Results 91 to 100 of about 995,258 (307)

Associations of cachexia and frailty with amyotrophic lateral sclerosis

Scientific Reports
In the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in ...
Tracy L. Peters, Weihong Qiu, Haomin Yang, Wuqing Huang, Yizhen Hu, Zhangyu Zou, Weimin Ye   +6 more
doaj   +1 more source

Mesenchymal stem cell–derived extracellular vesicle treatment of induced pluripotent stem cell–derived motor neurons with different amyotrophic lateral sclerosis genetic backgrounds

Neural Regeneration Research
Motor neurons derived from induced human pluripotent stem cells offer a powerful model to study motor neuron diseases, such as amyotrophic lateral sclerosis. While widely used, our knowledge of the proteomic changes in these models is rather rudimentary.
Suzy Varderidou-Minasian, Channa E. Jakobs, Svetlana Pasteuning-Vuhman, Lars Gal, Annabel Timmers, Maarten Altelaar, Magdalena J. Lorenowicz, R. Jeroen Pasterkamp   +7 more
doaj   +1 more source

Leukocyte-derived microparticles and scanning electron microscopic structures in two fractions of fresh cerebrospinal fluid in amyotrophic lateral sclerosis: a case report

Journal of Medical Case Reports, 2012
Introduction Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder characterized by degeneration of motoneuron cells in anterior spinal horns. There is a need for early and accurate diagnosis with this condition.
Zachau Anne C, Landén Mikael, Mobarrez Fariborz, Nybom Rolf, Wallén Håkan, Wetterberg Lennart   +5 more
doaj   +1 more source

Amyotrophic Lateral Sclerosis and Urbanization in the Health district of Ferrara, Italy in 1964-1998

, 2008
Amyotrophic Lateral Sclerosis and Urbanization in the Health district of Ferrara, Italy in 1964 ...
GOVONI, Vittorio
core  

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

What causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved]

F1000Research, 2017
Amyotrophic lateral sclerosis is a neurodegenerative disease predominantly affecting upper and lower motor neurons, resulting in progressive paralysis and death from respiratory failure within 2 to 3 years. The peak age of onset is 55 to 70 years, with a
Sarah Martin, Ahmad Al Khleifat, Ammar Al-Chalabi   +2 more
doaj   +1 more source

Amyotrophic lateral sclerosis – a motor neuron disease. Case report [PDF]

, 2015
Amyotrophic lateral sclerosis, also known as Charcot’s disease and motor neuron disease, is a progressive neurodegenerative disease that causes muscle weakness, paralysis, and ultimately, respiratory failure.
Maja Rubinowicz-Zasada, Jarosław Pasek, Orczyk, Aneta, Pasek, Jarosław, Rubinowicz-Zasada, Maja, Marek Orczyk, Aneta Orczyk, Orczyk, Marek   +7 more
core   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Dietary BMAA exposure in an amyotrophic lateral sclerosis cluster from southern France.

PLoS ONE, 2013
BackgroundDietary exposure to the cyanotoxin BMAA is suspected to be the cause of amyotrophic lateral sclerosis in the Western Pacific Islands. In Europe and North America, this toxin has been identified in the marine environment of amyotrophic lateral ...
Estelle Masseret, Sandra Banack, Farid Boumédiène, Eric Abadie, Luc Brient, Fabrice Pernet, Raoul Juntas-Morales, Nicolas Pageot, James Metcalf, Paul Cox, William Camu, French Network on ALS Clusters Detection and Investigation   +11 more
doaj   +1 more source

Transcriptomics in amyotrophic lateral sclerosis

Frontiers in Bioscience, 2018
Amyotrophic lateral sclerosis (ALS) is an adult-onset, incurable neurodegenerative disease characterized by the selective death of upper and lowers motor neurons in the spinal cord, brainstem and motor cortex, which ultimately leads to paralysis and death within 2-3 years of onset.
Marios G, Krokidis, Panagiotis, Vlamos
openaire   +2 more sources