Results 51 to 60 of about 1,690,268 (304)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila

G3: Genes, Genomes, Genetics, 2019
The Drosophila melanogaster larval neuromuscular system is extensively used by researchers to study neuronal cell biology, and Drosophila glutamatergic motor neurons have become a major model system.
Juan J. Pérez-Moreno, Cahir J. O’Kane
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

fMRI evidence of ‘mirror’ responses to geometric shapes [PDF]

, 2012
Mirror neurons may be a genetic adaptation for social interaction [1]. Alternatively, the associative hypothesis [2], [3] proposes that the development of mirror neurons is driven by sensorimotor learning, and that, given suitable experience, mirror ...
Heyes, C., Heyes Cecilia, Widmann, H, Clare Press, Press, C., Bird Geoffrey, Catmur, C, Press, C, Heyes, C, Cook, R, Bird, G., Cecilia Heyes, Cook Richard, Geoffrey Bird, Press Clare, Avenanti, A., Widmann Hannah, Heyes, Cecilia, Richard Cook, Bird, Geoffrey; id_orcid, Cook, R., Catmur, Caroline; id_orcid, Widmann, Hannah, Hannah Widmann, Bird, G, Widmann, H., Bird, Geoffrey, Heyes, Cecelia, Catmur, C., Catmur Caroline, Clare Press, Cook, Richard; id_orcid, Press, Clare, Caroline Catmur   +33 more
core   +2 more sources

Heavy metals in locus ceruleus and motor neurons in motor neuron disease [PDF]

Acta Neuropathologica Communications, 2013
The causes of sporadic amyotrophic lateral sclerosis (SALS) and other types of motor neuron disease (MND) remain largely unknown. Heavy metals have long been implicated in MND, and it has recently been shown that inorganic mercury selectively enters human locus ceruleus (LC) and motor neurons. We therefore used silver nitrate autometallography (AMG) to
Pamphlett, Roger, Kum Jew, Stephen
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans [PDF]

, 2006
The diversity of sensory cilia on Caenorhabditis elegans neurons allows the animal to detect a variety of sensory stimuli. Sensory cilia are assembled by intraflagellar transport (IFT) kinesins, which transport ciliary precursors, bound to IFT particles,
James E. Evans, Kent L. McDonald, Amy L. Gunnarson, Gunnarson, Amy L., Guangshuo Ou, Snow, JJ, McDonald, KL, Stahlberg, Henning, Ou, Guangshuo, Ou, GS, Evans, JE, Stahlberg, H, Evans, James E., Jonathan M. Scholey, Scholey, JM, Gunnarson, AL, McDonald, Kent L., Joshua J. Snow, Henning Stahlberg, Snow, Joshua J., Scholey, Jonathan M.   +20 more
core   +1 more source

Adenylyl Cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice

BMC Neuroscience, 2011
Background The primary cilium is a solitary organelle important in cellular signaling, that projects from the cell surface of most growth-arrested or post-mitotic cells including neurons in the central nervous system.
Turnbull John, Peterson Randy, Ma Xiaoxing   +2 more
doaj   +1 more source

Tracheostomy in motor neurone disease

Practical Neurology, 2019
Tracheostomy-associated ventilation for the respiratory insufficiency caused by amyotrophic lateral sclerosis (motor neurone disease (MND)) is a complex issue with practical, ethical and economic dimensions. This article considers the current prevalence of tracheostomy in MND, the evidence for its benefit both for survival and quality of life, and the ...
Martin R Turner, Christina Faull, Christopher J McDermott, Annabel H Nickol, Jonathan Palmer, Kevin Talbot   +5 more
openaire   +3 more sources