Results 261 to 270 of about 36,206 (272)

A study of b-secretase cleaved Alzheimer amyloid precursor protein

2002
Alzheimer's disease (AD) is characterized by the degeneration and loss of neurons, intracellular neurofibrillary tangles and the accumulation of extracellular senile plaques consisting mainly of beta-amyloid (A-beta). A-beta is generated from the amyloid precursor protein (APP) through sequential cleavage by proteases P- and gamma-secretase ...
openaire   +1 more source

Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro

Neuroscience Letters, 2009
Kang Le, Liang Tao, Shu Tang
exaly  

Levels of α- and β-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients

Neuroscience Letters, 2000
Eirkiur Benedikz
exaly  

Characterization of “secretase”, Alzheimer amyloid protein precursor secreting enzyme

Neurobiology of Aging, 1992
openaire   +1 more source

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Nature, 1999
Michael S Wolfe, Weiming Xia, W Taylor Kimberly   +2 more
exaly  

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Nature, 1998
Bart De Strooper, Paul Saftig, Hugo Vanderstichele   +2 more
exaly  

Decreased α-secretase-cleaved amyloid precursor protein as a diagnostic marker for Alzheimer's diseas

Nature Medicine, 1995
Lars-Olof Wahlund
exaly  

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

Neurobiology of Disease, 2013
Huanhuan Wang, Peer-Hendrik Kuhn, Elisabeth Kremmer   +2 more
exaly  

The amyloid precursor protein (APP)-cytoplasmic fragment generated by γ-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

Journal of Neurochemistry, 2001
Wim Annaert, Bart De Strooper, Katleen Craessaerts   +2 more
exaly  

Oxidative stress activates a positive feedback between the γ‐ and β‐secretase cleavages of the β‐amyloid precursor protein

Journal of Neurochemistry, 2008
MICHELA GUGLIELMOTTO, Manuela Aragno, Riccardo Autelli   +2 more
exaly