Results 21 to 30 of about 1,690,268 (304)

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. [PDF]

PLoS ONE, 2015
Cell adhesion molecules belonging to the immunoglobulin superfamily (IgSF) control synaptic specificity through hetero- or homophilic interactions in different regions of the nervous system.
Zirong Gu, Fumiyasu Imai, In Jung Kim, Hiroko Fujita, Kei ichi Katayama, Kensaku Mori, Yoshihiro Yoshihara, Yutaka Yoshida   +7 more
doaj   +1 more source

Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease [PDF]

, 2015
Background Patients with advanced Parkinson's disease (PD) often present with axial symptoms, including postural- and gait difficulties that respond poorly to dopaminergic agents.
Pienaar, Ilse, De Paola, V, Gretenkord, Sabine, David Dexter (3572210), Sabine Gretenkord, Withers, Dominic, Ilse Pienaar (4504357), Dominic Withers (3572216), Gartside, Sarah, De Paola, Vincenzo, Puneet Sharma, Ilse S. Pienaar, Puneet Sharma (3572222), Sharma, Puneet, Dominic Withers, Sabine Gretenkord (3572213), David T. Dexter, Vincenzo De Paola, Joanna L. Elson, Ilse Pienaar (3572219), Joanna L Elson (16036517), Sarah Gartside (3572225), Dexter, David, Elson, Joanna, Sarah E. Gartside, Joanna Elson (271089), Vincenzo De Paola (275215), Sarah E Gartside (16264538), David T Dexter (9237410)   +28 more
core   +1 more source

ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.

PLoS Biology, 2022
The ability of terrestrial vertebrates to effectively move on land is integrally linked to the diversification of motor neurons into types that generate muscle force (alpha motor neurons) and types that modulate muscle proprioception, a task that in ...
Mudassar N Khan, Pitchaiah Cherukuri, Francesco Negro, Ashish Rajput, Piotr Fabrowski, Vikas Bansal, Camille Lancelin, Tsung-I Lee, Yehan Bian, William P Mayer, Turgay Akay, Daniel Müller, Stefan Bonn, Dario Farina, Till Marquardt   +14 more
doaj   +1 more source

Gene profiling of identified neurons to dissect molecular mechanisms involved in spinal reflex assembly [PDF]

, 2010
The central question during my PhD studies was to understand the molecular mechanisms and genetic cascades controlling the sequential specification of distinct classes of dorsal root ganglia (DRG) sensory neurons, with a particular focus on genes ...
Friese, Andreas
core   +1 more source

Morphological characteristics of motor neurons do not determine their relative susceptibility to degeneration in a mouse model of severe spinal muscular atrophy. [PDF]

PLoS ONE, 2012
Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality, resulting primarily from the degeneration and loss of lower motor neurons.
Sophie R Thomson, Joya E Nahon, Chantal A Mutsaers, Derek Thomson, Gillian Hamilton, Simon H Parson, Thomas H Gillingwater   +6 more
doaj   +1 more source

Motor neurone disease [PDF]

BMJ, 1996
In patients with motor neurone disease, progressively worsening breathlessness often coincides with deteriorating bulbar function, and this combination may lead to difficulties in swallowing and coughing and a risk of aspiration. Occasionally, chest infections cause life threatening respiratory failure.
openaire   +2 more sources

Microglial responses around intrinsic CNS neurons are correlated with axonal regeneration [PDF]

, 2010
Background: Microglia/macrophages and lymphocytes (T-cells) accumulate around motor and primary sensory neurons that are regenerating axons but there is little or no microglial activation or T-cell accumulation around axotomised intrinsic CNS neurons ...
Bernadette ZY Wong, Shokouhi, B.N., Lieberman, A.R., Tohyama, K., Wong Bernadette ZY, Campbell, G., Koujiro Tohyama, Anderson Patrick N, Gregor Campbell, Tohyama Koujiro, Campbell Gregor, Samir Siddiqui, Siddiqui, S., Patrick N Anderson, A Robert Lieberman, Bahman N Shokouhi, Wong, B.Z.Y., Shokouhi Bahman N, Anderson, P.N., Lieberman A Robert, Siddiqui Samir   +20 more
core   +1 more source

Abnormal mitochondrial transport and morphology as early pathological changes in human models of spinal muscular atrophy

Disease Models & Mechanisms, 2016
Spinal muscular atrophy (SMA), characterized by specific degeneration of spinal motor neurons, is caused by mutations in the survival of motor neuron 1, telomeric (SMN1) gene and subsequent decreased levels of functional SMN. How the deficiency of SMN, a
Chong-Chong Xu, Kyle R. Denton, Zhi-Bo Wang, Xiaoqing Zhang, Xue-Jun Li   +4 more
doaj   +1 more source

Locomotor deficits in a mouse model of ALS are paralleled by loss of V1-interneuron connections onto fast motor neurons

Nature Communications, 2021
Here the authors show in a model of ALS that motor neurons receive stronger inhibitory synaptic inputs than slow motor neurons, and disease progression is associated with specific loss of inhibitory synapses onto fast motor neurons.
Ilary Allodi, Roser Montañana-Rosell, Raghavendra Selvan, Peter Löw, Ole Kiehn   +4 more
doaj   +1 more source

Differential NPY-Y1 Receptor Density in the Motor Cortex of ALS Patients and Familial Model of ALS

Brain Sciences, 2021
Destabilization of faciliatory and inhibitory circuits is an important feature of corticomotor pathology in amyotrophic lateral sclerosis (ALS). While GABAergic inputs to upper motor neurons are reduced in models of the disease, less understood is the ...
Courtney M. Clark, Rosemary M. Clark, Joshua A. Hoyle, Jyoti A. Chuckowree, Catriona A. McLean, Tracey C. Dickson   +5 more
doaj   +1 more source