Results 241 to 250 of about 995,258 (307)

Common inputs to motor units are modulated by force profile and muscle length

Experimental Physiology, EarlyView.
Abstract Groups of motor units receive common synaptic inputs from specialized networks of premotor neurons to produce movement. Here, we test whether common inputs received by motor units in the first dorsal interosseous are fixed or task‐dependent during submaximal isometric contractions.
Abdulkerim Darendeli, Oscar Soto, Eugene Tunik, Mathew Yarossi   +3 more
wiley   +1 more source

Considering prediagnostic environmental modifiers of progression in amyotrophic lateral sclerosis. [PDF]

BMJ Neurol Open
Chalitsios CV, Turner MR.
europepmc   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Integrated multi-omics identification of m6A-SNP-related diagnostic biomarkers in amyotrophic lateral sclerosis. [PDF]

Front Immunol
Wang H, Sun B, Wang S, Pan J, Du R, Pang X, Bai J, Han J, Feng J.   +8 more
europepmc   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Living with Amyotrophic Lateral Sclerosis: Exploring what matters to patients and caregivers through their experiences. [PDF]

Palliat Care Soc Pract
Zambetti E, Belli S, Mucci C, Greco A.
europepmc   +1 more source

Circulating microRNA signatures reveal core and reversible dysregulation in obesity via machine learning

The Journal of Physiology, EarlyView.
Abstract figure legend Machine learning analysis of circulating microRNA (miRNA) profiles identified a minimal set of biomarkers that distinguish individuals with obesity from lean individuals both before and after weight‐loss intervention. Comparative analyses revealed heterogeneous molecular responses to weight reduction, with some miRNAs showing ...
Yuan Yue, Rajesh Katare, Jeremiah Deng, Daniel Alencar Da Costa, Patrick Manning   +4 more
wiley   +1 more source

Neuroprotective Effects of RNS60 in TDP-43 Pathology-Associated Amyotrophic Lateral Sclerosis. [PDF]

Muscle Nerve
Vesevick DR, Ghosh S, Kalmes A, Ozdinler PH, Gautam M.   +4 more
europepmc   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, Volume 101, Issue 5, Page 2408-2426, October 2026.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source