Results 211 to 220 of about 995,258 (307)

Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

The FEBS Journal, EarlyView.
Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester, Owen Leitzel, Samantha Golf, Chelsea M. Phillips, Michael J. Zeitz, Rahul Pandit, Elizabeth Wash, Jenna V. Donohue, Elizabeth A. Istre, James W. Smyth, Samy Lamouille, Stefanie Robel   +11 more
wiley   +1 more source

Prevalence and determinants of anxiety in amyotrophic lateral sclerosis. [PDF]

BJPsych Open
Aiello EN, De Luca G, Curti B, Torre S, Gendarini C, Cocuzza A, Colombo E, De Sandi A, Mellace D, Ferrucci R, Barbieri S, Maranzano A, Verde F, Messina S, Doretti A, Morelli C, Silani V, Ticozzi N, Poletti B.   +18 more
europepmc   +1 more source

Stimulating proteasomal degradation in human proteinopathies

The FEBS Journal, EarlyView.
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch, Enrica Barchi, Nico P. Dantuma   +2 more
wiley   +1 more source

Learning a distance for the clustering of patients with amyotrophic lateral sclerosis. [PDF]

BioData Min
Dominguez GTY, Alarcan H, Peralta V, Labroche N, Corcia P, Marcel P, Blasco H.   +6 more
europepmc   +1 more source

TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics

The FEBS Journal, EarlyView.
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga, Zsolt Ráduly, Beáta Boros‐Oláh, Éva Nagy, Zsolt Karányi, László Halász, Bálint László Bálint, György Vámosi, Emese Tóth, Péter Bai, Serena Santangelo, Patrizia Bossolasco, Antonia Ratti, Vincent Géli, Yves Pommier, Lóránt Székvölgyi   +15 more
wiley   +1 more source

Influence of micronutrients on anxiety and depression in patients with amyotrophic lateral sclerosis. [PDF]

Front Nutr
Sancho-Castillo S, Bargues-Navarro G, Cárdenas Salazar RG, Privado J, Sanchis-Sanchis E, Sancho-Cantus D, Sanchis-Sanchis CE, Cubero-Plazas L, Cano Mateu M, de la Rubia Ortí JE.   +9 more
europepmc   +1 more source

Correlation of quality of life and motor impairment in amyotrophic lateral sclerosis

, 2008
LOMBARDI A. CORRELATION OF QUALITY OF LIFE AND MOTOR IMPAIRMENT IN AMYOTROPHIC LATERAL SCLEROSIS, PALMIERI, ARIANNA, SORARU', GIANNI   +2 more
core  

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, EarlyView.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

Oligonucleotide-siRNA conjugate for SOD1 amyotrophic lateral sclerosis: a phase 1 trial. [PDF]

Nat Med
Chen W, Jiang L, Duan C, Kang M, Ye J, Wang L, Pan Y, Qu H, Liao X, Zhou X, Li Y, Gan Z, Chen J, Schacht I, Place RF, Li LC, Wang Y.   +16 more
europepmc   +1 more source