Results 41 to 50 of about 1,690,268 (304)

Modulation of motor behavior by the mesencephalic locomotor region

Cell Reports, 2021
Summary: The mesencephalic locomotor region (MLR) serves as an interface between higher-order motor systems and lower motor neurons. The excitatory module of the MLR is composed of the pedunculopontine nucleus (PPN) and the cuneiform nucleus (CnF), and ...
Daniel Dautan, Adrienn Kovács, Tsogbadrakh Bayasgalan, Miguel A. Diaz-Acevedo, Balazs Pal, Juan Mena-Segovia   +5 more
doaj   +1 more source

Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution.

PLoS Genetics, 2015
Functional diversification of motor neurons has occurred in order to selectively control the movements of different body parts including head, trunk and limbs.
Namhee Kim, Chungoo Park, Yongsu Jeong, Mi-Ryoung Song   +3 more
doaj   +1 more source

Motor neurone disease [PDF]

Postgraduate Medical Journal, 2002
Abstract Motor neurone disease (MND), or amyotrophic lateral sclerosis (ALS), is a neurodegenerative disorder of unknown aetiology. Progressive motor weakness and bulbar dysfunction lead to premature death, usually from respiratory failure. Confirming the diagnosis may initially be difficult until the full clinical features are manifest.
openaire   +3 more sources

Motor Band Sign in Motor Neuron Disease: A Marker for Upper Motor Neuron Involvement

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2022
ABSTRACT:Background and Objective:The prevalence and role of the motor band sign (MBS) remain unclear in motor neuron disease. We report the frequency of MBS in amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS), its correlation with clinical upper motor neuron (UMN) signs, and prognostic value in ALS.Methods:We conducted a ...
Hee Sahng Chung, Gerd Melkus, Pierre Bourque, Santanu Chakraborty   +3 more
openaire   +2 more sources

The homeobox transcription factor Even-skipped regulates acquisition of electrical properties in Drosophila neurons [PDF]

, 2006
Background While developmental processes such as axon pathfinding and synapse formation have been characterized in detail, comparatively less is known of the intrinsic developmental mechanisms that regulate transcription of ion channel genes in ...
Southall Tony D, Southall, Tony D., Baines, Richard A., Richard A Baines, Southall, TD, Pym, Edward C.G., Brand, Andrea H., Tony D Southall, Baines, RA; id_orcid, Mee Christopher J, Pym Edward CG, Brand, AH, Brand Andrea H, Mee, CJ, Edward CG Pym, Mee, Christopher J., Pym, ECG, Baines Richard A, Christopher J Mee, Andrea H Brand   +19 more
core   +3 more sources

HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation

Stem Cells International, 2016
The Charcot-Marie-Tooth disease 2F (CMT2F) and distal hereditary motor neuropathy 2B (dHMN2B) are caused by autosomal dominantly inherited mutations of the heat shock 27 kDa protein 1 (HSPB1) gene and there are no specific therapies available yet.
Ji-Yon Kim, So-Youn Woo, Young Bin Hong, Heesun Choi, Jisoo Kim, Hyunjung Choi, Inhee Mook-Jung, Nina Ha, Jangbeen Kyung, Soo Kyung Koo, Sung-Chul Jung, Byung-Ok Choi   +11 more
doaj   +1 more source

Glutamatergic cerebellar neurons differentially contribute to the acquisition of motor and social behaviors

Nature Communications, 2023
Insults to the developing cerebellum can cause motor, language, and social deficits. Here, we investigate whether developmental insults to different cerebellar neurons constrain the ability to acquire cerebellar-dependent behaviors. We perturb cerebellar
Meike E. van der Heijden, Alejandro G. Rey Hipolito, Linda H. Kim, Dominic J. Kizek, Ross M. Perez, Tao Lin, Roy V. Sillitoe   +6 more
doaj   +1 more source

Motor Neurons that Multitask [PDF]

Neuron, 2012
Animals use a form of sensory feedback termed proprioception to monitor their body position and modify the motor programs that control movement. In this issue of Neuron, Wen et al. (2012) provide evidence that a subset of motor neurons function as proprioceptors in C.
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Scaling proprioceptor gene transcription by retrograde NT3 signaling [PDF]

, 2011
The assembly of neuronal circuits depends critically on the sequential activation of transcriptional programs in defined neuronal sub-populations. In the spinal cord, retrograde signaling interactions from the periphery have been shown to be essential ...
Lee, Jun
core   +1 more source