Results 1 to 10 of about 302,721 (262)
Motor neurons and the generation of spinal motor neurons diversity [PDF]
Frontiers in Cellular Neuroscience, 2014 Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS) controlling a variety of downstream targets. This function infers the existence of MN subtypes matching the identity of the targets they innervate.
Nicolas eStifani
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Molecular Therapy - Methods and Clinical Development, 2020 The motor system controls muscle movement through lower motor neurons in the spinal cord and brainstem. Lower motor neurons are efferent neurons in the central nervous system (CNS) characterized by axonal projections that reach specific targets in the ...
Guoqing Fan, Anan Li, Jing Yuan
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Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases [PDF]
PLoS Genetics, 2017 The term "motor neuron disease" encompasses a spectrum of disorders in which motor neurons are the primary pathological target. However, in both patients and animal models of these diseases, not all motor neurons are equally vulnerable, in that while ...
Rachel A Kline +2 more
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Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization [PDF]
eLifeSensorimotor reflex circuits engage distinct neuronal subtypes, defined by precise connectivity, to transform sensation into compensatory behavior. Whether and how motor neuron populations specify the subtype fate and/or sensory connectivity of their pre-
Dena Goldblatt +9 more
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Neurobiology of Disease, 2005 Amyotrophic lateral sclerosis (ALS) is characterized by a progressive loss of large motor neurons in the brain and spinal cord. Amyloid precursor protein (APP), the transmembrane precursor of β-amyloid (Aβ), accumulates in the anterior horn motor neurons
Noel Y Calingasan +2 more
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Stem Cell Reports, 2017 Summary: Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease. Astrocytic factors are known to contribute to motor neuron degeneration and death in ALS.
Natalia Rodríguez-Muela +2 more
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Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes
eLife, 2023 Complex motor skills in vertebrates require specialized upper motor neurons with precise action potential (AP) firing. To examine how diverse populations of upper motor neurons subserve distinct functions and the specific repertoire of ion channels ...
Benjamin M Zemel +7 more
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Motor neurons in the escape response circuit of white shrimp (Litopenaeus setiferus) [PDF]
PeerJ, 2015 Many decapod crustaceans perform escape tailflips with a neural circuit involving giant interneurons, a specialized fast flexor motor giant (MoG) neuron, populations of larger, less specialized fast flexor motor neurons, and fast extensor motor neurons ...
Zen Faulkes
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Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS
iScience, 2021 Summary: The neuromuscular junction is a synapse critical for muscle strength and coordinated motor function. Unlike CNS injuries, motor neurons mount robust regenerative responses after peripheral nerve injuries.
Jennifer L. Shadrach +6 more
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A size principle for recruitment of Drosophila leg motor neurons
eLife, 2020 To move the body, the brain must precisely coordinate patterns of activity among diverse populations of motor neurons. Here, we use in vivo calcium imaging, electrophysiology, and behavior to understand how genetically-identified motor neurons control ...
Anthony W Azevedo +5 more
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