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Personalized Precision Immunotherapy for Amyotrophic Lateral Sclerosis (ALS)
Critical Reviews in Immunology, 2023Neurological syndrome amyotrophic lateral sclerosis (ALS) affects motor neurons and is characterized by progressive motor neuron loss in the brain and spinal cord. ALS starts with mainly focal onset but when the disease progresses, it spreads to different parts of the body, with survival limits of 2-5 years after disease initiation.
Dipnarine, Maharaj +3 more
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Emotional adjustment in amyotrophic lateral sclerosis (ALS)
Journal of Neurology, 2011Despite the devastating motor impairment, a significant number of patients with amyotrophic lateral sclerosis (ALS) maintain a good psychosocial adjustment. Here we investigated whether this is specific for ALS or a more general characteristic of terminal disease.
Lulé, Dorothée +7 more
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Psychiatric Aspects of Amyotrophic Lateral Sclerosis (ALS)
Current Psychiatry Reports, 2010Amyotrophic lateral sclerosis (ALS) is a progressive disorder characterized by degeneration of motor neurons. Given the severe nature of ALS, many believed that patients would suffer from a high level of depression and a low quality of life. However, research into the psychological health of patients with ALS has shown that this is not the case.
Lorenzo, Norris +2 more
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Amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD).
Archives italiennes de biologie, 2011There is increasing clinical, imaging and neurophatological evidence that amyotrophic lateral sclerosis (ALS) represents a multisystem neurodegenerative disease. Neurodegeneration is not restricted to motor neurons, but also includes parts of the brain other than the motor cortex, especially the prefrontal and/or anterior temporal lobe, that contribute
S. Zago +4 more
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Molecular Abnormalities in Sporadic Amyotrophic Lateral Sclerosis (ALS)
The FASEB Journal, 2007ALS is a neurodegenerative disease affecting both upper and lower motor neurons. A mutation in the superoxide dismutase I (SOD1) gene has been implicated in the familial form of disease; however, little is known about the pathogenesis of sporadic ALS, which accounts for 90–95% of the cases.
Hannah Perrin +4 more
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Coffee and amyotrophic lateral sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by progressive loss of motor neurons. The effective treatments for ALS remain elusive, necessitating exploration into novel preventive strategies. ALS pathogenesis is triggered by oxidative stress which results in neuroinflammation, exicitotoxicity and ...Adejoke Elizabeth, Memudu +3 more
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Immunological Assessment in Sporadic Amyotrophic Lateral Sclerosis (ALS)
1987The immune system may be able to contribute to the pathogenesis of ALS as it has to other neurological diseases such as experimental allergic encephalomyelitis, multiple sclerosis and lymphocytic choriomeningitis. The selective damage to upper and lower motor neurons in ALS might be regarded as a feature of a brain-confined, organ-specific autoimmune ...
L, Provinciali +4 more
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Psychodynamic Aspects in Patients with Amyotrophic Lateral Sclerosis (ALS)
1987The paper by Rabin et al.[l] of the Vanderbilt School of Medicine (Nashville) in which he relates his own experience as an ALS patient is more effective than any review of the literature in understanding the psychological impact of this disease. Before introducing our psychodynamic approach to the psychological problems of this ‘incurable’ illness, we ...
Ferro, Fm +3 more
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