Results 41 to 50 of about 1,754,547 (304)
Co-occurrence of TDP-43 mislocalization with reduced activity of an RNA editing enzyme, ADAR2, in aged mouse motor neurons. [PDF]
PLoS ONE, 2012 TDP-43 pathology in spinal motor neurons is a neuropathological hallmark of sporadic amyotrophic lateral sclerosis (ALS) and has recently been shown to be closely associated with the downregulation of an RNA editing enzyme called adenosine deaminase ...
Takuto Hideyama +4 more
doaj +1 more source
Modulation of motor behavior by the mesencephalic locomotor region
Cell Reports, 2021 Summary: The mesencephalic locomotor region (MLR) serves as an interface between higher-order motor systems and lower motor neurons. The excitatory module of the MLR is composed of the pedunculopontine nucleus (PPN) and the cuneiform nucleus (CnF), and ...
Daniel Dautan +5 more
doaj +1 more source
The Peroxisome Proliferator-activated Receptor γ (PPARγ) Controls Natural Protective Mechanisms against Lipid Peroxidation in Amyotrophic Lateral Sclerosis [PDF]
, 2012 Recent evidence highlights the peroxisome proliferator-activated receptors (PPARs) as critical neuroprotective factors in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). To gain new mechanistic insights into the role of
Maggi, Adriana +8 more
core +1 more source
Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution.
PLoS Genetics, 2015 Functional diversification of motor neurons has occurred in order to selectively control the movements of different body parts including head, trunk and limbs.
Namhee Kim +3 more
doaj +1 more source
Postgraduate Medical Journal, 2002 Abstract Motor neurone disease (MND), or amyotrophic lateral sclerosis (ALS), is a neurodegenerative disorder of unknown aetiology. Progressive motor weakness and bulbar dysfunction lead to premature death, usually from respiratory failure. Confirming the diagnosis may initially be difficult until the full clinical features are manifest.
openaire +3 more sources
Motor Band Sign in Motor Neuron Disease: A Marker for Upper Motor Neuron Involvement
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2022 ABSTRACT:Background and Objective:The prevalence and role of the motor band sign (MBS) remain unclear in motor neuron disease. We report the frequency of MBS in amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS), its correlation with clinical upper motor neuron (UMN) signs, and prognostic value in ALS.Methods:We conducted a ...
Hee Sahng Chung +3 more
openaire +2 more sources
Nitric oxide synthase and the contribution of nitric oxide to vertebrate motor control [PDF]
, 2008 I have explored the role of nitric oxide (NO) and the distribution of its synthetic enzyme in neurons, nNOS, in vertebrate motor control. The CNS of Xenopus laevis tadpoles was used primarily in this investigation as a developmental model of neural ...
Molinari, Micol Ariella
core +2 more sources
Stem Cells International, 2016 The Charcot-Marie-Tooth disease 2F (CMT2F) and distal hereditary motor neuropathy 2B (dHMN2B) are caused by autosomal dominantly inherited mutations of the heat shock 27 kDa protein 1 (HSPB1) gene and there are no specific therapies available yet.
Ji-Yon Kim +11 more
doaj +1 more source
Nature Communications, 2023 Insults to the developing cerebellum can cause motor, language, and social deficits. Here, we investigate whether developmental insults to different cerebellar neurons constrain the ability to acquire cerebellar-dependent behaviors. We perturb cerebellar
Meike E. van der Heijden +6 more
doaj +1 more source
Molecular pathways of proprioceptive dorsal root ganglion (DRG) sensory neuron specification [PDF]
, 2005 Dorsal root ganglia (DRG) sensory neurons can be classified into distinct neuronal subpopulations based on the expression of specific receptor tyrosine kinases known as neurotrophic factor receptors.
Kramer, Ina
core +1 more source