Results 61 to 70 of about 148,501 (250)

What causes amyotrophic lateral sclerosis? [version 1; referees: 3 approved]

F1000Research, 2017
Amyotrophic lateral sclerosis is a neurodegenerative disease predominantly affecting upper and lower motor neurons, resulting in progressive paralysis and death from respiratory failure within 2 to 3 years. The peak age of onset is 55 to 70 years, with a
Sarah Martin, Ahmad Al Khleifat, Ammar Al-Chalabi   +2 more
doaj   +1 more source

Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis.

JAMA Neurology, 2019
Importance Heritability describes the proportion of variance in the risk of developing a condition that is explained by genetic factors. Although amyotrophic lateral sclerosis (ALS) is known to have a complex genetic origin, disease heritability remains ...
M. Ryan, M. Heverin, R. Mclaughlin, O. Hardiman   +3 more
semanticscholar   +1 more source

ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization

Brain Communications, 2020
Increasingly, repeat expansions are being identified as part of the complex genetic architecture of amyotrophic lateral sclerosis. To date, several repeat expansions have been genetically associated with the disease: intronic repeat expansions in C9orf72,
Gijs H. P. Tazelaar, S. Boeynaems, Mathias De Decker, J. V. van Vugt, L. Kool, H. S. Goedee, R. Mclaughlin, W. Sproviero, A. Iacoangeli, M. Moisse, M. Jacquemyn, D. Daelemans, Annelot M. Dekker, Rick A. A. van der Spek, H. Westeneng, K. Kenna, A. Assialioui, Nica Da Silva, M. Povedano, J. M. Pardina, O. Hardiman, F. Salachas, S. Millecamps, P. Vourc'h, P. Corcia, P. Couratier, K. Morrison, P. Shaw, C. Shaw, R. Pasterkamp, J. Landers, L. Van Den Bosch, W. Robberecht, A. Al-Chalabi, L. H. van den Berg, P. van Damme, J. Veldink, M. V. van Es   +37 more
semanticscholar   +1 more source

Neuroimaging in Amyotrophic Lateral Sclerosis

Biomarkers in Medicine, 2012
The catastrophic system failure in amyotrophic lateral sclerosis is characterized by progressive neurodegeneration within the corticospinal tracts, brainstem nuclei and spinal cord anterior horns, with an extra-motor pathology that has overlap with frontotemporal dementia.
Turner, Mr, Agosta, F, Bede, P, Govind, V, Lulé, D, Verstraete, E.   +5 more
openaire   +4 more sources

Anesthetic considerations for laparoscopy for rectal cancer in patient with amyotrophic lateral sclerosis: A case report

Egyptian Journal of Anaesthesia, 2018
Amyotrophic lateral sclerosis, which is also known as motor neuron disease, is a chronic neurodegenerative disease characterized by progressive muscular weakness, respiratory muscle disability, and eventual death.
Bo-Ra Kim, Young-Bok Lee, Su-Jin Kim, Young-Wan Kim   +3 more
doaj  

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis: a retrospective observational study

Neural Regeneration Research
Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons. Early bilateral limb involvement significantly affects patients’ daily lives and may lead them to be confined to bed.
Jieying Wu, Shan Ye, Xiangyi Liu, Yingsheng Xu, Dongsheng Fan   +4 more
doaj   +1 more source

Difficulties in diagnosing amyotrophic lateral sclerosis in a HIV-Positive Patient

Журнал инфектологии, 2018
We described a case of amyotrophic lateral sclerosis (ALS) with comorbid HIV infection. The diagnosis was confirmed by genetic tests. The difficulty of the differential diagnosis between amyotrophic lateral sclerosis and HIV-associated ALS syndrome is ...
T. M. Alekseeva, N. V. Skripchenko, S. V. Lobzin, V. S. Demeshonok, E. A. Yurkina, V. D. Nazarov, S. V. Lapin   +6 more
doaj   +1 more source

Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosis

Brain Communications, 2020
Objective biomarkers for the clinically heterogeneous adult-onset neurodegenerative disorder amyotrophic lateral sclerosis are crucial to facilitate assessing emerging therapeutics and improve the diagnostic pathway in what is a clinically heterogeneous ...
Greig Joilin, E. Gray, A. Thompson, Y. Bobeva, K. Talbot, Jochen H Weishaupt, A. Ludolph, A. Malaspina, P. Leigh, S. Newbury, M. Turner, M. Hafezparast   +11 more
semanticscholar   +1 more source

The ‘Omics’ of Amyotrophic Lateral Sclerosis

Trends in Molecular Medicine, 2016
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease that primarily affects motor neurons and is accompanied by sustained unregulated immune responses, but without clear indications of the ultimate causative mechanisms. The identification of a diverse array of ALS phenotypes, a series of recently discovered mutations, and the links ...
Francisco J. Quintana, María L. García-Martín, Miguel G. Toscano, Soledad Lopez, Soledad Lopez, Jaime M. Franco, Jaime M. Franco, Diana Caballero-Hernández, Marta Cejudo-Guillén, Marta Cejudo-Guillén, David Pozo, David Pozo, Cintia Roodveldt   +12 more
openaire   +4 more sources

Dietary BMAA exposure in an amyotrophic lateral sclerosis cluster from southern France.

PLoS ONE, 2013
BackgroundDietary exposure to the cyanotoxin BMAA is suspected to be the cause of amyotrophic lateral sclerosis in the Western Pacific Islands. In Europe and North America, this toxin has been identified in the marine environment of amyotrophic lateral ...
Estelle Masseret, Sandra Banack, Farid Boumédiène, Eric Abadie, Luc Brient, Fabrice Pernet, Raoul Juntas-Morales, Nicolas Pageot, James Metcalf, Paul Cox, William Camu, French Network on ALS Clusters Detection and Investigation   +11 more
doaj   +1 more source