Results 81 to 90 of about 1,754,547 (304)
Optogenetic methods to stimulate gamma motor neuron axons ex vivo
Experimental PhysiologyIt is challenging to stimulate gamma motor neurons, which are important regulators of muscle spindle afferent function, without also recruiting alpha motor neurons.
Apoorva Karekal +7 more
doaj +1 more source
cDNA that encodes active agrin [PDF]
, 1992 Agrin is thought to mediate the motor neuron-induced aggregation of AChRs and AChE on the surface of muscle fibers at neuromuscular junctions. We have isolated a cDNA from a chick brain library that, based on sequence homology and expression experiments,
Kröger, Stephan +9 more
core +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Stimulation of motor tracts in motor neuron disease. [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1987 The muscle responses evoked by cortical and cervical stimulation in 11 patients with motor neuron disease were studied. The muscle potential in the abductor pollicis brevis, evoked by median nerve stimulation and the somatosensory potential evoked by wrist stimulation were also studied.
BERARDELLI, Alfredo +4 more
openaire +2 more sources
Hierarchies, Spikes, and Hybrid Systems: Physiologically Inspired Control Problems [PDF]
, 2011 In animal motor control and locomotion, neurons process information, muscles are the actuators, and the body is the plant. Control theory is the standard mathematical language for describing motor control and locomotion, but many phenomena in ...
Lamperski, Andrew G.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Nos1+ neurons are critical for motor learning and post-stroke motor recovery
Cell ReportsSummary: Motor learning has strong significance for motor recovery after stroke. Although layer-specific patterns of circuit connectivity in the primary motor cortex (M1) are well established, cell type-specific responses to motor learning remain elusive.
Yu-Hui Lin +12 more
doaj +1 more source
Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy. [PDF]
PLoS ONE, 2014 Spinal muscular atrophy (SMA) is an autosomal recessive disorder leading to paralysis and early death due to reduced SMN protein. It is unclear why there is such a profound motor neuron loss, but recent evidence from fly and mouse studies indicate that ...
Andrew J Schwab, Allison D Ebert
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures. [PDF]
PLoS ONE, 2014 Human motor neurons derived from embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are a potentially important tool for studying motor neuron survival and pathological cell death.
Nuno Jorge Lamas +6 more
doaj +1 more source