Results 31 to 40 of about 553,827 (305)
Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons
Cell Reports, 2023 Summary: Dysregulated neuronal excitability is a hallmark of amyotrophic lateral sclerosis (ALS). We sought to investigate how functional changes to the axon initial segment (AIS), the site of action potential generation, could impact neuronal ...
Peter Harley +9 more
doaj +1 more source
Comparing Offline Decoding Performance in Physiologically Defined Neuronal Classes [PDF]
, 2016 Objective: Recently, several studies have documented the presence of a bimodal distribution of spike waveform widths in primary motor cortex. Although narrow and wide spiking neurons, corresponding to the two modes of the distribution, exhibit different ...
Best, Matthew D. +5 more
core +2 more sources
Neurobiology of Disease, 2012 In amyotrophic lateral sclerosis (ALS) some motor neurons degenerate while others survive. The molecular mechanisms underlying this selective vulnerability and resistance, respectively, are poorly understood.
Cornelia Ringer +2 more
doaj +1 more source
Prepontine non-giant neurons drive flexible escape behavior in zebrafish [PDF]
, 2019 Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level.
Bergeron, S. +4 more
core +2 more sources
Frontiers in Cellular Neuroscience, 2016 Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN
Heidi R Fuller +12 more
doaj +1 more source
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. [PDF]
, 2013 Oligodendrocytes associate with axons to establish myelin and provide metabolic support to neurons. In the spinal cord of amyotrophic lateral sclerosis (ALS) mice, oligodendrocytes downregulate transporters that transfer glycolytic substrates to neurons ...
Bergles, Dwight E +7 more
core +2 more sources
Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease [PDF]
, 2018 Human Ag R (HuR) is an RNA binding protein in the ELAVL protein family. To study the neuron-specific function of HuR, we generated inducible, neuron-specific HuR-deficient mice of both sexes.
Bai, Ying +10 more
core +1 more source
State Variables of the Arm May Be Encoded by Single Neuron Activity in the Monkey Motor Cortex [PDF]
, 2016 Revealing the type of information encoded by neurons activity in the motor cortex is essential not only for understanding the mechanism of motion control but also for developing a brain-machine interface.
Eizo Miyashita, Yutaka Sakaguchi
core +2 more sources
BMJ, 1996 In patients with motor neurone disease, progressively worsening breathlessness often coincides with deteriorating bulbar function, and this combination may lead to difficulties in swallowing and coughing and a risk of aspiration. Occasionally, chest infections cause life threatening respiratory failure.
openaire +2 more sources
Modulation of motor behavior by the mesencephalic locomotor region
Cell Reports, 2021 Summary: The mesencephalic locomotor region (MLR) serves as an interface between higher-order motor systems and lower motor neurons. The excitatory module of the MLR is composed of the pedunculopontine nucleus (PPN) and the cuneiform nucleus (CnF), and ...
Daniel Dautan +5 more
doaj +1 more source