Results 51 to 60 of about 200,281 (336)

Expert Consensus Recommendations for the Suspicion and Diagnosis of Transthyretin Cardiac Amyloidosis.

Circulation: Heart Failure, 2019
Cardiomyopathy is a manifestation of transthyretin amyloidosis (ATTR), which is an underrecognized systemic disease whereby the transthyretin protein misfolds to form fibrils that deposit in various tissues and organs.
M. Maurer, S. Bokhari, T. Damy, S. Dorbala, B. Drachman, M. Fontana, M. Grogan, A. Kristen, I. Lousada, J. Nativi-Nicolau, Candida Cristina Quarta, C. Rapezzi, F. Ruberg, R. Witteles, G. Merlini   +14 more
semanticscholar   +1 more source

Diagnosis and treatment of cardiac amyloidosis: position statement of the German Cardiac Society (DGK)

Clinical Research in Cardiology, 2021
Systemic forms of amyloidosis affecting the heart are mostly light-chain (AL) and transthyretin (ATTR) amyloidoses. The latter is caused by deposition of misfolded transthyretin, either in wild-type (ATTRwt) or mutant (ATTRv) conformation.
Yilmaz, Bauersachs, Bengel, Büchel, Kindermann, Klingel, Knebel, Meder, Morbach, Nagel, Schulze ‐ Bahr, Siepen, Frey   +12 more
semanticscholar   +1 more source

A retrospective study of isatuximab-pomalidomide-dexamethasone in relapsed/refractory systemic AL amyloidosis

Haematologica
Not available.
Sargam Rachit Vohra, Sriram Ravichandran, Darren Foard, Ana Martinez-Naharro, Lucia Venneri, Marianna Fontana, Carol J. Whelan, Philip N. Hawkins, Julian Gillmore, Helen J. Lachmann, Shameem Mahmood, Ashutosh D. Wechalekar   +11 more
doaj   +1 more source

Self‐Assembly, Rearrangement, and Disassembly of {Cr6} Horseshoe Oligomers

Angewandte Chemie, EarlyView.
Using a combination of ion mobility mass spectrometry (IM‐MS), tandem mass spectrometry (MS2), and low‐temperature scanning tunneling microscopy (STM), we elucidate the self‐assembly, rearrangement, and disassembly processes of polymetallic {Cr6}x (x = 1 – 5) horseshoe oligomers.
Niklas Geue, Dhaneesh Kumar, Jimin Ham, Shengpeng Huang, Grigore A. Timco, Neil A. Burton, Richard E. P. Winpenny, Kelvin Anggara, Perdita E. Barran   +8 more
wiley   +2 more sources

Dissecting the Molecular Features of Systemic Light Chain (AL) Amyloidosis: Contributions from Proteomics

Medicina, 2021
Amyloidoses are characterized by aggregation of proteins into highly ordered amyloid fibrils, which deposit in the extracellular space of tissues, leading to organ dysfunction.
Paola Rognoni, Giulia Mazzini, Serena Caminito, Giovanni Palladini, Francesca Lavatelli   +4 more
doaj   +1 more source

Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice [PDF]

, 2009
The SpAs are a group of overlapping, chronic, inflammatory rheumatic diseases including AS, a chronic inflammatory disease primarily affecting the SI joints.
Elewaut, Dirk, Matucci-Cerinic, Marco
core   +1 more source

Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy

Journal of Neurology, 2020
Amyloid transthyretin (ATTR) amyloidosis with polyneuropathy (PN) is a progressive, debilitating, systemic disease wherein transthyretin protein misfolds to form amyloid, which is deposited in the endoneurium. ATTR amyloidosis with PN is the most serious
D. Adams, Y. Ando, J. Beirão, T. Coelho, M. Gertz, J. Gillmore, P. Hawkins, I. Lousada, O. Suhr, G. Merlini   +9 more
semanticscholar   +1 more source

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

Cardiac transplantation in transthyretin amyloid cardiomyopathy: Outcomes from three decades of tertiary center experience

Frontiers in Cardiovascular Medicine, 2023
AimsTransthyretin cardiac amyloidosis (ATTR-CM) is a progressive and fatal cardiomyopathy. Treatment options in patients with advanced ATTR-CM are limited to cardiac transplantation (CT).
Yousuf Razvi, Aldostefano Porcari, Aldostefano Porcari, Concetta Di Nora, Rishi K. Patel, Adam Ioannou, Muhammad U. Rauf, Ambra Masi, Steven Law, Liza Chacko, Tamer Rezk, Sriram Ravichandran, Janet Gilbertson, Dorota Rowczenio, Iona J. Blakeney, Nandita Kaza, David F. Hutt, Helen Lachmann, Ashutosh Wechalekar, William Moody, Sern Lim, Colin Chue, Carol Whelan, Lucia Venneri, Ana Martinez-Naharro, Marco Merlo, Gianfranco Sinagra, Ugolino Livi, Philip Hawkins, Marianna Fontana, Julian D. Gillmore   +30 more
doaj   +1 more source

Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis

New England Journal of Medicine, 2018
BACKGROUND Hereditary transthyretin amyloidosis is caused by pathogenic single‐nucleotide variants in the gene encoding transthyretin (TTR) that induce transthyretin misfolding and systemic deposition of amyloid. Progressive amyloid accumulation leads to
M. Benson, M. Waddington-Cruz, J. Berk, M. Polydefkis, P. Dyck, Annabel K. Wang, V. Planté-Bordeneuve, F. Barroso, G. Merlini, L. Obici, M. Scheinberg, T. Brannagan, W. Litchy, C. Whelan, B. Drachman, D. Adams, S. Heitner, I. Conceição, H. Schmidt, G. Vita, J. Campistol, J. Gámez, P. Gorevic, E. Gane, A. Shah, S. Solomon, B. Monia, S. Hughes, J. Kwoh, B. McEvoy, Shiangtung W. Jung, B. Baker, E. Ackermann, M. Gertz, T. Coelho   +34 more
semanticscholar   +1 more source