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Postgraduate Medicine, 1981
Amyotrophic lateral sclerosis, a progressive disease characterized by selective loss of upper and lower motor neurons, equals or exceeds multiple sclerosis in incidence. The clinical and pathologic features are discussed, as well as practical management strategies.
L L, Amico, J P, Antel
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Amyotrophic lateral sclerosis, a progressive disease characterized by selective loss of upper and lower motor neurons, equals or exceeds multiple sclerosis in incidence. The clinical and pathologic features are discussed, as well as practical management strategies.
L L, Amico, J P, Antel
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Amyotrophic Lateral Sclerosis Microgenomics
Physical Medicine and Rehabilitation Clinics of North America, 2005Amyotrophic lateral sclerosis (ALS) is a degenerative disease of the cen-tral nervous system (CNS) characterized by progressive weakness from de-generation of motor neurons [1]. The main clinical features of weaknessare focal onset at any region of the neuraxis, a mix of upper and lowermotor neuron dysfunction, and contiguous spread over time [2] (Fig.
John, Ravits +2 more
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Introducing Amyotrophic lateral sclerosis.
Archives italiennes de biologie, 2011Introducing ALS at present times leads to re-define the concept of motor neuron selectivity which characterizes this disorder. In fact, multiple systems including skin, liver, and bone marrow are altered in ALS patients. The motor neuron is still the focus of the disorder and the extended pathology did not modify the concept of ALS as a devastating ...
Silani V, Meininger V, FORNAI, FRANCESCO
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Juvenile amyotrophic lateral sclerosis
The Indian Journal of Pediatrics, 2006Juvenile amytrophic lateral sclerosis (JALS) is a type of motor neuron disease presenting before 25 years of age. It is characterized by a combination of upper and lower motor signs. It may be familial or sporadic. We are reporting a sporadic case of JALS with onset of symptoms at 4 years of age. Diagnostic criteria and a brief review of literature are
Anju, Aggarwal, , Shashiraj
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Familial amyotrophic lateral sclerosis
Muscle & Nerve, 2002AbstractThe increasing complexity of the pathways implicated in the pathogenesis of familial amyotrophic lateral sclerosis (ALS) has stimulated intensive research in many directions. Genetic analysis of familial ALS has yielded six loci and one disease gene (SOD1), initially suggesting a role for free radicals in the disease process, although the ...
Collette K, Hand, Guy A, Rouleau
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Ameliorating Amyotrophic Lateral Sclerosis
New England Journal of Medicine, 2010A newly implicated molecular pathway in skeletal muscle regulates the formation of the neuromuscular junction and is implicated in a mouse model of amyotrophic lateral sclerosis.
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Familial amyotrophic lateral sclerosis
1997Amyotrophic lateral sclerosis is sporadic in ninety percent of cases and familial (FALS) in ten percent. Both forms of FALS whether transmitted as an autosomal dominant (DFALS) or as an autosomal recessive (RFALS) trait is genetically heterogeneous. The locus for one form of RFALS maps to chromosome 2q33.
T, Siddique, D, Nijhawan, A, Hentati
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