Results 281 to 290 of about 235,642 (386)

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Nature Genetics, 2016
W. van Rheenen, A. Shatunov, Annelot M. Dekker, R. Mclaughlin, F. Diekstra, S. Pulit, Rick A. A. van der Spek, U. Võsa, S. de Jong, M. Robinson, Jian Yang, I. Fogh, P. T. V. van Doormaal, Gijs H. P. Tazelaar, M. Koppers, A. Blokhuis, W. Sproviero, Ashley R. Jones, K. Kenna, K. van Eijk, O. Harschnitz, Raymond D. Schellevis, W. Brands, J. Medić, A. Menelaou, A. Vajda, N. Ticozzi, Kuang Lin, B. Rogelj, Katarina Vrabec, M. Ravnik-Glavač, B. Koritnik, J. Zidar, L. Leonardis, L. D. Grošelj, S. Millecamps, F. Salachas, V. Meininger, M. de Carvalho, S. Pinto, J. Mora, R. Rojas‐García, M. Polak, S. Chandran, Shuna Colville, R. Swingler, K. Morrison, P. Shaw, J. Hardy, R. Orrell, A. Pittman, K. Sidle, P. Fratta, A. Malaspina, S. Topp, S. Petri, S. Abdulla, C. Drepper, M. Sendtner, T. Meyer, R. Ophoff, K. Staats, M. Wiedau-Pazos, C. lomen-Hoerth, V. V. Van Deerlin, J. Trojanowski, L. Elman, L. McCluskey, A. Başak, Ceren Tunca, Hamid Hamzeiy, Y. Parman, T. Meitinger, P. Lichtner, Milena Radivojkov-Blagojević, C. Andres, Cindy Maurel, G. Bensimon, B. Landwehrmeyer, A. Brice, C. Payan, Safa Saker-Delye, A. Dürr, N. Wood, L. Tittmann, W. Lieb, A. Franke, M. Rietschel, S. Cichon, M. Nöthen, P. Amouyel, C. Tzourio, J. Dartigues, A. Uitterlinden, F. Rivadeneira, K. Estrada, A. Hofman, C. Curtis, H. Blauw, A. J. van der Kooi, M. de Visser, A. Goris, Markus Weber, C. Shaw, Bradley N. Smith, O. Pansarasa, Cristina Cereda, R. del Bo, G. Comi, S. D'alfonso, C. Bertolin, G. Soraru', L. Mazzini, V. Pensato, C. Gellera, C. Tiloca, A. Ratti, A. Calvo, C. Moglia, M. Brunetti, S. Arcuti, R. Capozzo, C. Zecca, C. Lunetta, S. Penco, N. Riva, A. Padovani, M. Filosto, B. Muller, Robbert Jan Stuit, I. Blair, Katharine Y. Zhang, E. McCann, J. Fifita, G. Nicholson, D. Rowe, R. Pamphlett, M. Kiernan, J. Grosskreutz, O. Witte, T. Ringer, T. Prell, B. Stubendorff, I. Kurth, C. Hübner, P. Leigh, F. Casale, A. Chiò, E. Beghi, E. Pupillo, R. Tortelli, G. Logroscino, J. Powell, A. Ludolph, Jochen H Weishaupt, W. Robberecht, P. van Damme, L. Franke, T. Pers, Robert H. Brown, J. Glass, J. Landers, O. Hardiman, P. Andersen, P. Corcia, P. Vourc'h, V. Silani, N. Wray, P. Visscher, P. D. de Bakker, M. V. van Es, R. Pasterkamp, C. Lewis, G. Breen, A. Al-Chalabi, L. H. van den Berg, J. Veldink   +176 more
semanticscholar   +1 more source

Nanoparticle‐Based Tetracycline Delivery Systems: Advancing Therapeutic Effectiveness and Tackling Antibiotic Resistance

Particle &Particle Systems Characterization, EarlyView.
This review explores improved tetracycline (TCN) delivery via polymer‐based nanocarriers to enhance solubility, stability, and targeted release. It also covers stimuli‐responsive systems, triggered by pH, enzymes, or reactive oxygen species (ROS), and co‐delivery approaches that increase therapeutic efficacy in cancer and inflammatory diseases ...
Mahsa Molaei Nasr, Mehrab Pourmadadi, Fatemeh Yazdian, Hamid Rashedi, Abbas Rahdar, M. Ali Aboudzadeh   +5 more
wiley   +1 more source

Integrating genetic testing into management of all patients with amyotrophic lateral sclerosis: a critical juncture. [PDF]

CMAJ
Breiner A, Schellenberg KL, Shoesmith C.
europepmc   +1 more source

A New Phenotype–Genotype Correlation for FIG4 and Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Iro Boura, Panayiotis Mitsias, Sofia Erimaki, Efrosini Papadaki, Cleanthe Spanaki   +4 more
wiley   +1 more source

Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell, Amin Rostami‐Hodjegan, Guy Meno‐Tetang, Donald E. Mager, Kayode Ogungbenro   +4 more
wiley   +1 more source

Hospital-treated infections and the risk and prognosis of amyotrophic lateral sclerosis: A population-based study. [PDF]

J Intern Med
Hu Y, Chourpiliadis C, Ingre C, Ahlqvist VH, Sun J, Song H, Pawitan Y, Piehl F, Fang F.   +8 more
europepmc   +1 more source

A case of amyotrophic lateral sclerosis presenting " eye-opening apraxia".

, 1996
寺川 晴彦, 阿部 和夫, 服部 憲明, 依藤 史郎, 柳原 武彦, 中村 雅一   +5 more
openalex   +2 more sources

Transforming Pediatric Rare Disease Drug Development: Enhancing Clinical Trials and Regulatory Evidence With Virtual Patients

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Drug development in pediatric rare diseases is complicated by practical and ethical constraints on clinical trial design, stemming from small, highly heterogeneous, and vulnerable patient populations. Virtual patients (VPs) created with machine‐learning (ML), mechanistically driven computational approaches, or hybrids thereof, have the ...
Fianne Sips, Marco Virgolin, Giuseppe Pasculli, Federico Reali, Alessio Paris, Annette Janus, Yann Godfrin, Daniel Röshammar, Luca Marchetti, Jane Knöchel   +9 more
wiley   +1 more source

Genetic Variants Associated With Neurodegenerative Disorders in Patients With Amyotrophic Lateral Sclerosis and Phenotypic Variability. [PDF]

Neurology
Grassano M, Koumantakis E, Palumbo FF, Brunetti M, De Marco G, Merulla I, Paolantonio C, Iazzolino B, Testa M, Manera U, Canosa A, Vasta R, Fuda G, Salamone P, Marchese G, Casale F, Gallone S, Mora G, Moglia C, Calvo A, Chiò A.   +20 more
europepmc   +1 more source

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration

Small Science, EarlyView.
Cancer and neurodegeneration share interconnected nanosized molecular pathways. Novel nanobiomedicine approaches promise targeted biomarkers and therapies. Atomic force microscopy (AFM) is invaluable to characterize nanosized biomolecular processes beyond imaging.
Carlos Marcuello, KeeSiang Lim, Giacomo Nisini, Vadim S. Pokrovsky, João Conde, Francesco Simone Ruggeri   +5 more
wiley   +1 more source