Results 91 to 100 of about 1,690,268 (304)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dissociating object directed and non-object directed action in the human mirror system; implications for theories of motor simulation. [PDF]

, 2012
Mirror neurons are single cells found in macaque premotor and parietal cortices that are active during action execution and observation. In non-human primates, mirror neurons have only been found in relation to object-directed movements or communicative ...
Wise, RJ, Leech, R, Agnew, ZK
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Intracranial Transplant of Olfactory Ensheathing Cells Can Protect Both Upper and Lower Motor Neurons in Amyotrophic Lateral Sclerosis

Cell Transplantation, 2013
Amyotrophic lateral sclerosis (ALS) is a fatal disease that involves the degeneration of cortical and spinal motor neurons. Mutant SOD1 G93A rats constitute a good animal model for this pathological condition.
Ying Li, Lin Chen, Yanxiu Zhao, Jianling Bao, Juan Xiao, Jingyuan Liu, Xiaorong Jiang, Changman Zhou, Hongmei Wang, Hongyun Huang   +9 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization

eLife
Sensorimotor reflex circuits engage distinct neuronal subtypes, defined by precise connectivity, to transform sensation into compensatory behavior. Whether and how motor neuron populations specify the subtype fate and/or sensory connectivity of their pre-
Dena Goldblatt, Basak Rosti, Kyla Rose Hamling, Paige Leary, Harsh Panchal, Marlyn Li, Hannah Gelnaw, Stephanie Huang, Cheryl Quainoo, David Schoppik   +9 more
doaj   +1 more source

Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons

Neurobiology of Disease, 2012
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset fatal motor neuron disease. In spinal motor neurons of patients with sporadic ALS, normal RNA editing of GluA2, a subunit of the L-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ...
Takuto Hideyama, Takenari Yamashita, Hitoshi Aizawa, Shoji Tsuji, Akiyoshi Kakita, Hitoshi Takahashi, Shin Kwak   +6 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons [PDF]

, 2002
Signaling by brain-derived neurotrophic factor (BDNF) via the TrkB receptor, or by neurotrophin-3 (NT3) through the TrkC receptor support distinct populations of sensory neurons.
Schimmang, Thomas, Lewin, G. R., Lewin, Gary R, Klein, R.*, Klein, R., Lewin, G.R., Fritzsch, B., Minichiello, L.*, Calella, A. M., Minichiello, Liliana, Klein, Rüdiger, Katz, David, Eilers, A., Schimmang, T., Minichiello, L., Lewin, G., Katz, D., Postigo, A., Calella, A.M., *Corresponding authors, Calella, A., Fritzsch, Bernd, Knipper, M., Postigo, Antonio, Eilers, Andreas, Calella, Anna Maria, Knipper, Marlies   +26 more
core   +1 more source