysis of APP and the ...
Johannes, Prox, Andrea, Rittger, Paul, Saftig   +2 more
openaire   +2 more sources

ASP1 (BACE2) Cleaves the Amyloid Precursor Protein at the β-Secretase Site

Molecular and Cellular Neuroscience, 2000
Sequential proteolytic processing of the Amyloid Precursor Protein (APP) by beta- and gamma-secretases generates the 4-kDa amyloid (A beta) peptide, a key component of the amyloid plaques seen in Alzheimer's disease (AD). We and others have recently reported the identification and characterisation of an aspartic proteinase, Asp2 (BACE), as beta ...
I, Hussain, D J, Powell, D R, Howlett, G A, Chapman, L, Gilmour, P R, Murdock, D G, Tew, T D, Meek, C, Chapman, K, Schneider, S J, Ratcliffe, D, Tattersall, T T, Testa, C, Southan, D M, Ryan, D L, Simmons, F S, Walsh, C, Dingwall, G, Christie   +18 more
openaire   +2 more sources

Using an Amyloid Precursor Protein (APP) Reporter to Characterize α-Secretase

2003
Human genetic studies suggest decreasing amyloid peptide (Aβ) levels in the brain could alter the course of Alzheimer's disease (AD) (1 -4). Proteolytic cleavages govern the level of Aβ generated from the amyloid precursor protein (APP). β- and γ-cleavages at the amino and carboxyl termini of Aβ produce amyloidogenic peptides; in contrast, α-cleavage ...
openaire   +2 more sources

Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases

Amyloid, 1998
Proteolytic cleavage of the amyloid precursor protein (A beta PP) results in the generation of the amyloidogenic fragment known as amyloid beta peptide (A beta). Deposition of A beta in the brain parenchyma and cerebrovasculature is a feature of Alzheimer's disease (AD). To date, the process whereby A beta is generated and deposited remains unclear. We
E R, Simons, D C, Marshall, H J, Long, K, Otto, A, Billingslea, H, Tibbles, J, Wells, P, Eisenhauer, R E, Fine, D H, Cribbs, T A, Davies, C R, Abraham   +11 more
openaire   +2 more sources

Angiotensin-converting enzyme and the amyloid precursor protein secretases

Biochemical Society Transactions, 1999
N M, Hooper, S, Parvathy, E H, Karran, A J, Turner   +3 more
openaire   +2 more sources

Molecular characterisation of the alzheimer's amyloid precursor protein secretases

Biochemical Society Transactions, 1998
S L, Houldsworth, A J, Trew, N M, Hooper, A J, Turner   +3 more
openaire   +2 more sources