Results 101 to 110 of about 995,258 (307)

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

A Case of Amiotrophic Lateral Sclerosis Presenting with Daytime Excessive Sleepiness

Türk Uyku Tıbbı Dergisi, 2019
Amyotrophic lateral sclerosis is a neurodegenerative disease with progressive motor neuron degeneration in primary motor cortex, corticospinal pathways, brain stem and spinal cord.
Turgay Demir, Kezban Aslan, Mehmet Balal, Şebnem Bıçakcı   +3 more
doaj   +1 more source

Difficulties in diagnosing amyotrophic lateral sclerosis in a HIV-Positive Patient

Журнал инфектологии, 2018
We described a case of amyotrophic lateral sclerosis (ALS) with comorbid HIV infection. The diagnosis was confirmed by genetic tests. The difficulty of the differential diagnosis between amyotrophic lateral sclerosis and HIV-associated ALS syndrome is ...
T. M. Alekseeva, N. V. Skripchenko, S. V. Lobzin, V. S. Demeshonok, E. A. Yurkina, V. D. Nazarov, S. V. Lapin   +6 more
doaj   +1 more source

Defining pre-symptomatic amyotrophic lateral sclerosis

, 2019
Successful treatment of neurodegenerative disease may hinge on early therapeutic intervention. This requires an understanding of early/pre-symptomatic disease, a need that is underscored by advances in antisense oligonucleotide, and viral-vector-based ...
Turner, Martin R, Benatar, Michael, Wuu, Joanne   +2 more
core   +1 more source

The reunification of amyotrophic lateral sclerosis [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2018
Historically characterised as a neuromuscular disease involving progressive loss of both central and peripheral motor neurons, amyotrophic lateral sclerosis (ALS) now sits among the cerebral neurodegenerative syndromes, involving clinical, pathological and genetic overlap with frontotemporal dementia (FTD).
openaire   +2 more sources

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Exploring platelet metabolomics and fatty acid profiles for ALS prognosis and diagnosis

Scientific Reports
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with heterogeneous clinical progression, reflecting distinct underlying pathological mechanisms.
Pascual Torres, Irene Pradas, Anna Fernàndez-Bernal, Mònica Povedano, Raul Dominguez, Mariona Jové, Cristina Gonzalez-Mingot, Victòria Ayala, Isidre Ferrer, Reinald Pamplona, Manuel Portero-Otin   +10 more
doaj   +1 more source

Preserving Motor Features by Alternative Re‐Referencing to Remove Heart Artifact on the Stentrode

Advanced Science, EarlyView.
Endovascular brain‐computer interfaces record neural activity from within cerebrovasculature, at the expense of electrocardiogram contamination. Band‐limited independent component analysis separates this heart‐based artifact from task‐relevant neural activity in each frequency band, enabling the reconstruction of cleaner neural recordings without the ...
Ariel K. Feldman, Kriti Kacker, Rahyun Yun, Nikole Chetty, James Bennett, Peter E. Yoo, Raul G. Nogueira, Jennifer L. Collinger, Nicholas L. Opie, Thomas J. Oxley, David F. Putrino, Douglas J. Weber   +11 more
wiley   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Review of Prognostic Testing for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Neurologijos seminarai
Frontotemporal dementia and amyotrophic lateral sclerosis are neurodegenerative diseases with distinc clinical presentation, but interconnected with each other.
Donata Pakeltytė, Birutė Burnytė
doaj   +1 more source