Results 61 to 70 of about 1,754,547 (304)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Tracheostomy in motor neurone disease

Practical Neurology, 2019
Tracheostomy-associated ventilation for the respiratory insufficiency caused by amyotrophic lateral sclerosis (motor neurone disease (MND)) is a complex issue with practical, ethical and economic dimensions. This article considers the current prevalence of tracheostomy in MND, the evidence for its benefit both for survival and quality of life, and the ...
Martin R Turner, Christina Faull, Christopher J McDermott, Annabel H Nickol, Jonathan Palmer, Kevin Talbot   +5 more
openaire   +3 more sources

The homeobox transcription factor Even-skipped regulates acquisition of electrical properties in Drosophila neurons [PDF]

, 2006
Background While developmental processes such as axon pathfinding and synapse formation have been characterized in detail, comparatively less is known of the intrinsic developmental mechanisms that regulate transcription of ion channel genes in ...
Southall Tony D, Southall, Tony D., Baines, Richard A., Richard A Baines, Southall, TD, Pym, Edward C.G., Brand, Andrea H., Tony D Southall, Baines, RA; id_orcid, Mee Christopher J, Pym Edward CG, Brand, AH, Brand Andrea H, Mee, CJ, Edward CG Pym, Mee, Christopher J., Pym, ECG, Baines Richard A, Christopher J Mee, Andrea H Brand   +19 more
core   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Adenylyl Cyclase type 3, a marker of primary cilia, is reduced in primary cell culture and in lumbar spinal cord in situ in G93A SOD1 mice

BMC Neuroscience, 2011
Background The primary cilium is a solitary organelle important in cellular signaling, that projects from the cell surface of most growth-arrested or post-mitotic cells including neurons in the central nervous system.
Turnbull John, Peterson Randy, Ma Xiaoxing   +2 more
doaj   +1 more source

Maturation of spinal motor neurons derived from human embryonic stem cells. [PDF]

PLoS ONE, 2012
Our understanding of motor neuron biology in humans is derived mainly from investigation of human postmortem tissue and more indirectly from live animal models such as rodents.
Tomonori Takazawa, Gist F Croft, Mackenzie W Amoroso, Lorenz Studer, Hynek Wichterle, Amy B Macdermott   +5 more
doaj   +1 more source

Nuclear expression of PG-21, SRC-1, and pCREB in regions of the lumbosacral spinal cord involved in pelvic innervation in young adult and aged rats [PDF]

, 2012
In rats, ageing results in dysfunctional patterns of micturition and diminished sexual reflexes that may reflect degenerative changes within spinal circuitry.
Ranson, R. N., Connelly, Jennifer, Santer, Robert Murray, Watson, Alan, Ranson, Richard, Watson, Alan Hugh David, Santer, Robert, Connelly, J. H.   +7 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression

Neurobiology of Disease, 2018
The selective vulnerability of motor neurons in amyotrophic lateral sclerosis (ALS) is evident by sparing of a few subpopulations during this fast progressing and debilitating degenerative disease. By studying the gene expression profile of resilient vs.
Teresia M. Osborn, Jonathan Beagan, Ole Isacson   +2 more
doaj   +1 more source

RESTORATION OF MOTOR AND NON-MOTOR FUNCTIONS BY NEUROTROPHIC FACTORS IN NONHUMAN PRIMATES WITH DOPAMINE DEPLETION [PDF]

, 2013
Parkinson’s disease (PD) is a progressive debilitating neurodegenerative disorder characterized by resting tremor, rigidity, bradykinesia and postural instability. As the disease progresses there is a loss of dopamine (DA) neurons in the substantia nigra
Subramanian, Krishna
core