Results 11 to 20 of about 1,690,268 (304)
Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development [PDF]
Frontiers in Cellular Neuroscience, 2016 Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN
Heidi R Fuller +12 more
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Neurons other than motor neurons in motor neuron disease. [PDF]
Histology and histopathology, 2017 Amyotrophic lateral sclerosis (ALS) is typically defined by a loss of motor neurons in the central nervous system. Accordingly, morphological analysis for decades considered motor neurons (in the cortex, brainstem and spinal cord) as the neuronal population selectively involved in ALS.
Ruffoli R +7 more
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JCI Insight, 2023 Spinal motor neurons have been implicated in the loss of motor function that occurs with advancing age. However, the cellular and molecular mechanisms that impair the function of these neurons during aging remain unknown. Here, we show that motor neurons
Ryan W. Castro +3 more
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BMJ, 2011 Diane Sackett experienced the first symptoms of motor neurone disease in 2004, and died in September 2009. Diane’s husband, Brian, was her main carer.
Brian, Sackett, Mohamed, Sakel
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GABAergic motor neurons bias locomotor decision-making in C. elegans
Nature Communications, 2020 Motor neurons are generally considered to be passive receivers of commands from other neurons. However, this study shows that motor neurons may shape locomotor behaviour by regulating premotor neurons, and that premotor neurons serve to integrate ...
Ping Liu, Bojun Chen, Zhao-Wen Wang
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Distinct Corticostriatal GABAergic Neurons Modulate Striatal Output Neurons and Motor Activity
Cell Reports, 2017 Summary: The motor cortico-basal ganglion loop is critical for motor planning, execution, and learning. Balanced excitation and inhibition in this loop is crucial for proper motor output.
Sarah Melzer +5 more
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Neural basis of a visuo-motor transformation in the fly [PDF]
, 2009 How the outputs of populations of sensory neurons are used by motor systems to generate appropriate behaviour is a long standing question in neuroscience. I address this problem by studying a comparatively simple model system.
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Boundary cap cells constrain spinal motor neuron somal migration at motor exit points by a semaphorin-plexin mechanism [PDF]
, 2007 In developing neurons, somal migration and initiation of axon outgrowth often occur simultaneously and are regulated in part by similar classes of molecules. When neurons reach their final destinations, however, somal translocation and axon extension are
Mitchell, KJ +13 more
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Cortical and subcortical somatosensory regulation of dopaminergic neurons: role of the superior colliculus [PDF]
, 2011 Dopaminergic (DA) neurons exhibit a short-latency, phasic response to unexpected biologically salient stimuli, including rewards. Despite extensive research on this DA signal, very little is known about the sources of sensory ...
Bertram, Craig
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Cross-modal sensory signaling shapes vestibulo-motor circuit specificity [PDF]
, 2015 The ability to continuously adjust posture and balance is necessary for reliable motor behavior. Vestibular and proprioceptive systems influence postural adjustments during movement by signaling functionally complementary sensory information. Using
Basaldella, Emanuela
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