Results 221 to 230 of about 995,258 (307)

A Motor Vehicle Crash as an Early Signal of Alzheimer's Disease and Related Dementias

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background People with Alzheimer's disease and related dementias (ADRD) are at increased risk of motor vehicle crash (MVC) due to cognitive decline, which often begins years before diagnosis. MVC could serve as an indicator of ADRD‐related cognitive impairment and facilitate earlier diagnosis.
Nina R. Joyce, Steven Balog, Rachel Gaither, Melissa R. Pfeiffer, Fiona Bhondoekhan, Brian R. Ott, Seth A. Margolis, Alison E. Curry, Andrew R. Zullo   +8 more
wiley   +1 more source

Beyond neurofilaments: a multidimensional blood signature for amyotrophic lateral sclerosis. [PDF]

Brain Commun
Thomas EV, Pant DC.
europepmc   +1 more source

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study

Journal of Anatomy, EarlyView.
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Chiara Galli, Georgia Colleluori, Jessica Perugini, Edoardo Scopini, Ilenia Severi, Gaia Grandin, Antonio Giordano   +6 more
wiley   +1 more source

Plasma exosomal HERV-K transcripts are increased in amyotrophic lateral sclerosis. [PDF]

BMC Neurosci
Roy T, Ramesh M, Nizam NAA, Tandiono S, Al-Jamal KT, Al-Chalabi A, Iacoangeli A, Al Khleifat A.   +7 more
europepmc   +1 more source

Neuroanatomy education through the years: Revisiting the teaching slides used by Sir Wilfrid Edward Le Gros Clark

Journal of Anatomy, EarlyView.
This paper examines the life and legacy of British anatomist Sir Wilfrid Le Gros Clark through his neuroanatomical teaching collection at the University of Oxford. The authors catalogued 103 specimens and analyzed selected slides—including cases of multiple sclerosis, amyotrophic lateral sclerosis, tabes dorsalis, syringomyelia, and the pineal gland's ...
Shiva A. Nischal, Kush M. Kale, Katherine Tourigny, Mohammed Abuelem, Gretchen Greene, Rachel Walsh, Zoltán Molnár   +6 more
wiley   +1 more source

From Mutation to Manifestation: Penetrance in Amyotrophic Lateral Sclerosis. [PDF]

Genes (Basel)
Richard E, Al-Hajj Vourc'h S, Marouillat S, Beltran S, Blasco H, Corcia P, Vourc'h P.   +6 more
europepmc   +1 more source

R‐Loops Mediated Odontogenic Differentiation of hDPSCs by Activating the cGAS‐STING Pathway Under Inflammatory Microenvironment

Oral Diseases, EarlyView.
ABSTRACT Background R‐Loops are three‐stranded DNA/RNA hybrids implicated in immune responses. Their role in mesenchymal stem cell differentiation, particularly in dental pulp regeneration under inflammation, remains unclear. Methods Rat pulpo‐dentinal complex (PDC) injury models and LPS‐stimulated human dental pulp stem cells (hDPSCs) were used.
Yun Yang, Yiqing Wang, Yating Miao, Zhipu Luo, Lin Niu, Ruirui Liu   +5 more
wiley   +1 more source

Neuropathological and Molecular Features Associated With a Heterozygous DNAJC7 Mutation in Amyotrophic Lateral Sclerosis. [PDF]

Neuropathol Appl Neurobiol
Nakayama Y, Kume K, Baba T, Ayaki T, Hanada K, Miyamoto K, Inoue N, Kawakami H, Ito H.   +8 more
europepmc   +1 more source

Evolutionary Conserved and Divergent Responses to Copper Zinc Superoxide Dismutase Inhibition in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT After an initial evolution in a reducing environment, life got successively challenged by reactive oxygen species (ROS), especially during the great oxidation event (GOE) that followed the development of photosynthesis. Therefore, ROS are deeply intertwined into the physiological, morphological and transcriptional responses of most present‐day
Stephanie Frohn, Fabian B. Haas, Benjamin G. Chavez, Bernd H. Dreyer, Erik V. Reiss, Anne Ziplys, Heiko Weichert, Saskia Hiltemann, José M. Ugalde, Andreas J. Meyer, John C. D'Auria, Stefan A. Rensing, Jos H. M. Schippers   +12 more
wiley   +1 more source

Bridging the gap: neuroinflammation and the dawn of precision medicine in amyotrophic lateral sclerosis. [PDF]

Transl Neurodegener
Tang L, Fan D.
europepmc   +1 more source