Results 91 to 100 of about 167,403 (289)

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage [PDF]

, 2013
Amyotrophic lateral sclerosis (ALS) is associated with progressive degeneration of motor neurons. Several of the genes associated with this disease encode proteins involved in RNA processing, including fused-in-sarcoma/translocated-in-sarcoma (FUS/TLS ...
Adamson, Ahel, Amy Rotheray, Amé, Beli, Bertolotti, Chou, Da Cruz, Das, Dormann, Dormann, Duncan A. Q. Moore, El-Khamisy, Fernando Gómez-Herreros, Gabrielle J. Grundy, Gagné, Gardiner, Gitler, Hallier, Hanson, Hicks, Hoell, Johansson, Keith W Caldecott, Kino, Kleiman, Kleiman, Kleiman, Krietsch, Kuroda, Kwiatkowski, Lagier-Tourenne, Lagier-Tourenne, Lehtiö, Mackenzie, Majid Hafezparast, Malanga, Mastrocola, Masutani, Polo, Polymenidou, Rulten, Rulten, Ryan L. Green, Schwartz, Shieh, Stuart L. Rulten, Tan, Tan, Turner, Vance, Wang, Yang, Yang   +53 more
core   +1 more source

Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila

Advanced Science, EarlyView.
Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu, Xuedi Zhang, Ying Zhou, Jie Zheng, Angyang Sun, Kailong Zhuang, Weiwei Bao, Guanjun Gao   +7 more
wiley   +1 more source

Associations of cachexia and frailty with amyotrophic lateral sclerosis

Scientific Reports
In the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in ...
Tracy L. Peters, Weihong Qiu, Haomin Yang, Wuqing Huang, Yizhen Hu, Zhangyu Zou, Weimin Ye   +6 more
doaj   +1 more source

What causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved]

F1000Research, 2017
Amyotrophic lateral sclerosis is a neurodegenerative disease predominantly affecting upper and lower motor neurons, resulting in progressive paralysis and death from respiratory failure within 2 to 3 years. The peak age of onset is 55 to 70 years, with a
Sarah Martin, Ahmad Al Khleifat, Ammar Al-Chalabi   +2 more
doaj   +1 more source

Early exposure to environmental toxin contributes to neuronal vulnerability and axonal pathology in a model of familial ALS [PDF]

, 2011
Adult onset amyotrophic lateral sclerosis (ALS) arises due to progressive and irreversible functional deficits to the central nervous system, specifically the loss of motor neurons.
Christopher A. Shaw, Grace Lee
core   +1 more source

Familial Amyotrophic Lateral Sclerosis [PDF]

Neurologic Clinics, 2015
Genes linked to amyotrophic lateral sclerosis (ALS) susceptibility are being identified at an increasing rate owing to advances in molecular genetic technology. Genetic mechanisms in ALS pathogenesis seem to exert major effects in about 10% of patients, but genetic factors at some level may be important components of disease risk in most patients with ...
openaire   +2 more sources

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Difficulties in diagnosing amyotrophic lateral sclerosis in a HIV-Positive Patient

Журнал инфектологии, 2018
We described a case of amyotrophic lateral sclerosis (ALS) with comorbid HIV infection. The diagnosis was confirmed by genetic tests. The difficulty of the differential diagnosis between amyotrophic lateral sclerosis and HIV-associated ALS syndrome is ...
T. M. Alekseeva, N. V. Skripchenko, S. V. Lobzin, V. S. Demeshonok, E. A. Yurkina, V. D. Nazarov, S. V. Lapin   +6 more
doaj   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Exploring platelet metabolomics and fatty acid profiles for ALS prognosis and diagnosis

Scientific Reports
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with heterogeneous clinical progression, reflecting distinct underlying pathological mechanisms.
Pascual Torres, Irene Pradas, Anna Fernàndez-Bernal, Mònica Povedano, Raul Dominguez, Mariona Jové, Cristina Gonzalez-Mingot, Victòria Ayala, Isidre Ferrer, Reinald Pamplona, Manuel Portero-Otin   +10 more
doaj   +1 more source